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| Status |
Public on Oct 05, 2007 |
| Title |
Comparison of human epididymal gene expression in the caput epididymides of infertile and fertile patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Caput epididymides biopsies from 4 patients suffering from non-obstructive azoospermia and from 4 patients with active spermatogenesis were compared. 414 genes in the caput epididymides were differentially regulated in infertile men by at least a 2-fold change as compared to the fertile men.
Keywords: Comparison of infertile and fertile caput epididymides
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| Overall design |
Comparative caput epididymal gene expression from 4 patients with either active spermatogenesis (reference samples) or non-obstructive azoospermia. On each array, infertile tissue were compared to fertile tissue. Whenever the fertile tissues were labeled with cyanine 5 (see samples entitled "Patients 1 and 2" and "Patients 7 and 8"), the fluorescence ratios were swapped. Data was normalized using a locally weighted regression Lowess method and genes were considered differentially expressed in infertile sample versus fertile sample if there was at least a 2-fold change in 3 patients out of 4.
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| Contributor(s) |
Dubé E, Hermo L, Chan P, Cyr DG |
| Citation(s) |
17928628 |
| |
| Submission date |
Sep 28, 2007 |
| Last update date |
Dec 06, 2012 |
| Contact name |
Daniel Cyr |
| E-mail(s) |
daniel.cyr@iaf.inrs.ca
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| Phone |
514-630-8833
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| Fax |
514-630-8850
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| Organization name |
INRS-Institut Armand-Frappier
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| Street address |
245, Boulevard Hymus
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| City |
Pointe-Claire |
| State/province |
Québec |
| ZIP/Postal code |
H9R1G6 |
| Country |
Canada |
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| Platforms (1) |
| GPL887 |
Agilent-012097 Human 1A Microarray (V2) G4110B (Feature Number version) |
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| Samples (5)
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| Relations |
| BioProject |
PRJNA102767 |
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