FAS Fas cell surface death receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: FASprovided by HGNC
Official Full Name: Fas cell surface death receptorprovided by HGNC
Primary source: HGNC:HGNC:11920
See related: Ensembl:ENSG00000026103 MIM:134637; AllianceGenome:HGNC:11920
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
Annotation information: Note: FAS (Gene ID: 355) and FASN (Gene ID: 2194) share the FAS symbol/alias in common. FAS is a widely used alternative name for fatty acid synthase (FASN), which can be confused with the official symbol for FAS (Fas cell surface death receptor, GeneID 355). [01 Jun 2018]
Expression: Ubiquitous expression in colon (RPKM 4.3), lymph node (RPKM 4.0) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q23.31

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (88964050..89017059)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (89847964..89900944)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (90750555..90776816)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Advanced multiparametric image spectroscopy and super-resolution microscopy reveal a minimal model of CD95 signal initiation.
Title: Advanced multiparametric image spectroscopy and super-resolution microscopy reveal a minimal model of CD95 signal initiation.
[Porphyromonas gingivalis infection facilitates immune escape of esophageal cancer by enhancing YTHDF2-mediated Fas degradation].
Title: [Porphyromonas gingivalis infection facilitates immune escape of esophageal cancer by enhancing YTHDF2-mediated Fas degradation].
Somatic mutations in FAS pathway increase hemophagocytic lymphohistiocytosis risk in patients with T- and/or NK-cell lymphoma.
Title: Somatic mutations in FAS pathway increase hemophagocytic lymphohistiocytosis risk in patients with T- and/or NK-cell lymphoma.
CD95L concatemers highlight different stoichiometries of CD95-mediated apoptotic and nonapoptotic pathways.
Title: CD95L concatemers highlight different stoichiometries of CD95-mediated apoptotic and nonapoptotic pathways.
CD95 promotes stemness of colorectal cancer cells by lncRNA MALAT1.
Title: CD95 promotes stemness of colorectal cancer cells by lncRNA MALAT1.
Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells.
Title: Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells.
Interactions of genetic variations in FAS, GJB2 and PTPRN2 are associated with noise-induced hearing loss: a case-control study in China.
Title: Interactions of genetic variations in FAS, GJB2 and PTPRN2 are associated with noise-induced hearing loss: a case-control study in China.
Abnormal biomarkers predict complex FAS or FADD defects missed by exome sequencing.
Title: Abnormal biomarkers predict complex FAS or FADD defects missed by exome sequencing.
Glycemic Index, Glycemic Load, and FAS rs6586161 Polymorphism in Relation to Gastric Cancer Risk: A Case-Control Study in Korea.
Title: Glycemic Index, Glycemic Load, and FAS rs6586161 Polymorphism in Relation to Gastric Cancer Risk: A Case-Control Study in Korea.
Blood soluble Fas concentrations and ischemic stroke patient mortality.
Title: Blood soluble Fas concentrations and ischemic stroke patient mortality.

Submit: New GeneRIF Correction See all GeneRIFs (962)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Autoimmune lymphoproliferative syndrome type 1 MedGen: C1328840 OMIM: 601859 GeneReviews: Autoimmune Lymphoproliferative Syndrome	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2022-02-08) ClinGen Genome Curation Page Haploinsufficency Little evidence for dosage pathogenicity (Last evaluated 2022-02-08) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 binds and signals through CD4, which leads to T cell activation with upregulation of the CXCR5, PD-1, Fas, and FasL expression	PubMed
	env	CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway	PubMed
	env	Binding of HIV-1 gp120 to CD4 downregulates Bcl-2 protein in CD4+ T lymphocytes and facilitates Fas/Fas-ligand triggered apoptosis; addition of IL-2 rescues CD4+ T cells from CD4/gp120-induced Bcl-2 down modulation and apoptosis induction	PubMed
	env	Apoptosis induced by HIV-1 gp120/CD4 cross-linking in Th1 clones is inhibited by anti-CD95 or anti-CD95L neutralizing monoclonal antibodies, as well as by a specific interleukin-1 beta converting enzyme (ICE) inhibitor	PubMed
	env	HIV-1 gp120-induced neuron apoptosis requires the upregulation of the death receptor Fas and its associated death proteins, FADD and CASP8	PubMed
	env	At high concentrations, HIV-1 gp120 enhances expression of Fas and FasL and promotes apoptosis in human mesangial cells (HMC)	PubMed
	env	HIV-1 gp120-mediated CD4 engagement is involved in the induction of susceptibility of primary human T lymphocytes to CD95-mediated apoptosis through ezrin phosphorylation and ezrin-to-CD95 association	PubMed
	env	HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules	PubMed
	env	CXCR4-tropic and CXCR4/CCR5 dual-tropic HIV-1 gp120 induce the relocalization of cytoplasmic CD95 to the cellular plasma membrane and a 23% increase in CD95-mediated apoptosis	PubMed
	env	Preincubation of T cells with HIV-1 gp120 accelerates the apoptosis observed during CD2-pathway stimulation of the T cells; this process is mediated by Fas/Fas ligand interaction and related to an increased induction of Fas ligand mRNA by gp120	PubMed
	env	Antibodies reactive to a domain within the V3 region of HIV-1 gp120 are effective cross-linkers of Fas and increase apoptosis in peripheral T cells	PubMed
Envelope surface glycoprotein gp160, precursor	env	The calmodulin-binding domains in HIV-1 gp160 are involved in Fas-mediated apoptosis	PubMed
Nef	nef	HIV-1 Nef specifically incorporates CSF2, PPBP (NAP2), CCL5, TNF, FAS, CXCL1, IL12B, MIF and OSM into plasma extracellular vesicles from HIV-1 infected patient samples	PubMed
	nef	HIV-1 Nef sensitizes CD4+ T lymphoid cells to apoptosis by upregulating the expression of both Fas and Fas ligand, an effect that requires the PxxP motif (amino acids 72-75) in the core region of Nef	PubMed
	nef	Amino acid 106 of HIV-1 Nef is important for the inhibition of Fas-mediated apoptosis resulting from the interaction of Nef with ASK1	PubMed
	nef	HIV-1 Nef inhibits Fas-mediated apoptosis by binding to and inactivating the catalytic activity of ASK1, as well as through the downregulation of caspase-3 and caspase-8	PubMed
	nef	In a murine model of AIDS, CD4C/HIV transgenic (Tg) mice expressing HIV-1 Nef, it has been shown that Nef upregulates expression of Fas and FasL in CD4+ and CD8+ cells from the Tg mouse	PubMed
Tat	tat	HIV-1 Tat sensitizes T cells to CD95 mediated apoptosis through the upregulation of CD95 ligand and caspase 8	PubMed
	tat	HIV-1 Tat activates B and T cells and upregulates expression of Fas (CD95) in these cells	PubMed
Vpr	vpr	Virion-associated Vpr activates caspase 3/7, 8, and 9 in Fas-mediated apoptosis in Jurkat T cells and human activated PBMCs	PubMed
Vpu	vpu	Increased susceptibility of HIV-infected cells to Fas killing has been mapped to the HIV-1 vpu gene	PubMed
integrase	gag-pol	IL-7 and CD95 synergistically promote survival and proliferation of HIV-1-latently infected CD4+ T-cells measured by increased levels of integrated HIV-1 DNA, suggesting that HIV-1 IN interacts with IL-7 and CD95 in latently infected CD4+ T-cells	PubMed
matrix	gag	HIV-1 MA increases FAS mRNA expression in HepG2 cells and primary hepatocytes	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10S2281 (e-PCR)
- UniSTS:79142

TNFRSF6_1709 (e-PCR)
- UniSTS:277831

SHGC-30908 (e-PCR)
- UniSTS:57418

RH11007 (e-PCR)
- UniSTS:72023

GDB:362780 (e-PCR)
- UniSTS:156762

GDB:362783 (e-PCR)
- UniSTS:156763

GDB:362785 (e-PCR)
- UniSTS:156764

GDB:681362 (e-PCR)
- UniSTS:158618

G65659 (e-PCR)
- UniSTS:225450

GDB:682143 (e-PCR)
- UniSTS:158637

GDB:682147 (e-PCR)
- UniSTS:158638

RH91808 (e-PCR)
- UniSTS:89274

csnptnfrsf6-pcr2-1 (e-PCR)
- UniSTS:243158

csnptnfrsf6-pcr3-1 (e-PCR)
- UniSTS:243159

csnptnfrsf6-pcr4-1 (e-PCR)
- UniSTS:243160

csnptnfrsf6-pcr5-1 (e-PCR)
- UniSTS:243161

csnptnfrsf6-pcr6-1 (e-PCR)
- UniSTS:243162

csnptnfrsf6-pcr7-1 (e-PCR)
- UniSTS:243163

PMC96480P1 (e-PCR)
- UniSTS:273628

csnptnfrsf6-pcr8-1 (e-PCR)
- UniSTS:243164

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables tumor necrosis factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Fas signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in Fas signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation-induced cell death of T cells	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to amino acid starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hyperoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in motor neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in necroptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in necroptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of reactive oxygen species biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	TAS Traceable Author Statement more info	PubMed
involved_in regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of stress-activated MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CD95 death-inducing signaling complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CD95 death-inducing signaling complex	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
part_of death-inducing signaling complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	HDA more info	PubMed
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 6

Names: APO-1 cell surface antigen; CD95 antigen; FASLG receptor; Fas (TNF receptor superfamily, member 6); Fas AMA; TNF receptor superfamily member 6; apoptosis antigen 1; apoptosis signaling receptor FAS; apoptosis-mediating surface antigen FAS; mutant tumor necrosis receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009089.2 RefSeqGene

Range

5001..30255

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_134

mRNA and Protein(s)

NM_000043.6 → NP_000034.1 tumor necrosis factor receptor superfamily member 6 isoform 1 precursor

See identical proteins and their annotated locations for NP_000034.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK026195, AK290978, AL157394, BC012479, BU620333

Consensus CDS

CCDS7393.1

UniProtKB/Swiss-Prot

A9UJX4, B6VNV4, P25445, Q14292, Q14293, Q14294, Q14295, Q16652, Q5T9P1, Q5T9P2, Q5T9P3, Q6SSE9

UniProtKB/TrEMBL

A0A1B0QZF0, Q6ICT6

Related

ENSP00000498466.1, ENST00000652046.1

Conserved Domains (2) summary

cd08316
Location:226 → 319

Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6

cd10579
Location:39 → 167

TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)
NM_001320619.2 → NP_001307548.1 tumor necrosis factor receptor superfamily member 6 isoform 4 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks an alternate exon in the 3' coding region resulting in a frameshift compared to variant 1. The encoded isoform (4) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK026195, AK290978, AL157394, BC012479, BU620333, DA699562, FJ200481

Consensus CDS

CCDS91296.1

UniProtKB/TrEMBL

A0A8Q3SIY4, K9J972

Related

ENSP00000347979.3, ENST00000355740.8

Conserved Domains (1) summary

cd10579
Location:39 → 167

TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)
NM_001410956.1 → NP_001397885.1 tumor necrosis factor receptor superfamily member 6 isoform 5

Status: REVIEWED

Source sequence(s)

AL157394

Consensus CDS

CCDS91297.1

UniProtKB/TrEMBL

A0A8Q3SIR6

Related

ENSP00000512813.1, ENST00000477270.6
NM_152871.4 → NP_690610.1 tumor necrosis factor receptor superfamily member 6 isoform 2 precursor

See identical proteins and their annotated locations for NP_690610.1

Status: REVIEWED

Description

Transcript Variant: This variant (2), also known as FasdeltaTM or soluble FAS, lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal region, compared to isoform 1.

Source sequence(s)

AK026195, AK290978, AL157394, BC012479, BU620333, DA699562, Z47993

Consensus CDS

CCDS7394.1

UniProtKB/TrEMBL

A0A1B0QZF0, Q6ICT6

Related

ENSP00000349896.2, ENST00000357339.7

Conserved Domains (2) summary

cd08316
Location:205 → 298

Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6

cd10579
Location:39 → 167

TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)
NM_152872.4 → NP_690611.1 tumor necrosis factor receptor superfamily member 6 isoform 3 precursor

See identical proteins and their annotated locations for NP_690611.1

Status: REVIEWED

Description

Transcript Variant: This variant (3), also known as FASExo8Del, lacks a coding segment, which leads to a translation frameshift, compared to variant 1. The resulting isoform (3) contains a distinct and shorter C-terminus, as compared to isoform 1.

Source sequence(s)

AK026195, AL157394, BC012479, BU620333, DA699562, Z66556

Consensus CDS

CCDS7395.1

UniProtKB/TrEMBL

A0A8V8TKN4

Related

ENSP00000347426.2, ENST00000355279.2

Conserved Domains (1) summary

cd10579
Location:39 → 167

TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

RNA

NR_028033.4 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two alternate coding exons compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and likely is not translated.

Source sequence(s)

AK026195, AK290978, AL157394, BC012479, BU620333, DA699562, Z70520

Related

ENST00000492756.7
NR_028034.4 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks three alternate exons compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and likely is not translated.

Source sequence(s)

AK026195, AK290978, AL157394, BC012479, BU620333, DA699562, Z47995
NR_028035.4 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks two alternate exons compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and likely is not translated.

Source sequence(s)

AK026195, AK290978, AL157394, BC012479, BU620333, DA699562, Z47994
NR_028036.4 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks an alternate coding exon compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and likely is not translated.

Source sequence(s)

AK026195, AK290978, AL157394, BC012479, BU620333, DA699562, Z70519
NR_135313.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AK026195, AK290978, AL157394, BC012479, BU620333, DA699562, X83492

Related

ENST00000696781.1
NR_135314.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AK026195, AK290978, AK311424, AL157394, BC012479, BU620333, DA040126
NR_135315.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AK026195, AK290978, AK311424, AL157394, AV715411, BC012479, BU620333

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

88964050..89017059

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006717819.4 → XP_006717882.1 tumor necrosis factor receptor superfamily member 6 isoform X3

See identical proteins and their annotated locations for XP_006717882.1

UniProtKB/TrEMBL

A0A1B0QZF0, Q59FU8, Q6ICT6

Conserved Domains (2) summary

cd08316
Location:253 → 346

Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6

cd10579
Location:66 → 194

TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)
XM_011539764.3 → XP_011538066.1 tumor necrosis factor receptor superfamily member 6 isoform X1

UniProtKB/TrEMBL

A0A1B0QZF0, Q6ICT6

Conserved Domains (2) summary

cd08316
Location:280 → 373

Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6

cd10579
Location:93 → 221

TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)
XM_011539765.3 → XP_011538067.1 tumor necrosis factor receptor superfamily member 6 isoform X2

UniProtKB/TrEMBL

A0A1B0QZF0, Q6ICT6

Conserved Domains (2) summary

cd08316
Location:259 → 352

Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6

cd10579
Location:93 → 221

TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)
XM_047425179.1 → XP_047281135.1 tumor necrosis factor receptor superfamily member 6 isoform X5
XM_047425180.1 → XP_047281136.1 tumor necrosis factor receptor superfamily member 6 isoform X6
XM_011539766.3 → XP_011538068.1 tumor necrosis factor receptor superfamily member 6 isoform X3

See identical proteins and their annotated locations for XP_011538068.1

UniProtKB/TrEMBL

A0A1B0QZF0, Q59FU8, Q6ICT6

Related

ENSP00000509810.1, ENST00000690268.1

Conserved Domains (2) summary

cd08316
Location:253 → 346

Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6

cd10579
Location:66 → 194

TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)
XM_047425178.1 → XP_047281134.1 tumor necrosis factor receptor superfamily member 6 isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

89847964..89900944

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054365760.1 → XP_054221735.1 tumor necrosis factor receptor superfamily member 6 isoform X3

UniProtKB/TrEMBL

Q59FU8
XM_054365758.1 → XP_054221733.1 tumor necrosis factor receptor superfamily member 6 isoform X1
XM_054365759.1 → XP_054221734.1 tumor necrosis factor receptor superfamily member 6 isoform X2
XM_054365763.1 → XP_054221738.1 tumor necrosis factor receptor superfamily member 6 isoform X5
XM_054365764.1 → XP_054221739.1 tumor necrosis factor receptor superfamily member 6 isoform X6
XM_054365761.1 → XP_054221736.1 tumor necrosis factor receptor superfamily member 6 isoform X3

UniProtKB/TrEMBL

Q59FU8
XM_054365762.1 → XP_054221737.1 tumor necrosis factor receptor superfamily member 6 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_152873.1: Suppressed sequence

Description

NM_152873.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_152874.1: Suppressed sequence

Description

NM_152874.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_152875.1: Suppressed sequence

Description

NM_152875.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_152876.1: Suppressed sequence

Description

NM_152876.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_152877.1: Suppressed sequence

Description

NM_152877.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.