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| Status |
Public on Nov 04, 2013 |
| Title |
Afghan Hindu Kush: where Eurasian sub-continent gene flows converge |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
SNP genotyping by SNP array
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| Summary |
Despite being located at the crossroads of Asia, genetics of the Afghanistan populations have been largely overlooked. It is currently inhabited by five major ethnic populations: Pashtun, Tajik, Hazara, Uzbek and Turkmen. Here we present autosomal from a subset of our samples, mitochondrial and Y- chromosome data from over 500 Afghan samples among these 5 ethnic groups. This Afghan data was supplemented with the same Y-chromosome analyses of samples from Iran, Kyrgyzstan, Mongolia and updated Pakistani samples (HGDP-CEPH). The data presented here was integrated into existing knowledge of pan-Eurasian genetic diversity. The pattern of genetic variation, revealed by structure-like and Principal Component analyses and Analysis of Molecular Variance indicates that the people of Afghanistan are made up of a mosaic of components representing various geographic regions of Eurasian ancestry. The absence of a major Central Asian-specific component indicates that the Hindu Kush, like the gene pool of Central Asian populations in general, is a confluence of gene flows rather than a source of distinctly autochthonous populations that have arisen in situ: a conclusion that is reinforced by the phylogeography of both haploid loci.
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| Overall design |
24 samples were analysed with the Illumina platform Human660W-Quad v1.0 Genotyping BeadChip and are described herein.
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| Contributor(s) |
Villems R, Metspalu M |
| Citation(s) |
24204668 |
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| Submission date |
Sep 25, 2013 |
| Last update date |
Nov 12, 2013 |
| Contact name |
Mait Metspalu |
| E-mail(s) |
mait@ebc.ee
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| Phone |
+37283315
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| Organization name |
Estonian Biocentre
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| Street address |
Riia 23
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| City |
Tartu |
| ZIP/Postal code |
51010 |
| Country |
Estonia |
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| Platforms (1) |
| GPL8888 |
Illumina Human660W-Quad v1.0 BeadChip |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA221367 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE51158_Afghans_Matrix_processed.txt.gz |
281.0 Mb |
(ftp)(http) |
TXT |
| GSE51158_Afghans_Matrix_signal_intensities.txt.gz |
206.6 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
| Processed data are available on Series record |
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