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Elevated urinary xanthurenic acid level

MedGen UID:
1052485
•Concept ID:
CN376630
•
Finding
HPO: HP:6000121

Definition

The amount of xanthurenic acid in the urine, normalized for urine concentration, is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated urinary xanthurenic acid level

Conditions with this feature

Hydroxykynureninuria
MedGen UID:
78681
•Concept ID:
C0268474
•
Disease or Syndrome
Hydroxykynureninuria, also known as xanthurenicaciduria, is an autosomal recessive condition characterized by high urinary excretion of kynurenine (KYN), xanthurenic acid (XA) and 3-hydroxykynurenine (3-OHKYN), with no detectable anthranilic acid (AA) or 3-hydroxyanthranilic acid (3-OHAA) (Christensen et al., 2007).
See: Condition Record
Hydroxykynureninuria

Professional guidelines

PubMed

Investigations on the nutritional status of advanced breast cancer patients. The influence of long-term treatment with megestrol acetate or tamoxifen.
Schrijver J, Alexieva-Figusch J, van Breederode N, van Gilse HA
Nutr Cancer 1987;10(4):231-45. doi: 10.1080/01635588709513961. PMID: 3432093

Recent clinical studies

Etiology

Longitudinal relationship of amino acids and indole metabolites with long-term body mass index and cardiometabolic risk markers in young individuals.
Oluwagbemigun K, Anesi A, Ulaszewska M, Clarke G, Alexy U, Schmid M, Roden M, Herder C, Mattivi F, Nöthlings U
Sci Rep 2020 Apr 14;10(1):6399. doi: 10.1038/s41598-020-63313-z. PMID: 32286421Free PMC Article
Investigations on the nutritional status of advanced breast cancer patients. The influence of long-term treatment with megestrol acetate or tamoxifen.
Schrijver J, Alexieva-Figusch J, van Breederode N, van Gilse HA
Nutr Cancer 1987;10(4):231-45. doi: 10.1080/01635588709513961. PMID: 3432093
Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
Rose DP, Leklem JE, Brown RR, Linkswiler HM
Am J Clin Nutr 1975 Aug;28(8):872-8. doi: 10.1093/ajcn/28.8.872. PMID: 1146747
Relationship between levels of blood lipids, vitamins C, A, and E, serum copper compounds, and urinary excretions of tryptophan metabolites in women taking oral contraceptive therapy.
Horwitt MK, Harvey CC, Dahm CH Jr
Am J Clin Nutr 1975 Apr;28(4):403-12. doi: 10.1093/ajcn/28.4.403. PMID: 1119436

Therapy

Investigations on the nutritional status of advanced breast cancer patients. The influence of long-term treatment with megestrol acetate or tamoxifen.
Schrijver J, Alexieva-Figusch J, van Breederode N, van Gilse HA
Nutr Cancer 1987;10(4):231-45. doi: 10.1080/01635588709513961. PMID: 3432093
Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
Adams PW, Wynn V, Folkard J, Seed M
Lancet 1976 Apr 10;1(7963):759-64. doi: 10.1016/s0140-6736(76)91607-x. PMID: 56585
Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
Rose DP, Leklem JE, Brown RR, Linkswiler HM
Am J Clin Nutr 1975 Aug;28(8):872-8. doi: 10.1093/ajcn/28.8.872. PMID: 1146747
Oral contraceptives and tryptophan metabolism: effects of oestrogen in low dose combined with a progestagen and of a low-dose progestagen (megestrol acetate) given alone.
Rose DP, Adams PW
J Clin Pathol 1972 Mar;25(3):252-8. doi: 10.1136/jcp.25.3.252. PMID: 5018716Free PMC Article

Clinical prediction guides

Longitudinal relationship of amino acids and indole metabolites with long-term body mass index and cardiometabolic risk markers in young individuals.
Oluwagbemigun K, Anesi A, Ulaszewska M, Clarke G, Alexy U, Schmid M, Roden M, Herder C, Mattivi F, Nöthlings U
Sci Rep 2020 Apr 14;10(1):6399. doi: 10.1038/s41598-020-63313-z. PMID: 32286421Free PMC Article
Investigations on the nutritional status of advanced breast cancer patients. The influence of long-term treatment with megestrol acetate or tamoxifen.
Schrijver J, Alexieva-Figusch J, van Breederode N, van Gilse HA
Nutr Cancer 1987;10(4):231-45. doi: 10.1080/01635588709513961. PMID: 3432093
Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
Adams PW, Wynn V, Folkard J, Seed M
Lancet 1976 Apr 10;1(7963):759-64. doi: 10.1016/s0140-6736(76)91607-x. PMID: 56585
Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
Rose DP, Leklem JE, Brown RR, Linkswiler HM
Am J Clin Nutr 1975 Aug;28(8):872-8. doi: 10.1093/ajcn/28.8.872. PMID: 1146747

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