 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Sep 09, 2015 |
| Title |
Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Here we present an RNAseq analysis of human bone samples, obtained from iliac crest needle biopsies, to yield the first in vivo interrogation of all genes and pathways that may be altered in bone with aging and E therapy in humans.
|
| |
|
| Overall design |
58 healthy women were studied, including 19 young women (mean age ± SD, 30.3 ± 5.4 years), 19 old women (73.1 ± 6.6 years), and 20 old women treated with 3 weeks of E therapy (70.5 ± 5.2 years). Using generally accepted criteria (false discovery rate [q] < 0.10), aging altered a total of 678 genes and 12 pathways, including a subset known to regulate bone metabolism (e.g., Notch).
|
| |
|
| Contributor(s) |
Khosla S, Monroe DG |
| Citation(s) |
26402159, 31911667 |
| |
| Submission date |
Sep 08, 2015 |
| Last update date |
Jun 13, 2022 |
| Contact name |
Sundeep Khosla |
| Organization name |
Mayo Clinic
|
| Department |
Endocrinology Research
|
| Street address |
200 1st St SW
|
| City |
Rochester |
| State/province |
MN |
| ZIP/Postal code |
55906 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (58)
|
|
| Relations |
| BioProject |
PRJNA295101 |
| SRA |
SRP063477 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE72815_YOE_counts.csv.gz |
2.4 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...