Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing
Summary
We report ChIP-seq, RNA-seq, and ATAC-seq results from HEK293T cells transfected with various versions of the meiotic recombination protein PRDM9, in order to learn about its DNA-binding properties, its effects on gene expression and chromatin organization, and which epigenetic factors influence binding and recombination outcomes.
Overall design
ChIP-seq data on tagged transfected PRDM9 alleles in HEK293T cells, plus H3K4me3 and H3K36me3 ChIP-seq data and RNA-seq and ATAC-seq data from transfected and untransfected HEK293T cells.
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