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Pulmonary tuberculosis

MedGen UID:
11947
•Concept ID:
C0041327
•
Disease or Syndrome
Synonyms: Consumption, Pulmonary; Consumptions, Pulmonary; Phthises, Pulmonary; Phthisis, Pulmonary; Pulmonary Consumption; Pulmonary Consumptions; Pulmonary Phthises; Pulmonary Phthisis; Pulmonary Tuberculoses; Pulmonary Tuberculosis; Tuberculoses, Pulmonary; Tuberculosis, Pulmonary
SNOMED CT: PTB - Pulmonary tuberculosis (154283005); TB - Pulmonary tuberculosis (154283005); Pulmonary tuberculosis (154283005); Tuberculosis of respiratory system (700272008); Respiratory tuberculosis (700272008)
 
HPO: HP:0032262
Monarch Initiative: MONDO:0006052

Definition

A lung infection by Mycobacterium tuberculosis a slightly curved non-motile, aerobic, non-capsulated and non-spore forming strains of mycobacteria. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary tuberculosis

Conditions with this feature

X-linked Mendelian susceptibility to mycobacterial diseases due to CYBB deficiency
MedGen UID:
370369
•Concept ID:
C1970859
•
Disease or Syndrome
IMD34 results in predisposition to infections by poorly virulent mycobacteria, such as bacillus Calmette-Guerin (BCG) vaccines and nontuberculous environmental bacteria. Affected individuals are also susceptible to the more virulent species Mycobacterium tuberculosis (Bustamante et al., 2007).
See: Condition Record
X-linked Mendelian susceptibility to mycobacterial diseases due to CYBB deficiency

Professional guidelines

PubMed

Review of advances in diagnosis and treatment of pulmonary tuberculosis.
Tendolkar MS, Tyagi R, Handa A
Indian J Tuberc 2021 Oct;68(4):510-515. Epub 2021 Jul 7 doi: 10.1016/j.ijtb.2021.07.002. PMID: 34752322
Current Medical Management of Pulmonary Tuberculosis.
Belknap RW
Thorac Surg Clin 2019 Feb;29(1):27-35. doi: 10.1016/j.thorsurg.2018.09.004. PMID: 30454919
Pulmonary Tuberculosis: Role of Radiology in Diagnosis and Management.
Nachiappan AC, Rahbar K, Shi X, Guy ES, Mortani Barbosa EJ Jr, Shroff GS, Ocazionez D, Schlesinger AE, Katz SI, Hammer MM
Radiographics 2017 Jan-Feb;37(1):52-72. doi: 10.1148/rg.2017160032. PMID: 28076011

Recent clinical studies

Etiology

Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis.
Aggarwal AN, Agarwal R, Dhooria S, Prasad KT, Sehgal IS, Muthu V
PLoS One 2021;16(10):e0259006. Epub 2021 Oct 21 doi: 10.1371/journal.pone.0259006. PMID: 34673822Free PMC Article
Transbronchial tuberculosis cavity plugging therapy for pulmonary tuberculosis.
Han J, Yuan L, Li J, Liang C, Zhang D, Mei Z
J Int Med Res 2021 Aug;49(8):3000605211035889. doi: 10.1177/03000605211035889. PMID: 34463564Free PMC Article
Overt and Subclinical Adrenal Insufficiency in Pulmonary Tuberculosis.
Neogi S, Mukhopadhyay P, Sarkar N, Datta PK, Basu M, Ghosh S
Endocr Pract 2021 Jun;27(6):601-606. Epub 2020 Dec 14 doi: 10.1016/j.eprac.2020.11.012. PMID: 33645514
Mapping the epidemiology and trends of extra-pulmonary tuberculosis in Saudi Arabia.
Varghese B, Al-Hajoj S
Int J Mycobacteriol 2015 Dec;4(4):261-9. Epub 2015 Jul 15 doi: 10.1016/j.ijmyco.2015.06.002. PMID: 26964806
Gastrointestinal tuberculosis.
Sheer TA, Coyle WJ
Curr Gastroenterol Rep 2003 Aug;5(4):273-8. doi: 10.1007/s11894-003-0063-1. PMID: 12864956

Diagnosis

Review of advances in diagnosis and treatment of pulmonary tuberculosis.
Tendolkar MS, Tyagi R, Handa A
Indian J Tuberc 2021 Oct;68(4):510-515. Epub 2021 Jul 7 doi: 10.1016/j.ijtb.2021.07.002. PMID: 34752322
Overt and Subclinical Adrenal Insufficiency in Pulmonary Tuberculosis.
Neogi S, Mukhopadhyay P, Sarkar N, Datta PK, Basu M, Ghosh S
Endocr Pract 2021 Jun;27(6):601-606. Epub 2020 Dec 14 doi: 10.1016/j.eprac.2020.11.012. PMID: 33645514
Intrathoracic tuberculous lymphadenopathy in children: a guide to chest radiography.
George A, Andronikou S, Pillay T, Goussard P, Zar HJ
Pediatr Radiol 2017 Sep;47(10):1277-1282. Epub 2017 Aug 29 doi: 10.1007/s00247-017-3890-1. PMID: 29052774Free PMC Article
Making a timely diagnosis of pulmonary tuberculosis.
Long R
Can Respir J 2015 Nov-Dec;22(6):317-21. Epub 2015 Oct 15 doi: 10.1155/2015/826035. PMID: 26469154Free PMC Article
Congenital pulmonary tuberculosis.
Chakrabarti R, Mittal M, Yadav BS, Wazir S
Arch Dis Child Fetal Neonatal Ed 2014 Jan;99(1):F20. Epub 2013 Jul 5 doi: 10.1136/archdischild-2013-303909. PMID: 23833073

Therapy

TB-PRACTECAL: study protocol for a randomised, controlled, open-label, phase II-III trial to evaluate the safety and efficacy of regimens containing bedaquiline and pretomanid for the treatment of adult patients with pulmonary multidrug-resistant tuberculosis.
Berry C, du Cros P, Fielding K, Gajewski S, Kazounis E, McHugh TD, Merle C, Motta I, Moore DAJ, Nyang'wa BT
Trials 2022 Jun 13;23(1):484. doi: 10.1186/s13063-022-06331-8. PMID: 35698158Free PMC Article
ADVANCES IN PHARMACOTHERAPY OF TUBERCULOSIS.
Pstragowski M, Zbrzezna M, Bujalska-Zadrozny M
Acta Pol Pharm 2017 Jan;74(1):3-11. PMID: 29474756
Bedaquiline.
Goulooze SC, Cohen AF, Rissmann R
Br J Clin Pharmacol 2015 Aug;80(2):182-4. Epub 2015 Jul 2 doi: 10.1111/bcp.12613. PMID: 25702772Free PMC Article
Endobronchial tuberculosis.
Rikimaru T
Expert Rev Anti Infect Ther 2004 Apr;2(2):245-51. doi: 10.1586/14787210.2.2.245. PMID: 15482190
Rifapentine.
Jarvis B, Lamb HM
Drugs 1998 Oct;56(4):607-16; discussion 617. doi: 10.2165/00003495-199856040-00008. PMID: 9806107

Prognosis

Nutritional supplementation to prevent tuberculosis incidence in household contacts of patients with pulmonary tuberculosis in India (RATIONS): a field-based, open-label, cluster-randomised, controlled trial.
Bhargava A, Bhargava M, Meher A, Benedetti A, Velayutham B, Sai Teja G, Watson B, Barik G, Pathak RR, Prasad R, Dayal R, Madhukeshwar AK, Chadha V, Pai M, Joshi R, Menzies D, Swaminathan S
Lancet 2023 Aug 19;402(10402):627-640. Epub 2023 Aug 8 doi: 10.1016/S0140-6736(23)01231-X. PMID: 37567200
Age-period-cohort analysis of pulmonary tuberculosis reported incidence, China, 2006-2020.
Dong Z, Wang QQ, Yu SC, Huang F, Liu JJ, Yao HY, Zhao YL
Infect Dis Poverty 2022 Jul 28;11(1):85. doi: 10.1186/s40249-022-01009-4. PMID: 35902982Free PMC Article
Drug resistance and tuberculosis elimination in low-incidence countries.
Falzon D, Zellweger JP, Migliori GB, Jaramillo E
Eur Respir J 2014 Dec;44(6):1408-11. doi: 10.1183/09031936.00138014. PMID: 25435527
Tuberculous meningitis.
Garg RK
Acta Neurol Scand 2010 Aug;122(2):75-90. Epub 2010 Jan 6 doi: 10.1111/j.1600-0404.2009.01316.x. PMID: 20055767
Pulmonary tuberculosis.
Hirsch CS, Johnson JL, Ellner JJ
Curr Opin Pulm Med 1999 May;5(3):143-50. doi: 10.1097/00063198-199905000-00004. PMID: 10228738

Clinical prediction guides

Tuberculosis in children: screening, diagnosis and management.
Howard-Jones AR, Marais BJ
Curr Opin Pediatr 2020 Jun;32(3):395-404. doi: 10.1097/MOP.0000000000000897. PMID: 32374579
Value of procalcitonin in differentiating pulmonary tuberculosis from other pulmonary infections: a meta-analysis.
Huang SL, Lee HC, Yu CW, Chen HC, Wang CC, Wu JY, Lee CC
Int J Tuberc Lung Dis 2014 Apr;18(4):470-7. doi: 10.5588/ijtld.13.0449. PMID: 24670705
Delays in diagnosis and treatment of pulmonary tuberculosis in India: a systematic review.
Sreeramareddy CT, Qin ZZ, Satyanarayana S, Subbaraman R, Pai M
Int J Tuberc Lung Dis 2014 Mar;18(3):255-266. doi: 10.5588/ijtld.13.0585. PMID: 24670558Free PMC Article
Chronic inactive pulmonary tuberculosis and treatment sequelae: chest radiographic features.
Hicks A, Muthukumarasamy S, Maxwell D, Howlett D
Int J Tuberc Lung Dis 2014 Feb;18(2):128-33. doi: 10.5588/ijtld.13.0360. PMID: 24429302
Advances in the diagnosis of pulmonary tuberculosis in HIV-infected and HIV-uninfected children.
Connell TG, Zar HJ, Nicol MP
J Infect Dis 2011 Nov 15;204 Suppl 4(Suppl 4):S1151-8. doi: 10.1093/infdis/jir413. PMID: 21996697Free PMC Article

Recent systematic reviews

The natural history of untreated pulmonary tuberculosis in adults: a systematic review and meta-analysis.
Sossen B, Richards AS, Heinsohn T, Frascella B, Balzarini F, Oradini-Alacreu A, Odone A, Rogozinska E, Häcker B, Cobelens F, Kranzer K, Houben RMGJ, Esmail H
Lancet Respir Med 2023 Apr;11(4):367-379. Epub 2023 Mar 23 doi: 10.1016/S2213-2600(23)00097-8. PMID: 36966795
Post-tuberculosis sequelae in children and adolescents: a systematic review.
Igbokwe V, Ruby LC, Sultanli A, Bélard S
Lancet Infect Dis 2023 Apr;23(4):e138-e150. doi: 10.1016/S1473-3099(23)00004-X. PMID: 36963920
Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis.
Martinez L, Cords O, Liu Q, Acuna-Villaorduna C, Bonnet M, Fox GJ, Carvalho ACC, Chan PC, Croda J, Hill PC, Lopez-Varela E, Donkor S, Fielding K, Graham SM, Espinal MA, Kampmann B, Reingold A, Huerga H, Villalba JA, Grandjean L, Sotgiu G, Egere U, Singh S, Zhu L, Lienhardt C, Denholm JT, Seddon JA, Whalen CC, García-Basteiro AL, Triasih R, Chen C, Singh J, Huang LM, Sharma S, Hannoun D, Del Corral H, Mandalakas AM, Malone LL, Ling DL, Kritski A, Stein CM, Vashishtha R, Boulahbal F, Fang CT, Boom WH, Netto EM, Lemos AC, Hesseling AC, Kay A, Jones-López EC, Horsburgh CR, Lange C, Andrews JR
Lancet Glob Health 2022 Sep;10(9):e1307-e1316. doi: 10.1016/S2214-109X(22)00283-2. PMID: 35961354Free PMC Article
Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and amikacin.
Pillay S, Steingart KR, Davies GR, Chaplin M, De Vos M, Schumacher SG, Warren R, Theron G
Cochrane Database Syst Rev 2022 May 18;5(5):CD014841. doi: 10.1002/14651858.CD014841.pub2. PMID: 35583175Free PMC Article
A systemic review on tuberculosis.
Natarajan A, Beena PM, Devnikar AV, Mali S
Indian J Tuberc 2020 Jul;67(3):295-311. Epub 2020 Feb 28 doi: 10.1016/j.ijtb.2020.02.005. PMID: 32825856

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