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| Status |
Public on Feb 07, 2017 |
| Title |
Effect of SF3B1 suppression in cancer cells with different SF3B1 copy-number levels |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Breast cancer cell lines containing stable dox inducible shRNAs targeting SF3B1 were profiled by RNA sequencing. We determined the effect of gene expression and splicing changes before and after knocking down SF3B1 in cell lines with normal copy number (SF3B1neutral) or partial copy loss (SF3B1loss) cell lines
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| Overall design |
RNA profiles for SF3B1 suppression were generated from 8 breast cancer cell line pairs (-/+ dox) with no techincal replicates.
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| Contributor(s) |
Paolella BR, Gibson WJ |
| Citation(s) |
28177281 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| F30 CA192725 |
Hemizygous deletion of esential genes enables a novel therqpeutic vulnerability in cancer |
HARVARD UNIVERSITY (MEDICAL SCHOOL) |
Gibson |
| F32 CA180653 |
Cancer Specific Sensitivity to Suppression of Spliceosome Components |
DANA-FARBER CANCER INSTITUTE |
Paolella |
| L40 CA179861 |
Cancer-Specific Vulnerability to Suppression of Spliceosome Components: Neuroblastoma Specific Sensitivity to Spliceosome Inhibition |
LOAN REPAYMENT APPLICATIONS |
Paolella |
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| |
| Submission date |
May 27, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Brenton Paolella |
| Organization name |
Dana-Farber Cancer Institute
|
| Lab |
Rameen Beroukhim
|
| Street address |
450 Brookline Ave. Smith 1010
|
| City |
Boston |
| State/province |
Massachusetts |
| ZIP/Postal code |
02215 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (16)
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| Relations |
| BioProject |
PRJNA323711 |
| SRA |
SRP075880 |
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