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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jan 01, 2014 |
| Title |
Expression data in splenic DC subsets in wild type and Xbp1 deficient mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Xbp1 is a major transcription factor in the unfolded protein response. To uncover its function in DCs we generated a conditional KO for Xbp1 in dendritic cells. We here compare the expression of mRNAs in two different splenic DC subpopulations, CD8a and CD11b DCs in both WT and KO mice.
Reference: Inositol-requiring enzyme 1-alpha regulates CD8a dendritic cell function via regulated mRNA decay. Osorio et al, Nature Immunology (2014)
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| Overall design |
Primary DC subsets were isolated and sorted from spleens from 3 different WT or CD11c-cre Xbp-1fl/fl mice. RNA was isolated, converted to cDNA and then hybridised on Affymetrix GeneChip Mouse Gene 1.0 ST Arrays (GPL6246).
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| Contributor(s) |
Osorio F, Tavernier S, Hoffman E, Saeys Y, Martens L, Vetters J, Delrue I, De Rycke R, Parthoens E, Poulliot P, Iwawaki T, Janssens S, Lambrecht BN |
| Citation(s) |
24441789 |
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| Submission date |
Dec 02, 2013 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Sophie Janssens |
| E-mail(s) |
sophie.janssens@irc.vib-ugent.be
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| Organization name |
University of Ghent-VIB
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| Department |
VIB Inflammation Research Center
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| Street address |
Technologiepark 927
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| City |
Ghent |
| ZIP/Postal code |
9000 |
| Country |
Belgium |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (12)
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| GSM1277090 |
CD8 DC wild type, biological replicate 1 |
| GSM1277091 |
CD8 DC wild type, biological replicate 2 |
| GSM1277092 |
CD8 DC wild type, biological replicate 3 |
| GSM1277093 |
CD8 DC Xbp1 KO (DC conditional KO), biological replicate 1 |
| GSM1277094 |
CD8 DC Xbp1 KO (DC conditional KO), biological replicate 2 |
| GSM1277095 |
CD8 DC Xbp1 KO (DC conditional KO), biological replicate 3 |
| GSM1277096 |
CD11b DC wild type, biological replicate 1 |
| GSM1277097 |
CD11b DC wild type, biological replicate 2 |
| GSM1277098 |
CD11b DC wild type, biological replicate 3 |
| GSM1277099 |
CD11b DC Xbp1 KO (DC conditional KO), biological replicate 1 |
| GSM1277100 |
CD11b DC Xbp1 KO (DC conditional KO), biological replicate 2 |
| GSM1277101 |
CD11b DC Xbp1 KO (DC conditional KO), biological replicate 3 |
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| Relations |
| BioProject |
PRJNA230370 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE52857_RAW.tar |
53.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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