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| Status |
Public on Dec 31, 2016 |
| Title |
Gene expression profiling of transgenic d16HER2- and WT HER2-positive transgenic mammary tumor cell lines |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
d16HER2 is a splice variant of HER2 receptor characterized by a significant tumor aggressiveness. We derived primary tumor cell lines from spontaneous tumors grown in mice transgenic respectively for human d16 (MI6 and MI7 cell lines) and WT HER2 isoforms (WTHER2_1 and WTHER2_2). To analyze the molecular mechanisms underlying the higher tumorigenicity of d16HER2 than that of WTHER2, we conducted gene expression profiling analysis of these cell lines.
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| Overall design |
Gene expression profiling was performed using RNA from two transgenic d16HER2-positive (named MI6 and MI7) and two transgenic WT HER2-positive (named WTHER2_1 and WTHER2_2) mammary tumor cell lines.
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| Citation(s) |
27641338 |
| |
| Submission date |
Mar 26, 2015 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Loris De Cecco |
| E-mail(s) |
loris.dececco@istitutotumori.mi.it
|
| Organization name |
IRCSS Istituto Nazionale Tumori
|
| Street address |
via Venezian 1
|
| City |
Milan |
| ZIP/Postal code |
20133 |
| Country |
Italy |
| |
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| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA279460 |
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