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| Status |
Public on Dec 13, 2013 |
| Title |
Human osteosarcoma cells respond to sorafenib chemotherapy by downregulation of the tumor progression factors S100A4, CXCR4 and the oncogene FOS |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Osteosarcoma is a rare but aggressive bone neoplasm in humans, which is commonly treated with surgery, classical chemotherapy and radiation. Here, we studied the antimetastatic potential of 4 μM of the multikinase inhibitor Sorafenib in a human osteosarcoma cell line using DNA microarray-based gene expression profiling.
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| Overall design |
3 untreated replicates of human osteosarcoma cells (ATCC CRL-1543™), 3 replicates of human osteosarcoma cells (ATCC CRL-1543™) treated with 4 µM Sorafenib
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| Contributor(s) |
Walter I, Wolfesberger B, Gallé B, Steinborn R |
| Citation(s) |
24378831 |
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| Submission date |
Dec 10, 2013 |
| Last update date |
Jan 27, 2016 |
| Contact name |
Birgit Gallé |
| Organization name |
ZMF
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| Street address |
Stiftingtalstr. 24
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| City |
Graz |
| ZIP/Postal code |
8010 |
| Country |
Austria |
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| Platforms (1) |
| GPL2986 |
ABI Human Genome Survey Microarray Version 2 |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA231022 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE53155_RAW.tar |
11.8 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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