|
| Status |
Public on Jun 08, 2016 |
| Title |
Systems level analyses establish CodY as a multifaceted metabolic regulator integrating metabolism, motility and virulence in Listeria monocytogenes |
| Organism |
Listeria monocytogenes 10403S |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To gain knowledge on L. monocytogenes differential CodY activity, we set on analyzing CodY’s regulon in L. monocytogenes in both rich and minimal growth conditions using genome-wide sequencing techniques. Remarkably, we identified for the first time a global regulatory role for CodY when BCAAs are limited, that are similar to those within the mammalian niche. Furthermore, our data establish CodY as a central regulator that integrates metabolism, motility, stress responses and virulence in L. monocytogenes.
|
| |
|
| Overall design |
Examination of CodY regulon in rich and minimal conditions.
Sample codY_LBMM_3 did not correlate with the other two replicates and was therefore omitted.
|
| Web link |
http://www.ncbi.nlm.nih.gov/pubmed/26895237
|
| |
|
| Contributor(s) |
Lobel L, Herskovits AA |
| Citation(s) |
26895237 |
| |
| Submission date |
Dec 18, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Lior Lobel |
| E-mail(s) |
liorlabe@post.tau.ac.il
|
| Organization name |
Tel Aviv University
|
| Department |
Molecular Microbiology
|
| Lab |
Anat Herskovits
|
| Street address |
Ramat Aviv
|
| City |
Tel Aviv |
| State/province |
Israel |
| ZIP/Postal code |
69978 |
| Country |
Israel |
| |
|
| Platforms (1) |
| GPL20912 |
Illumina HiSeq 2500 (Listeria monocytogenes 10403S) |
|
| Samples (11)
|
|
| Relations |
| BioProject |
PRJNA306500 |
| SRA |
SRP067580 |
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