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| Status |
Public on Nov 01, 2016 |
| Title |
Gene expression profiling of tamoxifen-resistant breast cancer MCF7L cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Endocrine resistance is a major obstacle in treating estrogen receptor α (ER)-positive (+) breast cancer. In order to better understand the mechanism of endocrine resistance, we established a stable tamoxifen-resistant (TamR) MCF7L cell model by culturing the parental (P) MCF7L cells in the presence of 100 nM of 4-hydroxytamoxifen (4HT) for over 6 months. To characterize the transcriptomic profiles in these cells, we performed an RNA-seq analysis.
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| Overall design |
Gene expression profiles (by RNA-seq) were taken of a TamR cell model. The tamoxifen-sensitive P cells and TamR cells were compared to each other.
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| Contributor(s) |
Fu X, Griffith OL, Schiff R |
| Citation(s) |
27791031 |
| |
| Submission date |
Nov 24, 2015 |
| Last update date |
Mar 05, 2024 |
| Contact name |
Xiaoyong Fu |
| E-mail(s) |
xiaoyonf@bcm.edu
|
| Phone |
713-798-1626
|
| Organization name |
Baylor College of Medicine
|
| Department |
Breast Center
|
| Street address |
1 Baylor Plaza
|
| City |
Houston |
| State/province |
Tx |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL9052 |
Illumina Genome Analyzer (Homo sapiens) |
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| Samples (2) |
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| This SubSeries is part of SuperSeries: |
| GSE75372 |
FOXA1 overexpression mediates endocrine resistance by increasing IL-8 in oestrogen receptor-positive breast cancer |
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| Relations |
| BioProject |
PRJNA304011 |
| SRA |
SRP066626 |
