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Panophthalmitis

MedGen UID:
10561
•Concept ID:
C0030332
•
Disease or Syndrome
Synonym: Panophthalmitides
SNOMED CT: Panophthalmitis (33382000)
 
Monarch Initiative: MONDO:0006884

Definition

Acute suppurative inflammation of the inner eye with necrosis of the sclera (and sometimes the cornea) and extension of the inflammation into the orbit. Pain may be severe and the globe may rupture. In endophthalmitis the globe does not rupture. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPanophthalmitis

Professional guidelines

PubMed

Microbial Keratitis in Thyroid Eye Disease: Clinical Features, Microbiological Profile, and Treatment Outcome.
Naik MN, Vasanthapuram VH, Joseph J, Murthy SI
Ophthalmic Plast Reconstr Surg 2019 Nov/Dec;35(6):543-548. doi: 10.1097/IOP.0000000000001361. PMID: 30844912
Demograhic pattern, clinical features and treatment outcome of patients with infective keratitis in the eastern region of Nepal.
Lavaju P, Arya SK, Khanal B, Amatya R, Patel S
Nepal J Ophthalmol 2009 Jul-Dec;1(2):101-6. doi: 10.3126/nepjoph.v1i2.3683. PMID: 21141001

Recent clinical studies

Etiology

Tuberculous Scleritis and Multidrug Resistance.
Agarwal M, Patnaik G, Agarwal S, Iyer G, Anand AR, Ar G, Biswas J, Zierhut M
Ocul Immunol Inflamm 2022 May 19;30(4):915-924. Epub 2021 Jan 8 doi: 10.1080/09273948.2020.1853176. PMID: 33416427
Ocular Tuberculosis in HIV-infected Individuals.
Mehta S, Peters RP, Smit DP, Gupta V
Ocul Immunol Inflamm 2020 Nov 16;28(8):1251-1258. Epub 2020 Aug 18 doi: 10.1080/09273948.2020.1776882. PMID: 32809898
Endophthalmitis Progressing to Panophthalmitis: Clinical Features, Demographic Profile, and Factors Predicting Outcome.
Pappuru RR, Dave VP, Pathengay A, Gangakhedkar S, Sharma S, Narayanan R, Tyagi M, Grzybowski A, Das T
Semin Ophthalmol 2018;33(5):671-674. Epub 2017 Dec 19 doi: 10.1080/08820538.2017.1416411. PMID: 29256717
Triple infection keratitis.
Ray M, Nigel LC, Tan AM
Eye Contact Lens 2014 May;40(3):123-6. doi: 10.1097/ICL.0000000000000022. PMID: 24681610
Clostridium perfringens Keratitis Leading to Blinding Panophthalmitis.
Hsu HY, Lee SF, Hartstein ME, Harocopos GJ
Cornea 2008 Dec;27(10):1200-3. doi: 10.1097/ICO.0b013e318180e5a1. PMID: 19034143

Diagnosis

Tuberculous Scleritis and Multidrug Resistance.
Agarwal M, Patnaik G, Agarwal S, Iyer G, Anand AR, Ar G, Biswas J, Zierhut M
Ocul Immunol Inflamm 2022 May 19;30(4):915-924. Epub 2021 Jan 8 doi: 10.1080/09273948.2020.1853176. PMID: 33416427
Ocular Syphilis Causing Panophthalmitis.
Mathews B, George R, Ulrich JN
Ophthalmic Plast Reconstr Surg 2021 Mar-Apr 01;37(2):e69-e71. doi: 10.1097/IOP.0000000000001780. PMID: 32732543
Ocular Tuberculosis in HIV-infected Individuals.
Mehta S, Peters RP, Smit DP, Gupta V
Ocul Immunol Inflamm 2020 Nov 16;28(8):1251-1258. Epub 2020 Aug 18 doi: 10.1080/09273948.2020.1776882. PMID: 32809898
HIV and cannot see.
Prospero Ponce CM, Al Zubidi N, Beaver HA, Lee AG, Huey DA, Chavis PS
Surv Ophthalmol 2014 Jul-Aug;59(4):468-73. Epub 2013 Oct 17 doi: 10.1016/j.survophthal.2013.10.003. PMID: 24856819
Trichophyton fungal keratitis.
Mohammad A, Al-Rajhi A, Wagoner MD
Cornea 2006 Jan;25(1):118-22. doi: 10.1097/01.ico.0000164834.77291.51. PMID: 16331054

Therapy

Recent advancements in nanotechnology-based bacteriophage delivery strategies against bacterial ocular infections.
Patil R, Dehari D, Chaudhuri A, Kumar DN, Kumar D, Singh S, Nath G, Agrawal AK
Microbiol Res 2023 Aug;273:127413. Epub 2023 May 18 doi: 10.1016/j.micres.2023.127413. PMID: 37216845
Tuberculous Scleritis and Multidrug Resistance.
Agarwal M, Patnaik G, Agarwal S, Iyer G, Anand AR, Ar G, Biswas J, Zierhut M
Ocul Immunol Inflamm 2022 May 19;30(4):915-924. Epub 2021 Jan 8 doi: 10.1080/09273948.2020.1853176. PMID: 33416427
Ocular Tuberculosis in HIV-infected Individuals.
Mehta S, Peters RP, Smit DP, Gupta V
Ocul Immunol Inflamm 2020 Nov 16;28(8):1251-1258. Epub 2020 Aug 18 doi: 10.1080/09273948.2020.1776882. PMID: 32809898
Trichophyton fungal keratitis.
Mohammad A, Al-Rajhi A, Wagoner MD
Cornea 2006 Jan;25(1):118-22. doi: 10.1097/01.ico.0000164834.77291.51. PMID: 16331054
Tuberculous panophthalmitis.
McMoli TE, Mordi VP, Grange A, Abiose A
J Pediatr Ophthalmol Strabismus 1978 Nov-Dec;15(6):383-5. doi: 10.3928/0191-3913-19781101-12. PMID: 739370

Prognosis

Fulminant Sphingomonas paucimobilis keratitis: case study and review of literature.
Agarwal R, Gagrani M, Mahajan A, Sharma N
BMJ Case Rep 2019 Dec 3;12(12) doi: 10.1136/bcr-2019-231642. PMID: 31801779Free PMC Article
Endophthalmitis Progressing to Panophthalmitis: Clinical Features, Demographic Profile, and Factors Predicting Outcome.
Pappuru RR, Dave VP, Pathengay A, Gangakhedkar S, Sharma S, Narayanan R, Tyagi M, Grzybowski A, Das T
Semin Ophthalmol 2018;33(5):671-674. Epub 2017 Dec 19 doi: 10.1080/08820538.2017.1416411. PMID: 29256717
HIV and cannot see.
Prospero Ponce CM, Al Zubidi N, Beaver HA, Lee AG, Huey DA, Chavis PS
Surv Ophthalmol 2014 Jul-Aug;59(4):468-73. Epub 2013 Oct 17 doi: 10.1016/j.survophthal.2013.10.003. PMID: 24856819
Triple infection keratitis.
Ray M, Nigel LC, Tan AM
Eye Contact Lens 2014 May;40(3):123-6. doi: 10.1097/ICL.0000000000000022. PMID: 24681610
Bacterial endophthalmitis in neonates.
Lohrer R, Belohradsky BH
Eur J Pediatr 1987 Jul;146(4):354-9. doi: 10.1007/BF00444936. PMID: 3308466

Clinical prediction guides

Tuberculous Scleritis and Multidrug Resistance.
Agarwal M, Patnaik G, Agarwal S, Iyer G, Anand AR, Ar G, Biswas J, Zierhut M
Ocul Immunol Inflamm 2022 May 19;30(4):915-924. Epub 2021 Jan 8 doi: 10.1080/09273948.2020.1853176. PMID: 33416427
Aflibercept-Related Sterile Intraocular Inflammation Outcomes.
Greenberg JP, Belin P, Butler J, Feiler D, Mueller C, Tye A, Friedlander SM, Emerson GG, Ferrone PJ; Aflibercept Sterile Inflammation Research Group
Ophthalmol Retina 2019 Sep;3(9):753-759. Epub 2019 Apr 11 doi: 10.1016/j.oret.2019.04.006. PMID: 31153850
Endophthalmitis Progressing to Panophthalmitis: Clinical Features, Demographic Profile, and Factors Predicting Outcome.
Pappuru RR, Dave VP, Pathengay A, Gangakhedkar S, Sharma S, Narayanan R, Tyagi M, Grzybowski A, Das T
Semin Ophthalmol 2018;33(5):671-674. Epub 2017 Dec 19 doi: 10.1080/08820538.2017.1416411. PMID: 29256717
Panophthalmitis due to clostridium septicum.
Schickner DC, Yarkoni A, Langer P, Frohman L, Chen X, Folberg R, Del Priore LV
Am J Ophthalmol 2004 May;137(5):942-4. doi: 10.1016/j.ajo.2003.10.030. PMID: 15126166
Bacillus laterosporus endophthalmitis.
Yabbara KF, Juffali F, Matossian RM
Arch Ophthalmol 1977 Dec;95(12):2187-9. doi: 10.1001/archopht.1977.04450120093010. PMID: 303897

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