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Lip and oral cavity squamous cell carcinoma

MedGen UID:
124714
•Concept ID:
C0280297
•
Neoplastic Process
Synonyms: lip and oral cavity squamous cell cancer; Lip and Oral Cavity Squamous Cell Carcinoma; lip and oral cavity squamous cell carcinoma; lip/oral cavity squam. cell car.; squamous cell carcinoma of oral cavity and lip; Squamous cell carcinoma of oral cavity and lip
 
Monarch Initiative: MONDO:0044710
Orphanet: ORPHA502369

Definition

A squamous cell carcinoma arising from the lip or the oral cavity. The oral cavity squamous cell carcinoma usually arises from the buccal mucosa, tongue, or gums. It occurs predominantly in adults who use tobacco and alcohol and has a tendency to metastasize early to lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLip and oral cavity squamous cell carcinoma

Professional guidelines

PubMed

Potential Alternative Therapeutic Modalities for Management Head and Neck Squamous Cell Carcinoma: A Review.
Afshari K, Sohal KS
Cancer Control 2023 Jan-Dec;30:10732748231185003. doi: 10.1177/10732748231185003. PMID: 37328298Free PMC Article
Interstitial Brachytherapy for Lip Cancer: Technical Aspects to Individualize Treatment Approach and Optimize Outcomes.
Merfeld EC, Witek ME, Francis DM, Burr AR, Wallace CR, Kuczmarska-Haas A, Lamichhane N, Kimple RJ, Glazer TA, Wieland AM, McCulloch TM, Hartig GK, Harari PM
Pract Radiat Oncol 2023 Jul-Aug;13(4):340-345. Epub 2023 Jan 25 doi: 10.1016/j.prro.2023.01.004. PMID: 36709044Free PMC Article
Management of high-risk squamous cell carcinoma of the skin.
Samarasinghe V, Madan V, Lear JT
Expert Rev Anticancer Ther 2011 May;11(5):763-9. doi: 10.1586/era.11.36. PMID: 21554051

Recent clinical studies

Etiology

Nodal Metastasis in Surgically Treated Oral Cavity Squamous Cell Carcinoma.
Carey RM, Anagnos VJ, Prasad A, Sangal NR, Rajasekaran K, Shanti RM, Cannady SB, Newman JG, Brant JA, Brody RM
ORL J Otorhinolaryngol Relat Spec 2023;85(6):348-359. Epub 2023 Nov 15 doi: 10.1159/000534491. PMID: 37967536Free PMC Article
Lip and Oral Cavity Squamous Cell Carcinoma.
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Oral squamous cell carcinoma resection and neck dissection mortality: a 10-year national audit study.
Ong YLR, Sambrook P, Maddern G
ANZ J Surg 2021 Jan;91(1-2):145-151. Epub 2020 Nov 27 doi: 10.1111/ans.16463. PMID: 33244898
Lymphangiogenesis and angiogenesis in oral cavity and lower lip squamous cell carcinoma.
Alaeddini M, Etemad-Moghadam S
Braz J Otorhinolaryngol 2016 Jul-Aug;82(4):385-90. Epub 2015 Nov 5 doi: 10.1016/j.bjorl.2015.06.008. PMID: 26614046Free PMC Article
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013

Diagnosis

Lip Squamous Cell Carcinoma With Spontaneous Eruption and Drainage.
Toni T, Allen CT, Mydlarz WK
JAMA Otolaryngol Head Neck Surg 2023 Mar 1;149(3):280-281. doi: 10.1001/jamaoto.2022.4828. PMID: 36729450Free PMC Article
Lip and Oral Cavity Squamous Cell Carcinoma.
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Oral Biopsy Techniques.
Shanti RM, Tanaka T, Stanton DC
Dermatol Clin 2020 Oct;38(4):421-427. Epub 2020 Aug 10 doi: 10.1016/j.det.2020.05.003. PMID: 32892851
Squamous cell carcinoma of the head and neck in children.
Dombrowski ND, Wolter NE, Irace AL, Robson CD, Perez-Atayde AR, Mack JW, Rahbar R
Int J Pediatr Otorhinolaryngol 2019 Feb;117:131-137. Epub 2018 Nov 20 doi: 10.1016/j.ijporl.2018.11.019. PMID: 30579067
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects.
Vieira RA, Minicucci EM, Marques ME, Marques SA
An Bras Dermatol 2012 Jan-Feb;87(1):105-14. doi: 10.1590/s0365-05962012000100013. PMID: 22481658

Therapy

5-Aminolevulinic acid photodynamic therapy for early-stage lip squamous cell carcinoma.
Wang P, Zhang G, Zhang L, Zhou Z, Shi L, Zeng Q, Zhu L, Wang X
Photodiagnosis Photodyn Ther 2021 Sep;35:102321. Epub 2021 May 17 doi: 10.1016/j.pdpdt.2021.102321. PMID: 34015543
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Squamous cell carcinoma of the head and neck in children.
Dombrowski ND, Wolter NE, Irace AL, Robson CD, Perez-Atayde AR, Mack JW, Rahbar R
Int J Pediatr Otorhinolaryngol 2019 Feb;117:131-137. Epub 2018 Nov 20 doi: 10.1016/j.ijporl.2018.11.019. PMID: 30579067
A Review of Photodynamic Therapy for Neoplasms of the Head and Neck.
Civantos FJ, Karakullukcu B, Biel M, Silver CE, Rinaldo A, Saba NF, Takes RP, Vander Poorten V, Ferlito A
Adv Ther 2018 Mar;35(3):324-340. Epub 2018 Feb 7 doi: 10.1007/s12325-018-0659-3. PMID: 29417455
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects.
Vieira RA, Minicucci EM, Marques ME, Marques SA
An Bras Dermatol 2012 Jan-Feb;87(1):105-14. doi: 10.1590/s0365-05962012000100013. PMID: 22481658

Prognosis

Nodal Metastasis in Surgically Treated Oral Cavity Squamous Cell Carcinoma.
Carey RM, Anagnos VJ, Prasad A, Sangal NR, Rajasekaran K, Shanti RM, Cannady SB, Newman JG, Brant JA, Brody RM
ORL J Otorhinolaryngol Relat Spec 2023;85(6):348-359. Epub 2023 Nov 15 doi: 10.1159/000534491. PMID: 37967536Free PMC Article
Clinicopathologic Characteristics of Young Patients with Oral Squamous Cell Carcinoma.
Mneimneh WS, Xu B, Ghossein C, Alzumaili B, Sethi S, Ganly I, Khimraj A, Dogan S, Katabi N
Head Neck Pathol 2021 Dec;15(4):1099-1108. Epub 2021 Apr 2 doi: 10.1007/s12105-021-01320-w. PMID: 33797696Free PMC Article
Evaluation and Prognostic Significance of Galectin-3 Expression in Oral Squamous Cell Carcinoma.
Tokmak S, Arık D, Pınarbaşlı Ö, Gürbüz MK, Açıkalın MF
Ear Nose Throat J 2021 Sep;100(5_suppl):578S-583S. Epub 2019 Dec 15 doi: 10.1177/0145561319893861. PMID: 31838918
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects.
Vieira RA, Minicucci EM, Marques ME, Marques SA
An Bras Dermatol 2012 Jan-Feb;87(1):105-14. doi: 10.1590/s0365-05962012000100013. PMID: 22481658

Clinical prediction guides

Nodal Metastasis in Surgically Treated Oral Cavity Squamous Cell Carcinoma.
Carey RM, Anagnos VJ, Prasad A, Sangal NR, Rajasekaran K, Shanti RM, Cannady SB, Newman JG, Brant JA, Brody RM
ORL J Otorhinolaryngol Relat Spec 2023;85(6):348-359. Epub 2023 Nov 15 doi: 10.1159/000534491. PMID: 37967536Free PMC Article
Evaluation and Prognostic Significance of Galectin-3 Expression in Oral Squamous Cell Carcinoma.
Tokmak S, Arık D, Pınarbaşlı Ö, Gürbüz MK, Açıkalın MF
Ear Nose Throat J 2021 Sep;100(5_suppl):578S-583S. Epub 2019 Dec 15 doi: 10.1177/0145561319893861. PMID: 31838918
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Lymphangiogenesis and angiogenesis in oral cavity and lower lip squamous cell carcinoma.
Alaeddini M, Etemad-Moghadam S
Braz J Otorhinolaryngol 2016 Jul-Aug;82(4):385-90. Epub 2015 Nov 5 doi: 10.1016/j.bjorl.2015.06.008. PMID: 26614046Free PMC Article
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013

Recent systematic reviews

Risk of head and neck cancer among opium users.
Mohebbi E, Alimoradi Z, Rozek LS, Mohebbi A, Jafari E
Arch Oral Biol 2024 Jan;157:105846. Epub 2023 Nov 8 doi: 10.1016/j.archoralbio.2023.105846. PMID: 37980840
Hydrochlorothiazide use is associated with the risk of cutaneous and lip squamous cell carcinoma: A systematic review and meta-analysis.
de Macedo Andrade AC, Felix FA, França GM, Ribeiro ILA, Barboza CAG, de Castro RD, de Lisboa Lopes Costa A
Eur J Clin Pharmacol 2022 Jun;78(6):919-930. Epub 2022 Mar 8 doi: 10.1007/s00228-022-03299-x. PMID: 35258665
Primary Intraosseous Squamous Cell Carcinoma Involving the Jaw Bones: A Systematic Review and Update.
de Morais EF, Carlan LM, de Farias Morais HG, Pinheiro JC, Martins HDD, Barboza CAG, de Almeida Freitas R
Head Neck Pathol 2021 Jun;15(2):608-616. Epub 2020 Oct 12 doi: 10.1007/s12105-020-01234-z. PMID: 33044723Free PMC Article
Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.
Macey R, Walsh T, Brocklehurst P, Kerr AR, Liu JL, Lingen MW, Ogden GR, Warnakulasuriya S, Scully C
Cochrane Database Syst Rev 2015 May 29;2015(5):CD010276. doi: 10.1002/14651858.CD010276.pub2. PMID: 26021841Free PMC Article
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013

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