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| Status |
Public on Aug 12, 2014 |
| Title |
Indole-3-Carbinol Preferentially Target ERĪ±-Positive Breast Cancer Cells. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Indole-3-carbinol (I3C) is a natural anti-carcinogenic compound found at high concentrations in Brassica vegetables. ER-positive cell lines demonstrated the greatest sensitivity to the anti-tumor effects of I3C compared to ER-negative breast cancer cell lines. Gene expression analysis was performed to identify genes and pathways that accounted for sensitivity to I3C.
Microarray analysis performed using Illumina HT-12 v4 expression arrays
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| Overall design |
A total of 36 samples were analyzed with six breast cancer cell lines treated with either the vehicle control or the drug Indole-3-carbinol in triplicate. The cell lines were: MCF-7, T47D, ZR751(sensitive to the drug, apoptosis/growth arrest) and MDA-MB-231, MDA-MB-157, and MDA-MB-436 (insensitive to the drug). Sensitive cell lines are of the luminal subtype and insensitive cell lines are of the basal subtype.
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| Contributor(s) |
Caruso JA, Keyomarsi K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Mar 13, 2014 |
| Last update date |
Jan 28, 2016 |
| Contact name |
Khandan Keyomarsi |
| E-mail(s) |
kkeyomar@mdanderson.org
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| Phone |
713-792-4845
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| Organization name |
MD Anderson Cancer Center
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| Department |
Experimental Radiation Oncology
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| Street address |
1515 Holcombe Blvd. Unit 66
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| City |
Houston |
| State/province |
Tx |
| ZIP/Postal code |
77030 |
| Country |
USA |
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| Platforms (1) |
| GPL10904 |
Illumina HumanHT-12 V4.0 expression beadchip (gene symbol) |
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| Samples (36)
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| Relations |
| BioProject |
PRJNA241265 |
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