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Abnormal urinary bile acid level

MedGen UID:
1054842
•Concept ID:
CN377355
•
Finding
HPO: HP:6000524

Definition

The amount of bile acids in the urine, normalized for urine concentration, is outside the limits of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal urinary bile acid level

Professional guidelines

PubMed

Serum bile acids associate with liver volume in polycystic liver disease and decrease upon treatment with lanreotide.
Dekker SEI, Bierau J, Giera M, Blomberg N, Drenth JPH, Mayboroda OA, de Fijter JW, Soonawala D; DIPAK Consortium
Eur J Clin Invest 2024 Apr;54(4):e14147. Epub 2023 Dec 9 doi: 10.1111/eci.14147. PMID: 38071418

Recent clinical studies

Etiology

Metabolomic profiling reveals the step-wise alteration of bile acid metabolism in patients with diabetic kidney disease.
Zhang Q, Lu L, Wang J, Lu M, Liu D, Zhou C, Liu Z
Nutr Diabetes 2024 Oct 9;14(1):85. doi: 10.1038/s41387-024-00315-0. PMID: 39384774Free PMC Article
Metabolomic study of the protective effect of Gandi capsule for diabetic nephropathy.
Liu Y, Chen X, Liu Y, Chen T, Zhang Q, Zhang H, Zhu Z, Chai Y, Zhang J
Chem Biol Interact 2019 Dec 1;314:108815. Epub 2019 Sep 6 doi: 10.1016/j.cbi.2019.108815. PMID: 31499054
Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy.
Reyes H, Sjövall J
Ann Med 2000 Mar;32(2):94-106. doi: 10.3109/07853890009011758. PMID: 10766400
The hyperlipidemia of the nephrotic syndrome.
Appel GB, Valeri A, Appel AS, Blum C
Am J Med 1989 Nov;87(5N):45N-50N. PMID: 2486547
Bile salt and micellar fat concentration in proximal small bowel contents of ileectomy patients.
Van Deest BW, Fordtran JS, Morawski SG, Wilson JD
J Clin Invest 1968 Jun;47(6):1314-24. doi: 10.1172/JCI105823. PMID: 5653211Free PMC Article

Diagnosis

Correlation of liver and kidney indicators with foetal vital organ function.
Zhou J, Chen Y, Ma L, Zhou C, Zhe R
J Obstet Gynaecol 2022 Oct;42(7):2912-2916. Epub 2022 Aug 23 doi: 10.1080/01443615.2022.2112939. PMID: 35998258
Open-label Phase 3 Continuation Study of Cholic Acid in Patients With Inborn Errors of Bile Acid Synthesis.
Heubi JE, Setchell KDR
J Pediatr Gastroenterol Nutr 2020 Apr;70(4):423-429. doi: 10.1097/MPG.0000000000002618. PMID: 31899729
Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma.
Chen T, Xie G, Wang X, Fan J, Qiu Y, Zheng X, Qi X, Cao Y, Su M, Wang X, Xu LX, Yen Y, Liu P, Jia W
Mol Cell Proteomics 2011 Jul;10(7):M110.004945. Epub 2011 Apr 25 doi: 10.1074/mcp.M110.004945. PMID: 21518826Free PMC Article
Urinary sulfated bile acids: a new simple urine test for cholestasis in infants and children.
Obatake M, Muraji T, Satoh S, Nishijima E, Tsugawa C
J Pediatr Surg 2002 Dec;37(12):1707-8. doi: 10.1053/jpsu.2002.36701. PMID: 12483636
Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy.
Reyes H, Sjövall J
Ann Med 2000 Mar;32(2):94-106. doi: 10.3109/07853890009011758. PMID: 10766400

Therapy

Serum bile acids associate with liver volume in polycystic liver disease and decrease upon treatment with lanreotide.
Dekker SEI, Bierau J, Giera M, Blomberg N, Drenth JPH, Mayboroda OA, de Fijter JW, Soonawala D; DIPAK Consortium
Eur J Clin Invest 2024 Apr;54(4):e14147. Epub 2023 Dec 9 doi: 10.1111/eci.14147. PMID: 38071418
Open-label Phase 3 Continuation Study of Cholic Acid in Patients With Inborn Errors of Bile Acid Synthesis.
Heubi JE, Setchell KDR
J Pediatr Gastroenterol Nutr 2020 Apr;70(4):423-429. doi: 10.1097/MPG.0000000000002618. PMID: 31899729
Metabolomic study of the protective effect of Gandi capsule for diabetic nephropathy.
Liu Y, Chen X, Liu Y, Chen T, Zhang Q, Zhang H, Zhu Z, Chai Y, Zhang J
Chem Biol Interact 2019 Dec 1;314:108815. Epub 2019 Sep 6 doi: 10.1016/j.cbi.2019.108815. PMID: 31499054
Urinary sulfated bile acids: a new simple urine test for cholestasis in infants and children.
Obatake M, Muraji T, Satoh S, Nishijima E, Tsugawa C
J Pediatr Surg 2002 Dec;37(12):1707-8. doi: 10.1053/jpsu.2002.36701. PMID: 12483636
Clinical pharmacology of antibiotics and other drugs in cystic fibrosis.
Prandota J
Drugs 1988 May;35(5):542-78. doi: 10.2165/00003495-198835050-00004. PMID: 3293970

Prognosis

Correlation of liver and kidney indicators with foetal vital organ function.
Zhou J, Chen Y, Ma L, Zhou C, Zhe R
J Obstet Gynaecol 2022 Oct;42(7):2912-2916. Epub 2022 Aug 23 doi: 10.1080/01443615.2022.2112939. PMID: 35998258
Toxicity of Amphotericin B Deoxycholate-Based Induction Therapy in Patients with HIV-Associated Cryptococcal Meningitis.
Bicanic T, Bottomley C, Loyse A, Brouwer AE, Muzoora C, Taseera K, Jackson A, Phulusa J, Hosseinipour MC, van der Horst C, Limmathurotsakul D, White NJ, Wilson D, Wood R, Meintjes G, Harrison TS, Jarvis JN
Antimicrob Agents Chemother 2015 Dec;59(12):7224-31. Epub 2015 Sep 8 doi: 10.1128/AAC.01698-15. PMID: 26349818Free PMC Article
Efficacy of urinary sulfated bile acids for diagnosis of bacterial cholangitis in biliary atresia.
Shinohara T, Muraji T, Tsugawa C, Nishijima E, Satoh S, Takamizawa S
Pediatr Surg Int 2005 Sep;21(9):701-4. Epub 2005 Oct 20 doi: 10.1007/s00383-005-1493-7. PMID: 16096796
Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy.
Reyes H, Sjövall J
Ann Med 2000 Mar;32(2):94-106. doi: 10.3109/07853890009011758. PMID: 10766400
Wilson's disease: a new gene and an animal model for an old disease.
Cuthbert JA
J Investig Med 1995 Aug;43(4):323-36. PMID: 7552582

Clinical prediction guides

Correlation of liver and kidney indicators with foetal vital organ function.
Zhou J, Chen Y, Ma L, Zhou C, Zhe R
J Obstet Gynaecol 2022 Oct;42(7):2912-2916. Epub 2022 Aug 23 doi: 10.1080/01443615.2022.2112939. PMID: 35998258
Open-label Phase 3 Continuation Study of Cholic Acid in Patients With Inborn Errors of Bile Acid Synthesis.
Heubi JE, Setchell KDR
J Pediatr Gastroenterol Nutr 2020 Apr;70(4):423-429. doi: 10.1097/MPG.0000000000002618. PMID: 31899729
Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy.
Reyes H, Sjövall J
Ann Med 2000 Mar;32(2):94-106. doi: 10.3109/07853890009011758. PMID: 10766400
Wilson's disease: a new gene and an animal model for an old disease.
Cuthbert JA
J Investig Med 1995 Aug;43(4):323-36. PMID: 7552582
Clinical pharmacology of antibiotics and other drugs in cystic fibrosis.
Prandota J
Drugs 1988 May;35(5):542-78. doi: 10.2165/00003495-198835050-00004. PMID: 3293970

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