|
| Status |
Public on Oct 01, 2015 |
| Title |
Genome-wide maps of PARP-1-bound nucleosomes (human) |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
PARP-1 binds to specific nucleosomes to regulate gene activity. While PARP-1's role in transcription inititaion is known, a surprising finding here was that PARP-1 is highly enriched at exon-intron and intron-exon boundaries, sort of demarcting exons. Thius indicating a role in alternative splicing.
|
| |
|
| Overall design |
ChIP-seq of PARP-1-bound nucleosomes
|
| |
|
| Contributor(s) |
Nalabothula N, Al-jumaily T, Xiaorong S, Eteleeb AM, Xiarong S, Flight RM, Moseley H, Rouchka EC, Fondufe-Mittendorf YN |
| Citation(s) |
26305327 |
| |
| Submission date |
Sep 30, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Yvonne Nsokika Fondufe-Mittendorf |
| E-mail(s) |
y.fondufe-mittendorf@uky.edu
|
| Phone |
8593230091
|
| Organization name |
University of Kentucky
|
| Department |
Biochemistry
|
| Lab |
Mittendorf
|
| Street address |
741 South Limestone dr.
|
| City |
Lexington |
| State/province |
KY |
| ZIP/Postal code |
40536-0509 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16558 |
AB 5500 Genetic Analyzer (Homo sapiens) |
|
| Samples (2) |
|
| Relations |
| BioProject |
PRJNA262735 |
| SRA |
SRP048559 |
