U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Myxoid liposarcoma

MedGen UID:
104903
•Concept ID:
C0206634
•
Neoplastic Process
Synonyms: Liposarcoma, Myxoid; Liposarcoma, Round Cell; Liposarcomas, Myxoid; Myxoid Liposarcoma; Myxoid Liposarcomas; Round Cell Liposarcoma; Round Cell Liposarcomas
SNOMED CT: Myxoid liposarcoma (404069006); Myxoid liposarcoma (27849002); Myxoliposarcoma (27849002)
 
HPO: HP:0012268
Monarch Initiative: MONDO:0013280
OMIM®: 613488

Definition

Myxoid liposarcoma is a soft tissue tumor that tends to occur in the limbs (especially the thigh) of patients ranging in age from 35 to 55 years. It is defined by the presence of a hypocellular spindle cell proliferation set in a myxoid background, often with mucin pooling. Lipoblasts tend to be small and often monovacuolated and to cluster around vessels or at the periphery of the lesion (review by Dei Tos, 2000). [from OMIM]

Clinical features

From HPO
Myxoid liposarcoma
MedGen UID:
104903
•Concept ID:
C0206634
•
Neoplastic Process
Myxoid liposarcoma is a soft tissue tumor that tends to occur in the limbs (especially the thigh) of patients ranging in age from 35 to 55 years. It is defined by the presence of a hypocellular spindle cell proliferation set in a myxoid background, often with mucin pooling. Lipoblasts tend to be small and often monovacuolated and to cluster around vessels or at the periphery of the lesion (review by Dei Tos, 2000).
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyxoid liposarcoma
Follow this link to review classifications for Myxoid liposarcoma in Orphanet.

Conditions with this feature

Myxoid liposarcoma
MedGen UID:
104903
•Concept ID:
C0206634
•
Neoplastic Process
Myxoid liposarcoma is a soft tissue tumor that tends to occur in the limbs (especially the thigh) of patients ranging in age from 35 to 55 years. It is defined by the presence of a hypocellular spindle cell proliferation set in a myxoid background, often with mucin pooling. Lipoblasts tend to be small and often monovacuolated and to cluster around vessels or at the periphery of the lesion (review by Dei Tos, 2000).
See: Condition Record
Myxoid liposarcoma

Professional guidelines

PubMed

Diagnosis and Treatment of Myxoid Liposarcomas: Histology Matters.
Abaricia S, Hirbe AC
Curr Treat Options Oncol 2018 Oct 25;19(12):64. doi: 10.1007/s11864-018-0590-5. PMID: 30362022
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article
The safety and efficacy of trabectedin for the treatment of liposarcoma or leiomyosarcoma.
Saponara M, Stacchiotti S, Gronchi A
Expert Rev Anticancer Ther 2016 May;16(5):473-84. Epub 2016 Apr 22 doi: 10.1080/14737140.2016.1174582. PMID: 27043847

Recent clinical studies

Etiology

Soft-tissue sarcoma in adolescents and young adults.
Kunisada T, Nakata E, Fujiwara T, Hosono A, Takihira S, Kondo H, Ozaki T
Int J Clin Oncol 2023 Jan;28(1):1-11. Epub 2022 Jan 27 doi: 10.1007/s10147-022-02119-7. PMID: 35084598
Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcoma: A Nonrandomized Controlled Trial.
Lansu J, Bovée JVMG, Braam P, van Boven H, Flucke U, Bonenkamp JJ, Miah AB, Zaidi SH, Thway K, Bruland ØS, Baldini EH, Jebsen NL, Scholten AN, van den Ende PLA, Krol ADG, Ubbels JF, van der Hage JA, van Werkhoven E, Klomp HM, van der Graaf WTA, van Coevorden F, Schrage Y, van Houdt WJ, Haas RL
JAMA Oncol 2021 Jan 1;7(1):e205865. Epub 2021 Jan 21 doi: 10.1001/jamaoncol.2020.5865. PMID: 33180100Free PMC Article
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Myxoid Emboli.
AbdullGaffar B, Waslewski K
Int J Surg Pathol 2018 Oct;26(7):609-616. Epub 2018 Apr 6 doi: 10.1177/1066896918768029. PMID: 29623727
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Diagnosis

Myxoid pleomorphic liposarcoma.
Fadaei S, Cordier F, Ferdinande L, Van Dorpe J, Creytens D
Histol Histopathol 2024 Sep;39(9):1101-1108. Epub 2024 Feb 26 doi: 10.14670/HH-18-724. PMID: 38450446
Myxoid Liposarcoma: How to Stage and Follow.
Ho TP
Curr Treat Options Oncol 2023 Apr;24(4):292-299. Epub 2023 Mar 3 doi: 10.1007/s11864-023-01064-5. PMID: 36867390
PRAME Expression in Cancer. A Systematic Immunohistochemical Study of >5800 Epithelial and Nonepithelial Tumors.
Kaczorowski M, Chłopek M, Kruczak A, Ryś J, Lasota J, Miettinen M
Am J Surg Pathol 2022 Nov 1;46(11):1467-1476. Epub 2022 Aug 16 doi: 10.1097/PAS.0000000000001944. PMID: 35973038Free PMC Article
Myxoid Emboli.
AbdullGaffar B, Waslewski K
Int J Surg Pathol 2018 Oct;26(7):609-616. Epub 2018 Apr 6 doi: 10.1177/1066896918768029. PMID: 29623727
Clinical and Molecular Spectrum of Liposarcoma.
Lee ATJ, Thway K, Huang PH, Jones RL
J Clin Oncol 2018 Jan 10;36(2):151-159. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.74.9598. PMID: 29220294Free PMC Article

Therapy

Afamitresgene autoleucel for advanced synovial sarcoma and myxoid round cell liposarcoma (SPEARHEAD-1): an international, open-label, phase 2 trial.
D'Angelo SP, Araujo DM, Abdul Razak AR, Agulnik M, Attia S, Blay JY, Carrasco Garcia I, Charlson JA, Choy E, Demetri GD, Druta M, Forcade E, Ganjoo KN, Glod J, Keedy VL, Le Cesne A, Liebner DA, Moreno V, Pollack SM, Schuetze SM, Schwartz GK, Strauss SJ, Tap WD, Thistlethwaite F, Valverde Morales CM, Wagner MJ, Wilky BA, McAlpine C, Hudson L, Navenot JM, Wang T, Bai J, Rafail S, Wang R, Sun A, Fernandes L, Van Winkle E, Elefant E, Lunt C, Norry E, Williams D, Biswas S, Van Tine BA
Lancet 2024 Apr 13;403(10435):1460-1471. Epub 2024 Mar 27 doi: 10.1016/S0140-6736(24)00319-2. PMID: 38554725Free PMC Article
Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcoma: A Nonrandomized Controlled Trial.
Lansu J, Bovée JVMG, Braam P, van Boven H, Flucke U, Bonenkamp JJ, Miah AB, Zaidi SH, Thway K, Bruland ØS, Baldini EH, Jebsen NL, Scholten AN, van den Ende PLA, Krol ADG, Ubbels JF, van der Hage JA, van Werkhoven E, Klomp HM, van der Graaf WTA, van Coevorden F, Schrage Y, van Houdt WJ, Haas RL
JAMA Oncol 2021 Jan 1;7(1):e205865. Epub 2021 Jan 21 doi: 10.1001/jamaoncol.2020.5865. PMID: 33180100Free PMC Article
Neoadjuvant Chemotherapy in High-Risk Soft Tissue Sarcomas: Final Results of a Randomized Trial From Italian (ISG), Spanish (GEIS), French (FSG), and Polish (PSG) Sarcoma Groups.
Gronchi A, Palmerini E, Quagliuolo V, Martin Broto J, Lopez Pousa A, Grignani G, Brunello A, Blay JY, Tendero O, Diaz Beveridge R, Ferraresi V, Lugowska I, Merlo DF, Fontana V, Marchesi E, Braglia L, Donati DM, Palassini E, Bianchi G, Marrari A, Morosi C, Stacchiotti S, Bagué S, Coindre JM, Dei Tos AP, Picci P, Bruzzi P, Casali PG
J Clin Oncol 2020 Jul 1;38(19):2178-2186. Epub 2020 May 18 doi: 10.1200/JCO.19.03289. PMID: 32421444
Diagnosis and Treatment of Myxoid Liposarcomas: Histology Matters.
Abaricia S, Hirbe AC
Curr Treat Options Oncol 2018 Oct 25;19(12):64. doi: 10.1007/s11864-018-0590-5. PMID: 30362022
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Prognosis

Myxoid pleomorphic liposarcoma.
Fadaei S, Cordier F, Ferdinande L, Van Dorpe J, Creytens D
Histol Histopathol 2024 Sep;39(9):1101-1108. Epub 2024 Feb 26 doi: 10.14670/HH-18-724. PMID: 38450446
Myxoid Liposarcoma: How to Stage and Follow.
Ho TP
Curr Treat Options Oncol 2023 Apr;24(4):292-299. Epub 2023 Mar 3 doi: 10.1007/s11864-023-01064-5. PMID: 36867390
Soft-tissue sarcoma in adolescents and young adults.
Kunisada T, Nakata E, Fujiwara T, Hosono A, Takihira S, Kondo H, Ozaki T
Int J Clin Oncol 2023 Jan;28(1):1-11. Epub 2022 Jan 27 doi: 10.1007/s10147-022-02119-7. PMID: 35084598
Molecular updates in adipocytic neoplasms(✰).
Demicco EG
Semin Diagn Pathol 2019 Mar;36(2):85-94. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.003. PMID: 30857767
Clinical and Molecular Spectrum of Liposarcoma.
Lee ATJ, Thway K, Huang PH, Jones RL
J Clin Oncol 2018 Jan 10;36(2):151-159. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.74.9598. PMID: 29220294Free PMC Article

Clinical prediction guides

Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcoma: A Nonrandomized Controlled Trial.
Lansu J, Bovée JVMG, Braam P, van Boven H, Flucke U, Bonenkamp JJ, Miah AB, Zaidi SH, Thway K, Bruland ØS, Baldini EH, Jebsen NL, Scholten AN, van den Ende PLA, Krol ADG, Ubbels JF, van der Hage JA, van Werkhoven E, Klomp HM, van der Graaf WTA, van Coevorden F, Schrage Y, van Houdt WJ, Haas RL
JAMA Oncol 2021 Jan 1;7(1):e205865. Epub 2021 Jan 21 doi: 10.1001/jamaoncol.2020.5865. PMID: 33180100Free PMC Article
Myxoid Liposarcoma With Skeletal Metastases: Pathophysiology and Imaging Characteristics.
Mujtaba B, Wang F, Taher A, Aslam R, Madewell JE, Nassar S
Curr Probl Diagn Radiol 2021 Jan-Feb;50(1):66-73. Epub 2019 Oct 30 doi: 10.1067/j.cpradiol.2019.10.008. PMID: 31813645
Neoadjuvant Chemotherapy in High-Risk Soft Tissue Sarcomas: Final Results of a Randomized Trial From Italian (ISG), Spanish (GEIS), French (FSG), and Polish (PSG) Sarcoma Groups.
Gronchi A, Palmerini E, Quagliuolo V, Martin Broto J, Lopez Pousa A, Grignani G, Brunello A, Blay JY, Tendero O, Diaz Beveridge R, Ferraresi V, Lugowska I, Merlo DF, Fontana V, Marchesi E, Braglia L, Donati DM, Palassini E, Bianchi G, Marrari A, Morosi C, Stacchiotti S, Bagué S, Coindre JM, Dei Tos AP, Picci P, Bruzzi P, Casali PG
J Clin Oncol 2020 Jul 1;38(19):2178-2186. Epub 2020 May 18 doi: 10.1200/JCO.19.03289. PMID: 32421444
Pharmacological therapies for Liposarcoma.
Saponara M, Stacchiotti S, Gronchi A
Expert Rev Clin Pharmacol 2017 Apr;10(4):361-377. Epub 2017 Feb 13 doi: 10.1080/17512433.2017.1289086. PMID: 28135854
The safety and efficacy of trabectedin for the treatment of liposarcoma or leiomyosarcoma.
Saponara M, Stacchiotti S, Gronchi A
Expert Rev Anticancer Ther 2016 May;16(5):473-84. Epub 2016 Apr 22 doi: 10.1080/14737140.2016.1174582. PMID: 27043847

Recent systematic reviews

Optimal treatment strategy for paratesticular liposarcoma: retrospective analysis of 265 reported cases.
Kamitani R, Matsumoto K, Takeda T, Mizuno R, Oya M
Int J Clin Oncol 2020 Dec;25(12):2099-2106. Epub 2020 Jul 26 doi: 10.1007/s10147-020-01753-3. PMID: 32715355

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...