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| Status |
Public on Mar 26, 2017 |
| Title |
Transposable element targeting by piRNAs in Laurasiatherians with distinct TE activities |
| Organisms |
Canis lupus familiaris; Equus caballus; Eptesicus fuscus |
| Experiment type |
Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
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| Summary |
Transposable elements (TEs) are self-mobilizing elements that make up a large fraction of mammalian genomes. PIWI proteins and PIWI interacting RNAs (piRNAs) are a part of a system aimed at controlling and preventing TE proliferation. We examined the TE landscape and piRNA repertoires from three non-model Laurasiatherian mammals (dog, horse and big brown bat) with differing TE complements and proliferation patterns to address questions about the evolutionary relationships between piRNAs and TEs. We found that the genomic abundance of new TEs may not match TE transcription. We speculate that a higher rate of SINE targeting by piRNAs in the horse genome contributed to the reduced SINE insertion rate.
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| Overall design |
Two testicular tissue sample from three taxa. Six samples total
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| Contributor(s) |
Vandewege MW, Platt RN, Ray DA, Hoffmann FG |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Mar 28, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Michael W Vandewege |
| E-mail(s) |
mike.vandewege@gmail.com
|
| Organization name |
Mississippi State University
|
| Street address |
32 Creelman St
|
| City |
Mississippi State |
| State/province |
Mississippi |
| ZIP/Postal code |
39762 |
| Country |
USA |
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| Platforms (3) |
| GPL15545 |
Illumina HiSeq 2000 (Equus caballus) |
| GPL16540 |
Illumina HiSeq 2000 (Canis lupus familiaris) |
| GPL17229 |
Illumina HiSeq 2000 (Eptesicus fuscus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA242941 |
| SRA |
SRP040683 |
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