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Ocular hypertension

MedGen UID:
10423
•Concept ID:
C0028840
•
Disease or Syndrome
Synonyms: Hypertension, Ocular; Hypertensions, Ocular; Ocular Hypertension; Ocular Hypertensions
SNOMED CT: OH - ocular hypertension (4210003); OHT - ocular hypertension (4210003); Ocular hypertension (4210003)
 
Monarch Initiative: MONDO:0006875

Definition

Abnormally high intraocular pressure. [from NCI]

Professional guidelines

PubMed

Pathophysiology and management of glaucoma and ocular hypertension related to trauma.
Razeghinejad R, Lin MM, Lee D, Katz LJ, Myers JS
Surv Ophthalmol 2020 Sep-Oct;65(5):530-547. Epub 2020 Feb 11 doi: 10.1016/j.survophthal.2020.02.003. PMID: 32057763
Pharmacological management of primary open-angle glaucoma: second-line options and beyond.
Webers CA, Beckers HJ, Nuijts RM, Schouten JS
Drugs Aging 2008;25(9):729-59. doi: 10.2165/00002512-200825090-00002. PMID: 18729546
Current management of glaucoma.
Schwartz K, Budenz D
Curr Opin Ophthalmol 2004 Apr;15(2):119-26. doi: 10.1097/00055735-200404000-00011. PMID: 15021223

Recent clinical studies

Etiology

Gene therapies and gene product-based drug candidates for normalizing and preserving tissue functions in animal models of ocular hypertension and glaucoma.
Sharif NA
Mol Aspects Med 2023 Dec;94:101218. Epub 2023 Nov 15 doi: 10.1016/j.mam.2023.101218. PMID: 37976898
Impact of self-tonometry on glaucoma treatment decision.
Quérat L, Chen E
Acta Ophthalmol 2023 Mar;101(2):e246-e251. Epub 2022 Sep 22 doi: 10.1111/aos.15256. PMID: 36147012
Uveitic Ocular Hypertension and Glaucoma.
Cunningham ET Jr, Zierhut M
Ocul Immunol Inflamm 2017 Dec;25(6):737-739. doi: 10.1080/09273948.2017.1415077. PMID: 29265966
Glaucoma Suspect: Diagnosis and Management.
Chang RT, Singh K
Asia Pac J Ophthalmol (Phila) 2016 Jan-Feb;5(1):32-7. doi: 10.1097/APO.0000000000000173. PMID: 26886117
Angle-closure glaucoma.
Patel K, Patel S
Dis Mon 2014 Jun;60(6):254-62. doi: 10.1016/j.disamonth.2014.03.005. PMID: 24906670

Diagnosis

Impact of self-tonometry on glaucoma treatment decision.
Quérat L, Chen E
Acta Ophthalmol 2023 Mar;101(2):e246-e251. Epub 2022 Sep 22 doi: 10.1111/aos.15256. PMID: 36147012
Current intravitreal therapy and ocular hypertension: A review.
Sudhalkar A, Bilgic A, Vasavada S, Kodjikian L, Mathis T, de Ribot FM, Papakostas T, Vasavada V, Vasavada V, Srivastava S, Bhojwani D, Ghia P, Sudhalkar A
Indian J Ophthalmol 2021 Feb;69(2):236-243. doi: 10.4103/ijo.IJO_1028_20. PMID: 33463565Free PMC Article
Uveitic Ocular Hypertension and Glaucoma.
Cunningham ET Jr, Zierhut M
Ocul Immunol Inflamm 2017 Dec;25(6):737-739. doi: 10.1080/09273948.2017.1415077. PMID: 29265966
Angle-closure glaucoma.
Patel K, Patel S
Dis Mon 2014 Jun;60(6):254-62. doi: 10.1016/j.disamonth.2014.03.005. PMID: 24906670
The economic burden of glaucoma and ocular hypertension: implications for patient management: a review.
Rouland JF, Berdeaux G, Lafuma A
Drugs Aging 2005;22(4):315-21. doi: 10.2165/00002512-200522040-00004. PMID: 15839720

Therapy

Laser in Glaucoma and Ocular Hypertension (LiGHT) Trial: Six-Year Results of Primary Selective Laser Trabeculoplasty versus Eye Drops for the Treatment of Glaucoma and Ocular Hypertension.
Gazzard G, Konstantakopoulou E, Garway-Heath D, Adeleke M, Vickerstaff V, Ambler G, Hunter R, Bunce C, Nathwani N, Barton K; LiGHT Trial Study Group
Ophthalmology 2023 Feb;130(2):139-151. Epub 2022 Sep 17 doi: 10.1016/j.ophtha.2022.09.009. PMID: 36122660
Topical corticosteroids for dry eye.
Liu SH, Saldanha IJ, Abraham AG, Rittiphairoj T, Hauswirth S, Gregory D, Ifantides C, Li T
Cochrane Database Syst Rev 2022 Oct 21;10(10):CD015070. doi: 10.1002/14651858.CD015070.pub2. PMID: 36269562Free PMC Article
Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial.
Gazzard G, Konstantakopoulou E, Garway-Heath D, Garg A, Vickerstaff V, Hunter R, Ambler G, Bunce C, Wormald R, Nathwani N, Barton K, Rubin G, Buszewicz M; LiGHT Trial Study Group
Lancet 2019 Apr 13;393(10180):1505-1516. Epub 2019 Mar 9 doi: 10.1016/S0140-6736(18)32213-X. PMID: 30862377Free PMC Article
Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glaucoma: A Systematic Review and Network Meta-analysis.
Li T, Lindsley K, Rouse B, Hong H, Shi Q, Friedman DS, Wormald R, Dickersin K
Ophthalmology 2016 Jan;123(1):129-40. Epub 2015 Oct 31 doi: 10.1016/j.ophtha.2015.09.005. PMID: 26526633Free PMC Article
The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.
Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Gordon MO
Arch Ophthalmol 2002 Jun;120(6):701-13; discussion 829-30. doi: 10.1001/archopht.120.6.701. PMID: 12049574

Prognosis

LONG-TERM INCIDENCE AND RISK FACTORS OF OCULAR HYPERTENSION FOLLOWING DEXAMETHASONE-IMPLANT INJECTIONS: THE SAFODEX-2 STUDY.
Rezkallah A, Mathis T, Abukhashabah A, Voirin N, Malclès A, Agard É, Lereuil T, Denis P, Dot C, Kodjikian L
Retina 2021 Jul 1;41(7):1438-1445. doi: 10.1097/IAE.0000000000003080. PMID: 33315814
Do we need day-1 postoperative follow-up after cataract surgery?
Grzybowski A, Kanclerz P
Graefes Arch Clin Exp Ophthalmol 2019 May;257(5):855-861. Epub 2018 Dec 19 doi: 10.1007/s00417-018-04210-0. PMID: 30569320
Incidence and risk factors for post-penetrating keratoplasty glaucoma: A systematic review and meta-analysis.
Wu S, Xu J
PLoS One 2017;12(4):e0176261. Epub 2017 Apr 21 doi: 10.1371/journal.pone.0176261. PMID: 28430806Free PMC Article
Angle-closure glaucoma.
Patel K, Patel S
Dis Mon 2014 Jun;60(6):254-62. doi: 10.1016/j.disamonth.2014.03.005. PMID: 24906670
The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.
Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Gordon MO
Arch Ophthalmol 2002 Jun;120(6):701-13; discussion 829-30. doi: 10.1001/archopht.120.6.701. PMID: 12049574

Clinical prediction guides

Current intravitreal therapy and ocular hypertension: A review.
Sudhalkar A, Bilgic A, Vasavada S, Kodjikian L, Mathis T, de Ribot FM, Papakostas T, Vasavada V, Vasavada V, Srivastava S, Bhojwani D, Ghia P, Sudhalkar A
Indian J Ophthalmol 2021 Feb;69(2):236-243. doi: 10.4103/ijo.IJO_1028_20. PMID: 33463565Free PMC Article
Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial.
Gazzard G, Konstantakopoulou E, Garway-Heath D, Garg A, Vickerstaff V, Hunter R, Ambler G, Bunce C, Wormald R, Nathwani N, Barton K, Rubin G, Buszewicz M; LiGHT Trial Study Group
Lancet 2019 Apr 13;393(10180):1505-1516. Epub 2019 Mar 9 doi: 10.1016/S0140-6736(18)32213-X. PMID: 30862377Free PMC Article
Central corneal thickness in glaucoma.
Sng CC, Ang M, Barton K
Curr Opin Ophthalmol 2017 Mar;28(2):120-126. doi: 10.1097/ICU.0000000000000335. PMID: 27764022
Cataract surgery and intraocular pressure.
Melancia D, Abegão Pinto L, Marques-Neves C
Ophthalmic Res 2015;53(3):141-8. Epub 2015 Mar 7 doi: 10.1159/000377635. PMID: 25765255
The future of glaucoma clinics.
Morley AM, Murdoch I
Br J Ophthalmol 2006 May;90(5):640-5. doi: 10.1136/bjo.2005.085522. PMID: 16622096Free PMC Article

Recent systematic reviews

Topical corticosteroids for dry eye.
Liu SH, Saldanha IJ, Abraham AG, Rittiphairoj T, Hauswirth S, Gregory D, Ifantides C, Li T
Cochrane Database Syst Rev 2022 Oct 21;10(10):CD015070. doi: 10.1002/14651858.CD015070.pub2. PMID: 36269562Free PMC Article
Rho kinase inhibitor for primary open-angle glaucoma and ocular hypertension.
Clement Freiberg J, von Spreckelsen A, Kolko M, Azuara-Blanco A, Virgili G
Cochrane Database Syst Rev 2022 Jun 10;6(6):CD013817. doi: 10.1002/14651858.CD013817.pub2. PMID: 35686679Free PMC Article
Alcohol, Intraocular Pressure, and Open-Angle Glaucoma: A Systematic Review and Meta-analysis.
Stuart KV, Madjedi K, Luben RN, Chua SYL, Warwick AN, Chia M, Pasquale LR, Wiggs JL, Kang JH, Hysi PG, Tran JH, Foster PJ, Khawaja AP; Modifiable Risk Factors for Glaucoma Collaboration
Ophthalmology 2022 Jun;129(6):637-652. Epub 2022 Jan 31 doi: 10.1016/j.ophtha.2022.01.023. PMID: 35101531Free PMC Article
Topical medication instillation techniques for glaucoma.
Xu L, Wang X, Wu M
Cochrane Database Syst Rev 2017 Feb 20;2(2):CD010520. doi: 10.1002/14651858.CD010520.pub2. PMID: 28218404Free PMC Article
Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glaucoma: A Systematic Review and Network Meta-analysis.
Li T, Lindsley K, Rouse B, Hong H, Shi Q, Friedman DS, Wormald R, Dickersin K
Ophthalmology 2016 Jan;123(1):129-40. Epub 2015 Oct 31 doi: 10.1016/j.ophtha.2015.09.005. PMID: 26526633Free PMC Article

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