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    SUR1 mannosylinositol phosphorylceramide synthase catalytic subunit SUR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856050, updated on 17-May-2024

    Summary

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    Gene symbol
    SUR1
    Gene description
    mannosylinositol phosphorylceramide synthase catalytic subunit SUR1
    Primary source
    FungiDB:YPL057C
    Locus tag
    YPL057C
    See related
    SGD:S000005978; AllianceGenome:SGD:S000005978; VEuPathDB:YPL057C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BCL21; CSG1; LPE15
    Summary
    Enables mannosyltransferase activity. Involved in glycosphingolipid biosynthetic process and mannosyl-inositol phosphorylceramide metabolic process. Located in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SUR1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (451909..453057, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene monothiol glutaredoxin GRX5 Neighboring gene ATP-binding cassette multidrug transporter PDR12 Neighboring gene Lcl1p Neighboring gene Lge1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast lipid analysis and quantification by mass spectrometry. Guan XL, et al. Methods Enzymol, 2010. PMID 20946818
    2. Pleiotropic roles of N-glycans for enzyme activities and stabilities of MIPC synthases, Csh1 and Sur1/Csg1, in Saccharomyces cerevisiae. Uemura S, et al. Glycobiology, 2022 Aug 18. PMID 35713525
    3. Improvement of d-Lactic Acid Production in Saccharomyces cerevisiae Under Acidic Conditions by Evolutionary and Rational Metabolic Engineering. Baek SH, et al. Biotechnol J, 2017 Oct. PMID 28731533
    4. Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis. da Silveira Dos Santos AX, et al. Mol Biol Cell, 2014 Oct 15. PMID 25143408, Free PMC Article
    5. A gene encoding a sphingolipid biosynthesis enzyme determines the sensitivity of Saccharomyces cerevisiae to an antifungal plant defensin from dahlia (Dahlia merckii). Thevissen K, et al. Proc Natl Acad Sci U S A, 2000 Aug 15. PMID 10931938, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pleiotropic roles of N-glycans for enzyme activities and stabilities of MIPC synthases, Csh1 and Sur1/Csg1, in Saccharomyces cerevisiae.
      Title: Pleiotropic roles of N-glycans for enzyme activities and stabilities of MIPC synthases, Csh1 and Sur1/Csg1, in Saccharomyces cerevisiae.
    2. Csg2 has several regulatory functions for Csg1 and Csh1, including stability, transport, and gene expression
      Title: Regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases Csg1 and Csh1 by the Ca2+-binding protein Csg2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol phosphorylceramide mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol phosphorylceramide mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycosphingolipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycosphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inositol phosphoceramide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mannosyl-inositol phosphorylceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mannosyl-inositol phosphorylceramide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mannosylinositol phosphorylceramide synthase catalytic subunit SUR1
    NP_015268.1
    • Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      451909..453057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183871.1 → NP_015268.1  TPA: mannosylinositol phosphorylceramide synthase catalytic subunit SUR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015268.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3V7, P33300
      UniProtKB/TrEMBL
      A0A8H4F6T4, A6ZWJ1, C7GTZ9, C8ZIX3, N1NW47
      Conserved Domains (1) summary
      COG3774
      Location:1 → 322
      OCH1; Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33300.1

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