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    RRP7 Rrp7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850326, updated on 29-Jun-2024

    Summary

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    Gene symbol
    RRP7
    Gene description
    Rrp7p
    Primary source
    FungiDB:YCL031C
    Locus tag
    YCL031C
    See related
    SGD:S000000536; AllianceGenome:SGD:S000000536; VEuPathDB:YCL031C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables rRNA binding activity. Involved in rRNA processing and ribosomal small subunit assembly. Located in nucleolus. Part of CURI complex and UTP-C complex. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to several human genes including RRP7A (ribosomal RNA processing 7 homolog A). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RRP7 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (64675..65568, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene peptide-methionine (R)-S-oxide reductase Neighboring gene Ste50p Neighboring gene trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase Neighboring gene Bik1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of Rrp7p, an essential yeast protein involved in pre-rRNA processing and ribosome assembly. Baudin-Baillieu A, et al. Mol Cell Biol, 1997 Sep. PMID 9271380, Free PMC Article
    2. Potential interface between ribosomal protein production and pre-rRNA processing. Rudra D, et al. Mol Cell Biol, 2007 Jul. PMID 17452446, Free PMC Article
    3. A Molecular Titration System Coordinates Ribosomal Protein Gene Transcription with Ribosomal RNA Synthesis. Albert B, et al. Mol Cell, 2016 Nov 17. PMID 27818142
    4. An RNA-binding complex involved in ribosome biogenesis contains a protein with homology to tRNA CCA-adding enzyme. Lin J, et al. PLoS Biol, 2013 Oct. PMID 24130456, Free PMC Article
    5. The ribosome biogenesis factor yUtp23/hUTP23 coordinates key interactions in the yeast and human pre-40S particle and hUTP23 contains an essential PIN domain. Wells GR, et al. Nucleic Acids Res, 2017 May 5. PMID 28082392, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosomal small subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CURI complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CURI complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of UTP-C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of UTP-C complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rrp7p
    NP_009899.1
    • Essential protein involved in rRNA processing and ribosome biogenesis; forms a complex with Utp22p; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      64675..65568 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178676.1 → NP_009899.1  TPA: Rrp7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009899.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQY4, P25368
      UniProtKB/TrEMBL
      A0A6A5Q190, A6ZTF9, B3LU51, B5VES7, C7GSY8, C8Z458, G2W9Z4, N1PAP2
      Conserved Domains (2) summary
      cl15166
      Location:176 → 291
      RRP7_like; RRP7 domain ribosomal RNA-processing protein 7 (Rrp7p), ribosomal RNA-processing protein 7 homolog A (Rrp7A), and similar proteins
      cl40585
      Location:12 → 172
      dRRM_Rrp7p; deviant RNA recognition motif (dRRM) in yeast ribosomal RNA-processing protein 7 (Rrp7p) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25368.1

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