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| Status |
Public on Sep 10, 2013 |
| Title |
Limited effects of an eIF2αS51A allele on neurological impairments in the 5xFAD mouse model of Alzheimer’s disease |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Transcriptome analysis of hippocampal RNA samples from wild-type, 5xFAD, 5xFAD;eIF2α+/S51A and eIF2α+/S51A mice
Our transcriptome analyses showed clear transcriptional alterations in hippocampi of 5xFAD compared to wild type mice that were not corrected by the eIF2αS51A allele.
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| Overall design |
Hemizygous 5xFAD mice, which were on a genetic background of B6/SJL, were crossed with eIF2α+/S51A mice (C57BL/6J background), to generate the offspring that was analyzed in the microarray.
Hippocampal samples of 12 mice (4 groups: wild-type, 5xFAD, 5xFAD;eIF2α+/S51A and eIF2α+/S51A) were processed using Affymetrix Mouse Exon 1.0 ST platform. Array data was processed by Affymetrix Exon Array Computational Tool. No technical replicates were performed.
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| Contributor(s) |
Paesler K, Hettich MM, Siwek ME, Ryan DP, Schröder S, Papazoglou A, Broich K, Müller R, Becker A, Garthe A, Kempermann G, Weiergräber M, Ehninger D |
| Citation(s) |
25883808 |
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| Submission date |
Sep 02, 2013 |
| Last update date |
Mar 03, 2017 |
| Contact name |
Dan Ehninger |
| Organization name |
German Center for Neurodegenerative Diseases (DZNE)
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| Street address |
Ludwig-Erhard-Allee 2
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| City |
Bonn |
| State/province |
NRW |
| ZIP/Postal code |
53175 |
| Country |
Germany |
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| Platforms (1) |
| GPL6193 |
[MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [probe set (exon) version] |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA217853 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE50521_RAW.tar |
417.0 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
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