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Abnormal urine metabolite level

MedGen UID:
1785188
•Concept ID:
C5539535
•
Finding
HPO: HP:0033354

Definition

Any deviation from the normal amount of a metabolite in urine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal urine metabolite level

Professional guidelines

PubMed

Urinary antibiotic exposure across pregnancy from Chinese pregnant women and health risk assessment: Repeated measures analysis.
Geng M, Liu K, Huang K, Zhu Y, Ding P, Zhang J, Wang B, Liu W, Han Y, Gao H, Wang S, Chen G, Wu X, Tao F
Environ Int 2020 Dec;145:106164. Epub 2020 Oct 6 doi: 10.1016/j.envint.2020.106164. PMID: 33035894
Cerebral creatine deficiency syndromes: clinical aspects, treatment and pathophysiology.
Stockler S, Schutz PW, Salomons GS
Subcell Biochem 2007;46:149-66. doi: 10.1007/978-1-4020-6486-9_8. PMID: 18652076
Catecholamine phenotyping: clues to the diagnosis, treatment, and pathophysiology of neurogenetic disorders.
Goldstein DS, Lenders JW, Kaler SG, Eisenhofer G
J Neurochem 1996 Nov;67(5):1781-90. doi: 10.1046/j.1471-4159.1996.67051781.x. PMID: 8863481

Recent clinical studies

Etiology

Association between nocturnal light exposure and melatonin in humans: a meta-analysis.
Lu J, Zou R, Yang Y, Bai X, Wei W, Ding R, Hua X
Environ Sci Pollut Res Int 2024 Jan;31(3):3425-3434. Epub 2023 Dec 20 doi: 10.1007/s11356-023-31502-8. PMID: 38123771
Organophosphate Flame Retardants in Pregnant Women: Sources, Occurrence, and Potential Risks to Pregnancy Outcomes.
Li Y, Wang X, Zhu Q, Xu Y, Fu Q, Wang T, Liao C, Jiang G
Environ Sci Technol 2023 May 9;57(18):7109-7128. Epub 2023 Apr 20 doi: 10.1021/acs.est.2c06503. PMID: 37079500
Sex Hormone Metabolism and Threatened Abortion.
Xu Q, Chen J, Wei Z, Brandon TR, Zava DT, Shi YE, Cao Y
Med Sci Monit 2017 Oct 23;23:5041-5048. doi: 10.12659/msm.904500. PMID: 29056745Free PMC Article
Cryptorchidism and pesticides: Is there a connection?
Fratrić I, Varga J, Vukmirović S, Sudji J, Živković D
J Pediatr Surg 2017 Jul;52(7):1166-1168. Epub 2016 Dec 7 doi: 10.1016/j.jpedsurg.2016.11.048. PMID: 27956069
Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children.
Zhang C, Yin A, Li H, Wang R, Wu G, Shen J, Zhang M, Wang L, Hou Y, Ouyang H, Zhang Y, Zheng Y, Wang J, Lv X, Wang Y, Zhang F, Zeng B, Li W, Yan F, Zhao Y, Pang X, Zhang X, Fu H, Chen F, Zhao N, Hamaker BR, Bridgewater LC, Weinkove D, Clement K, Dore J, Holmes E, Xiao H, Zhao G, Yang S, Bork P, Nicholson JK, Wei H, Tang H, Zhang X, Zhao L
EBioMedicine 2015 Aug;2(8):968-84. Epub 2015 Jul 10 doi: 10.1016/j.ebiom.2015.07.007. PMID: 26425705Free PMC Article

Diagnosis

Urinary Metabolite Profile Predicting the Progression of CKD.
Kim Y, Lee J, Kang MS, Song J, Kim SG, Cho S, Huh H, Lee S, Park S, Jo HA, Yang SH, Paek JH, Park WY, Han SS, Lee H, Lee JP, Joo KW, Lim CS, Hwang GS, Kim DK
Kidney360 2023 Aug 1;4(8):1048-1057. Epub 2023 Jun 9 doi: 10.34067/KID.0000000000000158. PMID: 37291728Free PMC Article
Laboratory and metabolic investigations.
Morava E, Oglesbee D
Handb Clin Neurol 2023;194:167-172. doi: 10.1016/B978-0-12-821751-1.00012-9. PMID: 36813311
Apparent mineralocorticoid excess.
Funder JW
J Steroid Biochem Mol Biol 2017 Jan;165(Pt A):151-153. Epub 2016 Mar 5 doi: 10.1016/j.jsbmb.2016.03.010. PMID: 26956190
Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma.
Chen T, Xie G, Wang X, Fan J, Qiu Y, Zheng X, Qi X, Cao Y, Su M, Wang X, Xu LX, Yen Y, Liu P, Jia W
Mol Cell Proteomics 2011 Jul;10(7):M110.004945. Epub 2011 Apr 25 doi: 10.1074/mcp.M110.004945. PMID: 21518826Free PMC Article
Apparent mineralocorticoid excess.
Funder JW
Endocrinol Metab Clin North Am 1995 Sep;24(3):613-21. PMID: 8575412

Therapy

Maternal environmental, occupational, and urinary metabolite levels of benzene compounds and their association with congenital heart diseases in offspring: a case‒control study in China.
Wang M, Li L, Kang H, Xu H, Huang Q, Li N, Deng Y, Yu P, Liu Z
Environ Sci Pollut Res Int 2023 May;30(24):66021-66032. Epub 2023 Apr 25 doi: 10.1007/s11356-023-27015-z. PMID: 37095212Free PMC Article
Fibroblast Growth Factor 23 and Klotho in AKI.
Christov M, Neyra JA, Gupta S, Leaf DE
Semin Nephrol 2019 Jan;39(1):57-75. doi: 10.1016/j.semnephrol.2018.10.005. PMID: 30606408
Cryptorchidism and pesticides: Is there a connection?
Fratrić I, Varga J, Vukmirović S, Sudji J, Živković D
J Pediatr Surg 2017 Jul;52(7):1166-1168. Epub 2016 Dec 7 doi: 10.1016/j.jpedsurg.2016.11.048. PMID: 27956069
Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children.
Zhang C, Yin A, Li H, Wang R, Wu G, Shen J, Zhang M, Wang L, Hou Y, Ouyang H, Zhang Y, Zheng Y, Wang J, Lv X, Wang Y, Zhang F, Zeng B, Li W, Yan F, Zhao Y, Pang X, Zhang X, Fu H, Chen F, Zhao N, Hamaker BR, Bridgewater LC, Weinkove D, Clement K, Dore J, Holmes E, Xiao H, Zhao G, Yang S, Bork P, Nicholson JK, Wei H, Tang H, Zhang X, Zhao L
EBioMedicine 2015 Aug;2(8):968-84. Epub 2015 Jul 10 doi: 10.1016/j.ebiom.2015.07.007. PMID: 26425705Free PMC Article
The physiology and pharmacology of melatonin in humans.
Geoffriau M, Brun J, Chazot G, Claustrat B
Horm Res 1998;49(3-4):136-41. doi: 10.1159/000023160. PMID: 9550114

Prognosis

Urinary Metabolite Profile Predicting the Progression of CKD.
Kim Y, Lee J, Kang MS, Song J, Kim SG, Cho S, Huh H, Lee S, Park S, Jo HA, Yang SH, Paek JH, Park WY, Han SS, Lee H, Lee JP, Joo KW, Lim CS, Hwang GS, Kim DK
Kidney360 2023 Aug 1;4(8):1048-1057. Epub 2023 Jun 9 doi: 10.34067/KID.0000000000000158. PMID: 37291728Free PMC Article
Organophosphate Flame Retardants in Pregnant Women: Sources, Occurrence, and Potential Risks to Pregnancy Outcomes.
Li Y, Wang X, Zhu Q, Xu Y, Fu Q, Wang T, Liao C, Jiang G
Environ Sci Technol 2023 May 9;57(18):7109-7128. Epub 2023 Apr 20 doi: 10.1021/acs.est.2c06503. PMID: 37079500
Fibroblast Growth Factor 23 and Klotho in AKI.
Christov M, Neyra JA, Gupta S, Leaf DE
Semin Nephrol 2019 Jan;39(1):57-75. doi: 10.1016/j.semnephrol.2018.10.005. PMID: 30606408
Cryptorchidism and pesticides: Is there a connection?
Fratrić I, Varga J, Vukmirović S, Sudji J, Živković D
J Pediatr Surg 2017 Jul;52(7):1166-1168. Epub 2016 Dec 7 doi: 10.1016/j.jpedsurg.2016.11.048. PMID: 27956069
Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy.
Reyes H, Sjövall J
Ann Med 2000 Mar;32(2):94-106. doi: 10.3109/07853890009011758. PMID: 10766400

Clinical prediction guides

Urinary Metabolite Profile Predicting the Progression of CKD.
Kim Y, Lee J, Kang MS, Song J, Kim SG, Cho S, Huh H, Lee S, Park S, Jo HA, Yang SH, Paek JH, Park WY, Han SS, Lee H, Lee JP, Joo KW, Lim CS, Hwang GS, Kim DK
Kidney360 2023 Aug 1;4(8):1048-1057. Epub 2023 Jun 9 doi: 10.34067/KID.0000000000000158. PMID: 37291728Free PMC Article
Organophosphate Flame Retardants in Pregnant Women: Sources, Occurrence, and Potential Risks to Pregnancy Outcomes.
Li Y, Wang X, Zhu Q, Xu Y, Fu Q, Wang T, Liao C, Jiang G
Environ Sci Technol 2023 May 9;57(18):7109-7128. Epub 2023 Apr 20 doi: 10.1021/acs.est.2c06503. PMID: 37079500
Laboratory and metabolic investigations.
Morava E, Oglesbee D
Handb Clin Neurol 2023;194:167-172. doi: 10.1016/B978-0-12-821751-1.00012-9. PMID: 36813311
Fibroblast Growth Factor 23 and Klotho in AKI.
Christov M, Neyra JA, Gupta S, Leaf DE
Semin Nephrol 2019 Jan;39(1):57-75. doi: 10.1016/j.semnephrol.2018.10.005. PMID: 30606408
Mitochondrial dysfunction in Autism Spectrum Disorder: clinical features and perspectives.
Hollis F, Kanellopoulos AK, Bagni C
Curr Opin Neurobiol 2017 Aug;45:178-187. Epub 2017 Jun 16 doi: 10.1016/j.conb.2017.05.018. PMID: 28628841

Recent systematic reviews

Paediatric obesity: a systematic review and pathway mapping of metabolic alterations underlying early disease processes.
De Spiegeleer M, De Paepe E, Van Meulebroek L, Gies I, De Schepper J, Vanhaecke L
Mol Med 2021 Nov 6;27(1):145. doi: 10.1186/s10020-021-00394-0. PMID: 34742239Free PMC Article
Association between prenatal phthalate exposure and gestational metabolic syndrome parameters: a systematic review of epidemiological studies.
Gao H, Zhang C, Tao FB
Environ Sci Pollut Res Int 2021 May;28(17):20921-20938. Epub 2021 Mar 5 doi: 10.1007/s11356-021-13120-4. PMID: 33674970
Metabolomic Analysis in Inflammatory Bowel Disease: A Systematic Review.
Gallagher K, Catesson A, Griffin JL, Holmes E, Williams HRT
J Crohns Colitis 2021 May 4;15(5):813-826. doi: 10.1093/ecco-jcc/jjaa227. PMID: 33175138

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