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Disorder of orbital region

MedGen UID:
5092
•Concept ID:
C0015397
•
Disease or Syndrome
Synonym: Disease of orbital region
SNOMED CT: Disorder of eye (371405004); Disorder of eye region (371409005); Disease of eyeball (371405004); Disorder of globe (371405004); Disorder of eyeball (371405004); Ophthalmological disorder (371409005); Disorder of orbital region (371409005); Eye disorder (371405004); Disorder of eye proper (371405004)
 
Monarch Initiative: MONDO:0002022

Definition

A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Disorder of orbital region

Professional guidelines

PubMed

Glaucoma in Adults-Screening, Diagnosis, and Management: A Review.
Stein JD, Khawaja AP, Weizer JS
JAMA 2021 Jan 12;325(2):164-174. doi: 10.1001/jama.2020.21899. PMID: 33433580
Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria.
Höglinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Nilsson C, Whitwell JL, Arzberger T, Englund E, Gelpi E, Giese A, Irwin DJ, Meissner WG, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Antonini A, Bhatia KP, Bordelon Y, Compta Y, Corvol JC, Colosimo C, Dickson DW, Dodel R, Ferguson L, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris HR, Nestor P, Oertel WH, Poewe W, Rabinovici G, Rowe JB, Schellenberg GD, Seppi K, van Eimeren T, Wenning GK, Boxer AL, Golbe LI, Litvan I; Movement Disorder Society-endorsed PSP Study Group
Mov Disord 2017 Jun;32(6):853-864. Epub 2017 May 3 doi: 10.1002/mds.26987. PMID: 28467028Free PMC Article
International consensus diagnostic criteria for neuromyelitis optica spectrum disorders.
Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A, Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG; International Panel for NMO Diagnosis
Neurology 2015 Jul 14;85(2):177-89. Epub 2015 Jun 19 doi: 10.1212/WNL.0000000000001729. PMID: 26092914Free PMC Article

Recent clinical studies

Etiology

Corticosteroids in ophthalmology: drug delivery innovations, pharmacology, clinical applications, and future perspectives.
Gaballa SA, Kompella UB, Elgarhy O, Alqahtani AM, Pierscionek B, Alany RG, Abdelkader H
Drug Deliv Transl Res 2021 Jun;11(3):866-893. doi: 10.1007/s13346-020-00843-z. PMID: 32901367
Systemic lupus erythematosus and ocular involvement: an overview.
Dammacco R
Clin Exp Med 2018 May;18(2):135-149. Epub 2017 Dec 14 doi: 10.1007/s10238-017-0479-9. PMID: 29243035
Epidemiology of blindness in children.
Solebo AL, Teoh L, Rahi J
Arch Dis Child 2017 Sep;102(9):853-857. Epub 2017 May 2 doi: 10.1136/archdischild-2016-310532. PMID: 28465303
Vitreous floaters: Etiology, diagnostics, and management.
Milston R, Madigan MC, Sebag J
Surv Ophthalmol 2016 Mar-Apr;61(2):211-27. Epub 2015 Dec 8 doi: 10.1016/j.survophthal.2015.11.008. PMID: 26679984
The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole.
Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P
Ophthalmology 2013 Dec;120(12):2611-2619. Epub 2013 Sep 17 doi: 10.1016/j.ophtha.2013.07.042. PMID: 24053995

Diagnosis

Ophthalmic Emergencies for the Clinician.
Shah SM, Khanna CL
Mayo Clin Proc 2020 May;95(5):1050-1058. doi: 10.1016/j.mayocp.2020.03.018. PMID: 32370836
Why Biomarkers?
Asbell P
Eye Contact Lens 2020 Mar;46 Suppl 2:S51-S52. doi: 10.1097/ICL.0000000000000692. PMID: 32150134
Ocular complications of atopic dermatitis.
Hsu JI, Pflugfelder SC, Kim SJ
Cutis 2019 Sep;104(3):189-193. PMID: 31675394
Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Vitreomacular traction syndrome.
Shao L, Wei W
Chin Med J (Engl) 2014;127(8):1566-71. PMID: 24762607

Therapy

Trehalose for Ocular Surface Health.
Laihia J, Kaarniranta K
Biomolecules 2020 May 25;10(5) doi: 10.3390/biom10050809. PMID: 32466265Free PMC Article
Retinal Neuroprotection: Overcoming the Translational Roadblocks.
Wubben TJ, Besirli CG, Johnson MW, Zacks DN
Am J Ophthalmol 2018 Aug;192:xv-xxii. Epub 2018 Apr 25 doi: 10.1016/j.ajo.2018.04.012. PMID: 29702074
Therapeutic potentials of short interfering RNAs.
Tam C, Wong JH, Cheung RCF, Zuo T, Ng TB
Appl Microbiol Biotechnol 2017 Oct;101(19):7091-7111. Epub 2017 Aug 8 doi: 10.1007/s00253-017-8433-z. PMID: 28791440
Sirolimus for Retinal and Uveitic Diseases.
Agarwal A, Rajagopalan N, Hassan M, Sadiq MA, Soliman MK, Afridi R, Sepah YJ, Nguyen QD
Dev Ophthalmol 2016;55:276-81. Epub 2015 Oct 26 doi: 10.1159/000438951. PMID: 26501229
Interventions for intermittent exotropia.
Hatt SR, Gnanaraj L
Cochrane Database Syst Rev 2013 May 31;2013(5):CD003737. doi: 10.1002/14651858.CD003737.pub3. PMID: 23728647Free PMC Article

Prognosis

Toxic anterior segment syndrome-an updated review.
Park CY, Lee JK, Chuck RS
BMC Ophthalmol 2018 Oct 25;18(1):276. doi: 10.1186/s12886-018-0939-3. PMID: 30359246Free PMC Article
Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Ocular leprosy.
Grzybowski A, Nita M, Virmond M
Clin Dermatol 2015 Jan-Feb;33(1):79-89. doi: 10.1016/j.clindermatol.2014.07.003. PMID: 25432813
Ocular emergencies.
Hodge C, Lawless M
Aust Fam Physician 2008 Jul;37(7):506-9. PMID: 18592066
Presumed histoplasmosis.
van Den Heuvel JP, Baarsma GS, Zahn KJ
Doc Ophthalmol 1977 Sep 30;44(1):105-11. doi: 10.1007/BF00171461. PMID: 923400

Clinical prediction guides

Genetic prediction of myopia: prospects and challenges.
Guggenheim JA, Ghorbani Mojarrad N, Williams C, Flitcroft DI
Ophthalmic Physiol Opt 2017 Sep;37(5):549-556. doi: 10.1111/opo.12403. PMID: 28836387
International photographic classification and grading system for myopic maculopathy.
Ohno-Matsui K, Kawasaki R, Jonas JB, Cheung CM, Saw SM, Verhoeven VJ, Klaver CC, Moriyama M, Shinohara K, Kawasaki Y, Yamazaki M, Meuer S, Ishibashi T, Yasuda M, Yamashita H, Sugano A, Wang JJ, Mitchell P, Wong TY; META-analysis for Pathologic Myopia (META-PM) Study Group
Am J Ophthalmol 2015 May;159(5):877-83.e7. Epub 2015 Jan 26 doi: 10.1016/j.ajo.2015.01.022. PMID: 25634530
Vitreomacular traction syndrome.
Shao L, Wei W
Chin Med J (Engl) 2014;127(8):1566-71. PMID: 24762607
Understanding and using sensitivity, specificity and predictive values.
Parikh R, Mathai A, Parikh S, Chandra Sekhar G, Thomas R
Indian J Ophthalmol 2008 Jan-Feb;56(1):45-50. doi: 10.4103/0301-4738.37595. PMID: 18158403Free PMC Article
Criteria for diagnosis of Behçet's disease. International Study Group for Behçet's Disease.
Lancet 1990 May 5;335(8697):1078-80. PMID: 1970380

Recent systematic reviews

Interventions recommended for myopia prevention and control among children and adolescents in China: a systematic review.
Zhu Z, Chen Y, Tan Z, Xiong R, McGuinness MB, Müller A
Br J Ophthalmol 2023 Feb;107(2):160-166. Epub 2021 Nov 29 doi: 10.1136/bjophthalmol-2021-319306. PMID: 34844916
Vitamin D and Ocular Diseases: A Systematic Review.
Chan HN, Zhang XJ, Ling XT, Bui CH, Wang YM, Ip P, Chu WK, Chen LJ, Tham CC, Yam JC, Pang CP
Int J Mol Sci 2022 Apr 11;23(8) doi: 10.3390/ijms23084226. PMID: 35457041Free PMC Article
Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study.
GBD 2019 Blindness and Vision Impairment Collaborators; Vision Loss Expert Group of the Global Burden of Disease Study
Lancet Glob Health 2021 Feb;9(2):e144-e160. Epub 2020 Dec 1 doi: 10.1016/S2214-109X(20)30489-7. PMID: 33275949Free PMC Article
Retinal detachment.
Steel D
BMJ Clin Evid 2014 Mar 3;2014 PMID: 24807890Free PMC Article
Conjunctivitis: a systematic review of diagnosis and treatment.
Azari AA, Barney NP
JAMA 2013 Oct 23;310(16):1721-9. doi: 10.1001/jama.2013.280318. PMID: 24150468Free PMC Article

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