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Disorder of pharynx

MedGen UID:
10691
•Concept ID:
C0031345
•
Disease or Syndrome
Synonym: Disease of pharynx
SNOMED CT: Disorder of pharynx (75860007)
 
Monarch Initiative: MONDO:0020592

Definition

A non-neoplastic or neoplastic disorder that affects the pharynx. Representative examples include pharyngitis and carcinoma. [from NCI]

Professional guidelines

PubMed

HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management.
Lechner M, Liu J, Masterson L, Fenton TR
Nat Rev Clin Oncol 2022 May;19(5):306-327. Epub 2022 Feb 1 doi: 10.1038/s41571-022-00603-7. PMID: 35105976Free PMC Article
Diagnostic Methods, Clinical Guidelines, and Antibiotic Treatment for Group A Streptococcal Pharyngitis: A Narrative Review.
Mustafa Z, Ghaffari M
Front Cell Infect Microbiol 2020;10:563627. Epub 2020 Oct 15 doi: 10.3389/fcimb.2020.563627. PMID: 33178623Free PMC Article
Pharyngitis: Approach to diagnosis and treatment.
Sykes EA, Wu V, Beyea MM, Simpson MTW, Beyea JA
Can Fam Physician 2020 Apr;66(4):251-257. PMID: 32273409Free PMC Article

Recent clinical studies

Etiology

Risk factor of pharyngocutaneous fistula.
Kedous S, Turki S, Elhedhili F, Dhambri S, Jbeli S, Touati S, Gritli S
Tunis Med 2019 Mar;97(3):491-499. PMID: 31729725
Reconstruction after salvage laryngectomy.
Yeh DH, Sahovaler A, Fung K
Oral Oncol 2017 Dec;75:22-27. Epub 2017 Oct 21 doi: 10.1016/j.oraloncology.2017.10.009. PMID: 29224818
Relation Between the Type of Hospitals and the Decision of Adenotonsillectomy Indication.
Kocyigit M, G Ortekin S, Cakabay T, Ustun Bezgin S, Serin Keskinege B
J Craniofac Surg 2017 Jun;28(4):e377-e381. doi: 10.1097/SCS.0000000000003714. PMID: 28590395
Pharyngocutaneous fistula.
Mäkitie AA, Irish J, Gullane PJ
Curr Opin Otolaryngol Head Neck Surg 2003 Apr;11(2):78-84. doi: 10.1097/00020840-200304000-00003. PMID: 14515083
Discoordinate pharyngolaryngomalacia.
Froehlich P, Seid AB, Denoyelle F, Pransky SM, Kearns DB, Garabedian EN, Morgon A
Int J Pediatr Otorhinolaryngol 1997 Feb 14;39(1):9-18. doi: 10.1016/S0165-5876(96)01454-1. PMID: 9051435

Diagnosis

The Underestimated Role of Mast Cells in the Pathogenesis of Rhinopathies.
Gelardi M, Giancaspro R, Cassano M, Ribatti D
Int Arch Allergy Immunol 2022;183(2):153-159. Epub 2021 Sep 22 doi: 10.1159/000518924. PMID: 34551414
Pharyngeal rhinosporidiosis.
Chandran A, Sakthivel P, Kumar R, Rajeshwari M
BMJ Case Rep 2020 Jun 17;13(6) doi: 10.1136/bcr-2020-236404. PMID: 32554456Free PMC Article
Relation Between the Type of Hospitals and the Decision of Adenotonsillectomy Indication.
Kocyigit M, G Ortekin S, Cakabay T, Ustun Bezgin S, Serin Keskinege B
J Craniofac Surg 2017 Jun;28(4):e377-e381. doi: 10.1097/SCS.0000000000003714. PMID: 28590395
Pharyngocutaneous fistula.
Mäkitie AA, Irish J, Gullane PJ
Curr Opin Otolaryngol Head Neck Surg 2003 Apr;11(2):78-84. doi: 10.1097/00020840-200304000-00003. PMID: 14515083
Retropharyngeal abscess.
Coulthard M, Isaacs D
Arch Dis Child 1991 Oct;66(10):1227-30. doi: 10.1136/adc.66.10.1227. PMID: 1953008Free PMC Article

Therapy

Role of Exosomes in Pharyngucutaneous Fistula After Total Laryngectomy.
Chen L, Wang M, Zhong Z, Liu B, Zhang W, Zhu B, Jiao C, Yu C, Guan B
Int J Nanomedicine 2022;17:4119-4135. Epub 2022 Sep 12 doi: 10.2147/IJN.S372042. PMID: 36118178Free PMC Article
Reporting Quality of Randomized, Controlled Trials Evaluating Combined Chemoradiotherapy in Nasopharyngeal Carcinoma.
Chen YP, Chen L, Li WF, Lee AWM, Vermorken JB, Wee J, O'Sullivan B, Eisbruch A, Lin JC, Mai HQ, Zhang L, Guo Y, Lin AH, Sun Y, Ma J
Int J Radiat Oncol Biol Phys 2017 May 1;98(1):170-176. Epub 2017 Jan 29 doi: 10.1016/j.ijrobp.2017.01.214. PMID: 28586958
Management of isolated cricopharyngeal dysfunction: systematic review.
Ashman A, Dale OT, Baldwin DL
J Laryngol Otol 2016 Jul;130(7):611-5. Epub 2016 May 19 doi: 10.1017/S0022215116007994. PMID: 27194375
Oropharyngeal histoplasmosis: report of eleven cases and review of the literature.
Antonello VS, Zaltron VF, Vial M, Oliveira FM, Severo LC
Rev Soc Bras Med Trop 2011 Jan-Feb;44(1):26-9. doi: 10.1590/s0037-86822011000100007. PMID: 21340403
Laryngopharyngeal reflux and chronic sinusitis.
Weldon D
Curr Allergy Asthma Rep 2007 Jun;7(3):197-201. doi: 10.1007/s11882-007-0072-5. PMID: 17448331

Prognosis

Risk factor of pharyngocutaneous fistula.
Kedous S, Turki S, Elhedhili F, Dhambri S, Jbeli S, Touati S, Gritli S
Tunis Med 2019 Mar;97(3):491-499. PMID: 31729725
Congenital Neck Masses.
Quintanilla-Dieck L, Penn EB Jr
Clin Perinatol 2018 Dec;45(4):769-785. Epub 2018 Sep 18 doi: 10.1016/j.clp.2018.07.012. PMID: 30396417
Nasopharyngeal adenocarcinoma: A population-based analysis.
Kuan EC, Alonso JE, Arshi A, St John MA
Am J Otolaryngol 2017 May-Jun;38(3):297-300. Epub 2017 Jan 31 doi: 10.1016/j.amjoto.2017.01.028. PMID: 28173955
Congenital lesions of epithelial origin.
Hills SE, Maddalozzo J
Otolaryngol Clin North Am 2015 Feb;48(1):209-23. doi: 10.1016/j.otc.2014.09.014. PMID: 25439555
Pharyngocutaneous fistula.
Mäkitie AA, Irish J, Gullane PJ
Curr Opin Otolaryngol Head Neck Surg 2003 Apr;11(2):78-84. doi: 10.1097/00020840-200304000-00003. PMID: 14515083

Clinical prediction guides

Clinical parameters predicting tonsillar malignancy.
Fellner A, Gavriel H, Pitaro J, Muallem Kalmovich L
Eur Arch Otorhinolaryngol 2020 Jun;277(6):1779-1783. Epub 2020 Mar 4 doi: 10.1007/s00405-020-05873-4. PMID: 32130510
Risk factor of pharyngocutaneous fistula.
Kedous S, Turki S, Elhedhili F, Dhambri S, Jbeli S, Touati S, Gritli S
Tunis Med 2019 Mar;97(3):491-499. PMID: 31729725
Oropharyngeal lesions in pityriasis rosea.
Ciccarese G, Broccolo F, Rebora A, Parodi A, Drago F
J Am Acad Dermatol 2017 Nov;77(5):833-837.e4. Epub 2017 Jul 18 doi: 10.1016/j.jaad.2017.06.033. PMID: 28728872
Making sense out of the tonsillectomy literature.
Mink JW, Shaha SH, Brodsky L
Int J Pediatr Otorhinolaryngol 2009 Nov;73(11):1499-506. Epub 2009 Apr 5 doi: 10.1016/j.ijporl.2009.02.022. PMID: 19346010
Dysphagia bedside screening for acute-stroke patients: the Gugging Swallowing Screen.
Trapl M, Enderle P, Nowotny M, Teuschl Y, Matz K, Dachenhausen A, Brainin M
Stroke 2007 Nov;38(11):2948-52. Epub 2007 Sep 20 doi: 10.1161/STROKEAHA.107.483933. PMID: 17885261

Recent systematic reviews

The global prevalence of oropharyngeal dysphagia in different populations: a systematic review and meta-analysis.
Rajati F, Ahmadi N, Naghibzadeh ZA, Kazeminia M
J Transl Med 2022 Apr 11;20(1):175. doi: 10.1186/s12967-022-03380-0. PMID: 35410274Free PMC Article
Consensus on the treatment of dysphagia in Parkinson's disease.
Schindler A, Pizzorni N, Cereda E, Cosentino G, Avenali M, Montomoli C, Abbruzzese G, Antonini A, Barbiera F, Benazzo M, Benarroch E, Bertino G, Clavè P, Cortelli P, Eleopra R, Ferrari C, Hamdy S, Huckabee ML, Lopiano L, Marchese-Ragona R, Masiero S, Michou E, Occhini A, Pacchetti C, Pfeiffer RF, Restivo DA, Rondanelli M, Ruoppolo G, Sandrini G, Schapira A, Stocchi F, Tolosa E, Valentino F, Zamboni M, Zangaglia R, Zappia M, Tassorelli C, Alfonsi E
J Neurol Sci 2021 Nov 15;430:120008. Epub 2021 Sep 27 doi: 10.1016/j.jns.2021.120008. PMID: 34624796
Interventions to prevent aspiration in older adults with dysphagia living in nursing homes: a scoping review.
Chen S, Kent B, Cui Y
BMC Geriatr 2021 Jul 17;21(1):429. doi: 10.1186/s12877-021-02366-9. PMID: 34273953Free PMC Article
Neurogenic Dysphagia: Systematic Review and Proposal of a Classification System.
Warnecke T, Labeit B, Schroeder J, Reckels A, Ahring S, Lapa S, Claus I, Muhle P, Suntrup-Krueger S, Dziewas R
Neurology 2021 Feb 9;96(6):e876-e889. Epub 2020 Dec 14 doi: 10.1212/WNL.0000000000011350. PMID: 33318164
Dysphagia after stroke: incidence, diagnosis, and pulmonary complications.
Martino R, Foley N, Bhogal S, Diamant N, Speechley M, Teasell R
Stroke 2005 Dec;36(12):2756-63. Epub 2005 Nov 3 doi: 10.1161/01.STR.0000190056.76543.eb. PMID: 16269630

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