|
| Status |
Public on Jun 16, 2015 |
| Title |
Targeting PBK/TOPK decreases growth and survival of glioblastoma stem cells in vitro and attenuates tumor growth in vivo |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Gene knockdown of PBK led to decreased proliferation and sphere formation in the GSC cultures. Treatment of cells with different concentrations of HI-TOPK-032 almost completely abolished growth and proliferation and elicited a large increase in apoptosis
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| |
|
| Overall design |
Total RNA isolated from GSC cultures featuring PBK gene knock-down (shRNA) was compared to that from non-silencing control GSC cultures (NS-shRNA). Total RNA isolated from GSC cultures treated with PBK-inhibitor was compared to that from untreated GSC cultures.
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| |
|
| Contributor(s) |
Stangeland B |
| Citation(s) |
26081429 |
| |
| Submission date |
Jan 03, 2014 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Biljana Stangeland |
| E-mail(s) |
biljana.stangeland@gmail.com
|
| Organization name |
Oslo University Hospital
|
| Department |
Institute of Surgical Research
|
| Lab |
VML
|
| Street address |
Sognsvannsveien 20
|
| City |
Oslo |
| ZIP/Postal code |
0027 |
| Country |
Norway |
| |
|
| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (36)
|
|
| Relations |
| BioProject |
PRJNA233313 |
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