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| Status |
Public on Aug 01, 2017 |
| Title |
Identification of Candida albicans traits that sustain its commensal dwelling in the mammalian gut |
| Organism |
Candida albicans |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Goal: We employed RNA-seq to identify targets of regulation of five Candida albicans transcription regulators (Try4, Zfu2 and Zcf8). These regulators were identifyed through a genetic screen in a gnotobiotic mouse model of Candida albicans gut colonization.
Results: We found that the five regulators comprise a complex transcriptional network (>500 targets of regulation) that partitions in two sub-networks. One sub-network is formed by Rtg1 and Rtg3. The other comprises the regulators Try4, Zfu2 and Zcf8.
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| Overall design |
Comparison of the transcriptome of Candida albicans wild-type reference strain vs. five transcription regulator deletion mutants. One growth condition, two biological replicates per sample. RNA-seq data generated with Illumina HiSeq2500.
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| Contributor(s) |
Perez JC, Ludwig T |
| Citation(s) |
29069103 |
| |
| Submission date |
Mar 13, 2017 |
| Last update date |
Jun 19, 2019 |
| Contact name |
Tobias Ludwig |
| E-mail(s) |
tobias.ludwig@uni-wuerzburg.de
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| Organization name |
Institute for Molecular Infection Biology
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| Lab |
AG Perez
|
| Street address |
Josef-Schneider-Straße 2
|
| City |
Würzburg |
| ZIP/Postal code |
97080 |
| Country |
Germany |
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| Platforms (1) |
| GPL19036 |
Illumina HiSeq 2500 (Candida albicans) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA378991 |
| SRA |
SRP101796 |
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