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Pseudomembranous conjunctivitis

MedGen UID:
102325
•Concept ID:
C0155144
•
Disease or Syndrome
Synonyms: conjunctivitis with pseudomembrane; Pseudomembranous Conjunctivitis; pseudomembranous conjunctivitis
SNOMED CT: Pseudomembranous conjunctivitis (72115001)
 
Monarch Initiative: MONDO:0001217

Definition

Conjunctivitis that is characterized by formation of a pseudomembrane. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPseudomembranous conjunctivitis

Professional guidelines

PubMed

Management of patients with ocular manifestations in vesiculobullous disorders affecting the mouth.
Hansen MS, Klefter ON, Julian HO, Lynge Pedersen AM, Heegaard S
Oral Dis 2017 Oct;23(7):849-853. Epub 2016 Nov 17 doi: 10.1111/odi.12590. PMID: 27717107
Oral steroid therapy as an adjuvant treatment for severe epidemic keratoconjunctivitis in patients younger than 3 years.
Kim SY, Chung YK, Lee YC, Kim SY
Cornea 2015 Feb;34(2):182-7. doi: 10.1097/ICO.0000000000000332. PMID: 25522221
Etiology and diagnosis of neonatal conjunctivitis.
Sandström I
Acta Paediatr Scand 1987 Mar;76(2):221-7. doi: 10.1111/j.1651-2227.1987.tb10451.x. PMID: 3109205

Recent clinical studies

Etiology

Pediatric chronic graft-versus-host disease-related dry eye disease and the diagnostic association of potential clinical findings.
Yagi H, Shimizu E, Yagi R, Uchino M, Kamoi M, Asai K, Tsubota K, Negishi K, Ogawa Y
Sci Rep 2023 Mar 2;13(1):3575. doi: 10.1038/s41598-023-30288-6. PMID: 36864106Free PMC Article
Epidemiology of pseudomembranous conjunctivitis in a tertiary hospital: A 2-year retrospective study.
de-Arriba-Palomero F, Salvá-Palomeque T, de-Arriba-Palomero P, Arnalich-Montiel F
Eur J Ophthalmol 2021 Sep;31(5):2275-2279. Epub 2020 Sep 9 doi: 10.1177/1120672120957581. PMID: 32907398
Bristle Worm-Induced Keratouveitis: A Case Report.
Kirk J, Gunn D, Wong N, Minchin E, Darcy K
Cornea 2020 May;39(5):654-656. doi: 10.1097/ICO.0000000000002225. PMID: 31842040
Plasmapheresis, Intravenous Immunoglobulins, and Autologous Serum Eyedrops in the Acute Eye Complications of Toxic Epidermal Necrolysis.
Pinna A, Nuvoli E, Blasetti F, Posadinu MA, Boscia F
Eur J Ophthalmol 2017 Nov 8;27(6):658-663. doi: 10.5301/ejo.5000923. PMID: 28362052
Visual acuity and anterior segment findings in chronic graft-versus-host disease.
Allan EJ, Flowers ME, Lin MP, Bensinger RE, Martin PJ, Wu MC
Cornea 2011 Dec;30(12):1392-7. doi: 10.1097/ICO.0b013e31820ce6d0. PMID: 21996943

Diagnosis

Chlamydia psittaci -Induced Reactive Infectious Mucocutaneous Eruption With Ocular Involvement.
Gholap RS, Engelmann AR, Munir WM
Eye Contact Lens 2023 Dec 1;49(12):572-574. Epub 2023 Sep 20 doi: 10.1097/ICL.0000000000001042. PMID: 37728867
Pediatric chronic graft-versus-host disease-related dry eye disease and the diagnostic association of potential clinical findings.
Yagi H, Shimizu E, Yagi R, Uchino M, Kamoi M, Asai K, Tsubota K, Negishi K, Ogawa Y
Sci Rep 2023 Mar 2;13(1):3575. doi: 10.1038/s41598-023-30288-6. PMID: 36864106Free PMC Article
Ligneous conjunctivitis mimicking preseptal cellulitis in a 3-month-old infant.
Merlevede V, Ninclaus V, Roels D, Huys L, Callewaert B, Kreps EO
Ophthalmic Genet 2023 Feb;44(1):103-106. Epub 2022 Jun 29 doi: 10.1080/13816810.2022.2092756. PMID: 35769059
Bristle Worm-Induced Keratouveitis: A Case Report.
Kirk J, Gunn D, Wong N, Minchin E, Darcy K
Cornea 2020 May;39(5):654-656. doi: 10.1097/ICO.0000000000002225. PMID: 31842040
External ophthalmomyiasis: a case series and review of ophthalmomyiasis in Turkey.
Özyol P, Özyol E, Sankur F
Int Ophthalmol 2016 Dec;36(6):887-891. Epub 2016 Feb 19 doi: 10.1007/s10792-016-0204-9. PMID: 26895273

Therapy

Plasmapheresis, Intravenous Immunoglobulins, and Autologous Serum Eyedrops in the Acute Eye Complications of Toxic Epidermal Necrolysis.
Pinna A, Nuvoli E, Blasetti F, Posadinu MA, Boscia F
Eur J Ophthalmol 2017 Nov 8;27(6):658-663. doi: 10.5301/ejo.5000923. PMID: 28362052
Cicatrizing Conjunctivitis in a Patient Diagnosed With Drug Reaction With Eosinophilia and Systemic Symptoms/Drug-Induced Hypersensitivity Syndrome but With Features of Stevens-Johnson Syndrome.
Bohm KJ, Ciralsky JB, Harp JL, Bajaj S, Sippel KC
Cornea 2016 Jun;35(6):888-91. doi: 10.1097/ICO.0000000000000845. PMID: 27078005
Rare extrapulmonary complications of Mycoplasma pneumoniae infection.
Dhaliwal K, Enright K
BMJ Case Rep 2016 Feb 1;2016 doi: 10.1136/bcr-2015-214044. PMID: 26837942Free PMC Article
Visual acuity and anterior segment findings in chronic graft-versus-host disease.
Allan EJ, Flowers ME, Lin MP, Bensinger RE, Martin PJ, Wu MC
Cornea 2011 Dec;30(12):1392-7. doi: 10.1097/ICO.0b013e31820ce6d0. PMID: 21996943
Ocular findings in allogeneic stem cell transplantation without total body irradiation.
Kerty E, Vigander K, Flage T, Brinch L
Ophthalmology 1999 Jul;106(7):1334-8. doi: 10.1016/S0161-6420(99)00720-4. PMID: 10406617

Prognosis

Case for conservative management of adenoviral pseudomembranous conjunctivitis.
Gilmour KM, Ramaesh K
BMJ Case Rep 2023 Feb 21;16(2) doi: 10.1136/bcr-2022-253014. PMID: 36810328Free PMC Article
Bristle Worm-Induced Keratouveitis: A Case Report.
Kirk J, Gunn D, Wong N, Minchin E, Darcy K
Cornea 2020 May;39(5):654-656. doi: 10.1097/ICO.0000000000002225. PMID: 31842040
Conjunctival Acute Graft-versus-Host Disease in Adult Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation: A Cohort Study.
Liu YC, Gau JP, Lin PY, Liu CJ, Liu CJ, Liu JH, Fan NW
PLoS One 2016;11(11):e0167129. Epub 2016 Nov 30 doi: 10.1371/journal.pone.0167129. PMID: 27902756Free PMC Article
Visual acuity and anterior segment findings in chronic graft-versus-host disease.
Allan EJ, Flowers ME, Lin MP, Bensinger RE, Martin PJ, Wu MC
Cornea 2011 Dec;30(12):1392-7. doi: 10.1097/ICO.0b013e31820ce6d0. PMID: 21996943
Successful treatment of Stevens-Johnson syndrome with steroid pulse therapy at disease onset.
Araki Y, Sotozono C, Inatomi T, Ueta M, Yokoi N, Ueda E, Kishimoto S, Kinoshita S
Am J Ophthalmol 2009 Jun;147(6):1004-11, 1011.e1. Epub 2009 Mar 14 doi: 10.1016/j.ajo.2008.12.040. PMID: 19285657

Clinical prediction guides

Epidemiology of pseudomembranous conjunctivitis in a tertiary hospital: A 2-year retrospective study.
de-Arriba-Palomero F, Salvá-Palomeque T, de-Arriba-Palomero P, Arnalich-Montiel F
Eur J Ophthalmol 2021 Sep;31(5):2275-2279. Epub 2020 Sep 9 doi: 10.1177/1120672120957581. PMID: 32907398
Plasmapheresis, Intravenous Immunoglobulins, and Autologous Serum Eyedrops in the Acute Eye Complications of Toxic Epidermal Necrolysis.
Pinna A, Nuvoli E, Blasetti F, Posadinu MA, Boscia F
Eur J Ophthalmol 2017 Nov 8;27(6):658-663. doi: 10.5301/ejo.5000923. PMID: 28362052
Visual acuity and anterior segment findings in chronic graft-versus-host disease.
Allan EJ, Flowers ME, Lin MP, Bensinger RE, Martin PJ, Wu MC
Cornea 2011 Dec;30(12):1392-7. doi: 10.1097/ICO.0b013e31820ce6d0. PMID: 21996943
Successful treatment of Stevens-Johnson syndrome with steroid pulse therapy at disease onset.
Araki Y, Sotozono C, Inatomi T, Ueta M, Yokoi N, Ueda E, Kishimoto S, Kinoshita S
Am J Ophthalmol 2009 Jun;147(6):1004-11, 1011.e1. Epub 2009 Mar 14 doi: 10.1016/j.ajo.2008.12.040. PMID: 19285657
Ocular findings in allogeneic stem cell transplantation without total body irradiation.
Kerty E, Vigander K, Flage T, Brinch L
Ophthalmology 1999 Jul;106(7):1334-8. doi: 10.1016/S0161-6420(99)00720-4. PMID: 10406617

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