|
| Status |
Public on Oct 12, 2007 |
| Title |
Expression profiles of mouse medulloblastoma |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Dysregulatio of Hh signaling has been shown to be involved in the formation of human medulloblastoma. We generated a mouse model (CAGGS-CreER;R26-SmoM2) of Hh related tumors.
We used microarray to profile gene expression in Hh induced mouse medulloblastoma and identified distinct classes of up-regulated or down-regulated genes during Hh dependent tumorigenesis .
Keywords: Tumor vs wild type tissue
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| |
|
| Overall design |
Medulloblastoma samples and adjacent wild type cerebellar tissue from CAGGS-CreER;R26-SmoM2 mice were isolated for RNA extraction and hybridization on Affymetrix microarrays.
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| |
|
| Contributor(s) |
Mao J, Ligon K, Rowitch D, McMahon A |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Oct 11, 2007 |
| Last update date |
Jan 08, 2019 |
| Contact name |
Junhao Mao |
| E-mail(s) |
jmao@mcb.harvard.edu
|
| Organization name |
Harvard University
|
| Department |
MCB
|
| Street address |
16 Divinity Ave., BL 1048
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02138 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL339 |
[MOE430A] Affymetrix Mouse Expression 430A Array |
| GPL340 |
[MOE430B] Affymetrix Mouse Expression 430B Array |
|
| Samples (10)
|
| GSM236989 |
Wild type cerebellum, biological rep1 (430A) |
| GSM236990 |
Wild type cerebellum, biological rep2 (430A) |
| GSM236991 |
Medulloblastoma, biological rep1 (430A) |
| GSM236992 |
Medulloblastoma, biological rep2 (430A) |
| GSM236993 |
Medulloblastoma, biological rep3 (430A) |
| GSM236994 |
Wild type cerebellum, biological rep1 (430B) |
| GSM236995 |
Wild type cerebellum, biological rep2 (430B) |
| GSM236996 |
Medulloblastoma, biological rep1 (430B) |
| GSM236997 |
Medulloblastoma, biological rep2 (430B) |
| GSM236998 |
Medulloblastoma, biological rep3 (430B) |
|
| Relations |
| BioProject |
PRJNA102945 |
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