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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Aug 15, 2014 |
| Title |
Expression data from salivary tumor tissues derived from MMTV-ras transgenic mice with wild-type p53, no p53 or gain-of-function mutant p53 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Salivary tumors isolated from MMTV-ras transgenic mice expressing wild-type p53, no p53 or p53R172H gain-of-funcion mutant were subjected to genome-wide gene expression profiling to assess the effect of the different p53 status on tumor gene expression.
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| Overall design |
A total of 12 spontaneous salivary tumors from MMTV-ras/p53+/+, MMTV-ras/p53-/- or MMTV-ras/p53R172H/R172H mice (4 tumors per genotype) were analyzed using Affymetric GeneChip for gene expression profiling. The multi-class comparison function of Significance Analysis of Microarray (SAM) with an FDR of 1% was used to identify genes that are differentially regulated across the three genotypic groups.
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| Contributor(s) |
i Jiang D, Windle JJ |
| Citation(s) |
25695772 |
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| Submission date |
Jul 16, 2014 |
| Last update date |
May 04, 2018 |
| Contact name |
Dadi Jiang |
| Organization name |
Stanford University
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| Street address |
269 Campus Drive, CCSR-South 1240
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| City |
Stanford |
| State/province |
CA |
| ZIP/Postal code |
94305 |
| Country |
USA |
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| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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| Samples (12)
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| GSM1437217 |
Salivary tumor from MMTV-ras/p53+/+ mouse, rep 1 |
| GSM1437218 |
Salivary tumor from MMTV-ras/p53+/+ mouse, rep 2 |
| GSM1437219 |
Salivary tumor from MMTV-ras/p53+/+ mouse, rep 3 |
| GSM1437220 |
Salivary tumor from MMTV-ras/p53+/+ mouse, rep 4 |
| GSM1437221 |
Salivary tumor from MMTV-ras/p53-/- mouse, rep 1 |
| GSM1437222 |
Salivary tumor from MMTV-ras/p53-/- mouse, rep 2 |
| GSM1437223 |
Salivary tumor from MMTV-ras/p53-/- mouse, rep 3 |
| GSM1437224 |
Salivary tumor from MMTV-ras/p53-/- mouse, rep 4 |
| GSM1437225 |
Salivary tumor from MMTV-ras/p53R172H/R172H mouse, rep 1 |
| GSM1437226 |
Salivary tumor from MMTV-ras/p53R172H/R172H mouse, rep 2 |
| GSM1437227 |
Salivary tumor from MMTV-ras/p53R172H/R172H mouse, rep 3 |
| GSM1437228 |
Salivary tumor from MMTV-ras/p53R172H/R172H mouse, rep 4 |
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| Relations |
| BioProject |
PRJNA255359 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE59452_RAW.tar |
39.9 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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