ITGB1 integrin subunit beta 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ITGB1provided by HGNC
Official Full Name: integrin subunit beta 1provided by HGNC
Primary source: HGNC:HGNC:6153
See related: Ensembl:ENSG00000150093 MIM:135630; AllianceGenome:HGNC:6153
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA
Summary: Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in fat (RPKM 292.8), gall bladder (RPKM 214.5) and 25 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10p11.22

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (32900318..32958230, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (32929042..32986969, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (33189246..33247158, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypoxic Upregulation of IER2 Increases Paracrine GMFG Signaling of Endoplasmic Reticulum Stress-CAF to Promote Chordoma Progression via Targeting ITGB1.
Title: Hypoxic Upregulation of IER2 Increases Paracrine GMFG Signaling of Endoplasmic Reticulum Stress-CAF to Promote Chordoma Progression via Targeting ITGB1.
Integrin alphaVbeta1-activated PYK2 promotes the progression of non-small-cell lung cancer via the STAT3-VGF axis.
Title: Integrin αVβ1-activated PYK2 promotes the progression of non-small-cell lung cancer via the STAT3-VGF axis.
alpha9beta1 integrin & its ligands as new potential biomarkers in FMF.
Title: α9β1 integrin & its ligands as new potential biomarkers in FMF.
Tetraspanin 3 promotes NSCLC cell proliferation via regulation of beta1 integrin intracellular recycling.
Title: Tetraspanin 3 promotes NSCLC cell proliferation via regulation of β1 integrin intracellular recycling.
The VLA-4 integrin is constitutively active in circulating chronic lymphocytic leukemia cells via BCR autonomous signaling: a novel anchor-independent mechanism exploiting soluble blood-borne ligands.
Title: The VLA-4 integrin is constitutively active in circulating chronic lymphocytic leukemia cells via BCR autonomous signaling: a novel anchor-independent mechanism exploiting soluble blood-borne ligands.
Immunohistochemical analysis of CD9, CD29 and epithelial to mesenchymal transition in triple-negative breast cancer.
Title: Immunohistochemical analysis of CD9, CD29 and epithelial to mesenchymal transition in triple-negative breast cancer.
RUNX1/miR-429 feedback loop promotes growth, metastasis, and epithelial-mesenchymal transition in oral squamous cell carcinoma by targeting ITGB1.
Title: RUNX1/miR-429 feedback loop promotes growth, metastasis, and epithelial-mesenchymal transition in oral squamous cell carcinoma by targeting ITGB1.
ACSL4-Mediated Membrane Phospholipid Remodeling Induces Integrin beta1 Activation to Facilitate Triple-Negative Breast Cancer Metastasis.
Title: ACSL4-Mediated Membrane Phospholipid Remodeling Induces Integrin β1 Activation to Facilitate Triple-Negative Breast Cancer Metastasis.
ADAM12-Generated Basigin Ectodomain Binds beta1 Integrin and Enhances the Expression of Cancer-Related Extracellular Matrix Proteins.
Title: ADAM12-Generated Basigin Ectodomain Binds β1 Integrin and Enhances the Expression of Cancer-Related Extracellular Matrix Proteins.
Blocking the angiopoietin-2-dependent integrin beta-1 signaling axis abrogates small cell lung cancer invasion and metastasis.
Title: Blocking the angiopoietin-2-dependent integrin β-1 signaling axis abrogates small cell lung cancer invasion and metastasis.

Submit: New GeneRIF Correction See all GeneRIFs (1042)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association scan of trait depression. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	SLIT2 inhibits HIV-1 gp120-induced lymphatic hyperpermeability by blocking the interaction between Robo4 and integrin alpha5beta1 in human lymphatic endothelial cells	PubMed
	env	HIV-1 Tat complexes with gp120 to induce entry of VLPs expressing R5- or X4-tropic Env into MDDCs, which involves alpha5beta1, alpha5beta3, and alpha5beta5 integrins	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 interacts with ITGB1; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix	PubMed
Nef	nef	The yeast two-hybrid screen and the coimmunoprecipitation analysis identify the HIV-1 Nef interacting human protein integrin, beta 1 (ITGB1) in cells	PubMed
Tat	tat	HIV-1 Tat-induced inhibition of IFN-gamma release is regulated by the interaction of Tat-RGD domain with alpha5beta1 and alpha5beta3 integrins in CD8+ T cells	PubMed
	tat	Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution	PubMed
	tat	HIV-1 Tat complexes with gp120 to induce entry of VLPs expressing R5- or X4-tropic Env into MDDCs, which involves alpha5beta1, alpha5beta3, and alpha5beta5 integrins	PubMed
	tat	The KKR spatial domain (Lys12, Lys41, and Arg78) in HIV-1 Tat contributes to Tat-mediated cell adhesion via integrin beta 1 activation in a cell surface HSPG-dependent manner	PubMed
	tat	Sulfated polymannuroguluronate, a novel anti-AIDS drug candidate, greatly arrests Tat-driven KDR phosphorylation and blocks the interaction between Tat and integrin beta1, thus inhibiting the phosphorylation of the kinases FAK, paxillin and MAPKs	PubMed
	tat	HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells requires CXCR4, VEGFR1, and beta-integrins	PubMed
	tat	HIV-1 Tat induces angiogenesis and cooperates in the development of AIDS-associated Kaposi sarcoma as a result of interactions with integrins alpha-5-beta-1 and alpha-v-beta 3	PubMed
	tat	The arginine-glycine-aspartic acid (RGD) sequence present at the carboxy-terminal of HIV-1 Tat mediates vascular cell and monocyte migration and invasion by binding to the alpha-5-beta-1 and alpha-v-beta-3 integrins	PubMed
	tat	HIV-1 Tat induced monocyte invasion is inhibited by anti-beta integrin Ab or tissue inhibitor of metalloproteinase (TIMP), indicating an interaction with beta integrins and TIMP	PubMed
	tat	IFN-gamma interacts with HIV-1 Tat to induce endothelial cells to proliferate and invade the extracellular matrix by upregulating the receptors for Tat (integrins alpha-5-beta-1 and alpha-v-beta-3), suggesting Tat and IFN-gamma play major roles in AIDS-KS	PubMed
	tat	Interaction of HIV-1 Tat with alpha 5, beta 1, and alpha v subunits of surface integrin receptors mediates activation of CD4+ T cells	PubMed
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of integrin, beta 1 (ITGB1, fibronectin receptor, CD29) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

G15908 (e-PCR)
- UniSTS:78095

D10S2354 (e-PCR)
- UniSTS:64314

RH47472 (e-PCR)
- UniSTS:84058

NoName (e-PCR)
- UniSTS:486749

D10S2370 (e-PCR)
- UniSTS:57957

GDB:181546 (e-PCR)
- UniSTS:155272

ITGB1_1823 (e-PCR)
- UniSTS:277394

RH47140 (e-PCR)
- UniSTS:89260

PMC59887P1 (e-PCR)
- UniSTS:273375

STS-M34189 (e-PCR)
- UniSTS:34037

RH40308 (e-PCR)
- UniSTS:92921

SHGC-32719 (e-PCR)
- UniSTS:167675

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
contributes_to C-X3-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to C-X3-C chemokine binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables collagen binding involved in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
enables collagen binding involved in cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
enables coreceptor activity	TAS Traceable Author Statement more info	PubMed
enables fibronectin binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibronectin binding	IDA Inferred from Direct Assay more info	PubMed
enables fibronectin binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	TAS Traceable Author Statement more info	PubMed
enables integrin binding involved in cell-matrix adhesion	ISS Inferred from Sequence or Structural Similarity more info
contributes_to laminin binding	IBA Inferred from Biological aspect of Ancestor more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables virus receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IC Inferred by Curator more info	PubMed
involved_in CD40 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in axon extension	IEA Inferred from Electronic Annotation more info
involved_in basement membrane organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium-independent cell-matrix adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cardiac cell fate specification	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle cell myoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	TAS Traceable Author Statement more info	PubMed
involved_in cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell projection organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by integrin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-matrix adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in cell-substrate adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular defense response	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to low-density lipoprotein particle stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	NAS Non-traceable Author Statement more info	PubMed
involved_in formation of radial glial scaffolds	IEA Inferred from Electronic Annotation more info
involved_in germ cell migration	IEA Inferred from Electronic Annotation more info
involved_in heterotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	TAS Traceable Author Statement more info	PubMed
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in leukocyte cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in leukocyte cell-cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in leukocyte tethering or rolling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of blood-brain barrier	NAS Non-traceable Author Statement more info	PubMed
involved_in mesodermal cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in myoblast fate specification	IEA Inferred from Electronic Annotation more info
involved_in myoblast fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of anoikis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fibroblast migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of glutamate uptake involved in transmission of nerve impulse	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vascular endothelial growth factor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of wound healing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within_negative_effect reactive gliosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of collagen catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of inward rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within_negative_effect regulation of spontaneous synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synapse pruning	IEA Inferred from Electronic Annotation more info
involved_in response to muscle activity	IEA Inferred from Electronic Annotation more info
involved_in sarcomere organization	IEA Inferred from Electronic Annotation more info
NOT involved_in stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info
NOT involved_in transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual learning	IEA Inferred from Electronic Annotation more info
involved_in wound healing, spreading of epidermal cells	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
located_in cell surface	HDA more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cerebellar climbing fiber to Purkinje cell synapse	IEA Inferred from Electronic Annotation more info
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	TAS Traceable Author Statement more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	HDA more info	PubMed
colocalizes_with focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in glial cell projection	ISS Inferred from Sequence or Structural Similarity more info
part_of integrin alpha1-beta1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alpha1-beta1 complex	NAS Non-traceable Author Statement more info	PubMed
part_of integrin alpha10-beta1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alpha10-beta1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of integrin alpha11-beta1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alpha2-beta1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alpha2-beta1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of integrin alpha3-beta1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alpha4-beta1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of integrin alpha4-beta1 complex	TAS Traceable Author Statement more info	PubMed
part_of integrin alpha5-beta1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alpha5-beta1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of integrin alpha6-beta1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of integrin alpha7-beta1 complex	IEA Inferred from Electronic Annotation more info
part_of integrin alpha8-beta1 complex	TAS Traceable Author Statement more info	PubMed
part_of integrin alpha9-beta1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of integrin alpha9-beta1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of integrin alphav-beta1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in intercalated disc	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath abaxonal region	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in ruffle	TAS Traceable Author Statement more info	PubMed
colocalizes_with ruffle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	NAS Non-traceable Author Statement more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: integrin beta-1

Names: glycoprotein IIa; integrin VLA-4 beta subunit; integrin beta 1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); very late activation protein, beta polypeptide

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029012.1 RefSeqGene

Range

5136..63048

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002211.4 → NP_002202.2 integrin beta-1 isoform 1A precursor

See identical proteins and their annotated locations for NP_002202.2

Status: REVIEWED

Description

Transcript Variant: This variant (1A) represents the longest transcript and encodes the shorter isoform (1A). Both variants 1A and 1E encode the same isoform.

Source sequence(s)

AI261443, BM973433, BX537407, CX868374, DB063946, DB292597

Consensus CDS

CCDS7174.1

UniProtKB/Swiss-Prot

A8K6N2, D3DRX9, D3DRY3, D3DRY4, D3DRY5, P05556, P78466, P78467, Q13089, Q13090, Q13091, Q13212, Q14622, Q14647, Q29RW2, Q7Z3V1, Q8WUM6

UniProtKB/TrEMBL

E7EUI6

Related

ENSP00000303351.3, ENST00000302278.8

Conserved Domains (5) summary

smart00187
Location:34 → 464

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:640 → 727

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:755 → 795

Integrin_b_cyt; Integrin beta cytoplasmic domain

pfam18372
Location:466 → 495

I-EGF_1; Integrin beta epidermal growth factor like domain 1

NF033759
Location:472 → 650

exchanger_TraA; outer membrane exchange protein TraA
NM_033668.2 → NP_391988.1 integrin beta-1 isoform 1D precursor

See identical proteins and their annotated locations for NP_391988.1

Status: REVIEWED

Description

Transcript Variant: This variant (1D) includes an alternate exon, known as exon D, which results in a frameshift in the 3' coding region, compared to variant 1A. The resulting isoform (1D) has a distinct and longer C-terminus, compared to isoform 1A. This variant lacks full-length transcript support; its exon combination is predicted based on partial human transcript alignments, homologous transcript alignments including full-length cow mRNA BC114107.1, and data in the literature, including PMIDs 7544298, 7545396, 8567725 and 11779688, which consider this to be a functionally significant variant. This variant lacks a 5' UTR due to alternative splicing choices upstream of the CDS, and uncertainty about which alternative promoter is used.

Source sequence(s)

AI261443, AL365203, AL710802, BM791591, BM973433, BX537407, CX871886, DA600874

UniProtKB/TrEMBL

E7EUI6

Related

ENSP00000388694.1, ENST00000423113.6

Conserved Domains (3) summary

pfam00362
Location:34 → 464

Integrin_beta; Integrin, beta chain

pfam07965
Location:640 → 727

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:757 → 796

Integrin_b_cyt; Integrin beta cytoplasmic domain
NM_133376.3 → NP_596867.1 integrin beta-1 isoform 1A precursor

See identical proteins and their annotated locations for NP_596867.1

Status: REVIEWED

Description

Transcript Variant: This variant (1E) differs in the 5' UTR compared to variant 1A. Both variants 1A and 1E encode the same isoform (1A). There are no publicly available full-length transcripts representing this variant; it is supported by partial transcript alignments and by full-length cloning and sequencing in PMID:8444890.

Source sequence(s)

AI261443, AL365203, BM973433, BX537407, CX868374, DB292597

Consensus CDS

CCDS7174.1

UniProtKB/Swiss-Prot

A8K6N2, D3DRX9, D3DRY3, D3DRY4, D3DRY5, P05556, P78466, P78467, Q13089, Q13090, Q13091, Q13212, Q14622, Q14647, Q29RW2, Q7Z3V1, Q8WUM6

UniProtKB/TrEMBL

E7EUI6

Related

ENSP00000379350.2, ENST00000396033.6

Conserved Domains (5) summary

smart00187
Location:34 → 464

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:640 → 727

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:755 → 795

Integrin_b_cyt; Integrin beta cytoplasmic domain

pfam18372
Location:466 → 495

I-EGF_1; Integrin beta epidermal growth factor like domain 1

NF033759
Location:472 → 650

exchanger_TraA; outer membrane exchange protein TraA

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

32900318..32958230 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

32929042..32986969 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_033666.2: Suppressed sequence

Description

NM_033666.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_033667.2: Suppressed sequence

Description

NM_033667.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_033669.2: Suppressed sequence

Description

NM_033669.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.