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| Status |
Public on Dec 17, 2013 |
| Title |
Transformation of the Fallopian Tube Secretory Epithelium Leads to High-grade Serous Ovarian Cancer in BRCA/P53/PTEN Models |
| Organism |
Mus musculus |
| Experiment type |
Genome variation profiling by genome tiling array
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| Summary |
Our study presents the first genetic models of de novo high-grade serous carcinomas (HGSC) that originate in fallopian tube secretory epithelial cells and recapitulate the key genetic alterations and precursor lesions characteristic of human invasive ovarian cancer. Genomic copy number analysis, using array CGH, was performed on murine tumors in order to compare the overlap of copy number alterations between HGSC models and TCGA data.
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| Overall design |
Array CGH was performed on genomic DNA isolated from murine HGSC tumors. Genomic DNA from three normal mouse fallopian tubes was pooled and used as the reference.
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| Contributor(s) |
Setlur SR, Dinulescu D, Drapkin R |
| Citation(s) |
24332043 |
| |
| Submission date |
Aug 13, 2013 |
| Last update date |
Dec 19, 2013 |
| Contact name |
Sunita R Setlur |
| E-mail(s) |
ssetlur@partners.org
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| Organization name |
Brigham and Women's Hospital
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| Street address |
221 Longwood Avenue
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| City |
Boston |
| ZIP/Postal code |
02115 |
| Country |
USA |
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| Platforms (1) |
| GPL10448 |
Agilent-027414 SurePrint G3 Mouse CGH Microarray 1x1M |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA215028 |
