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Infantile Hemangioma

MedGen UID:
1380698
•Concept ID:
C4317089
•
Neoplastic Process
Synonyms: Cellular Hemangioma; Infantile Hemangioendothelioma; Infantile hemangioma; Juvenile Capillary Hemangioma; Juvenile Hemangioma; Strawberry Nevus
SNOMED CT: Infantile hemangioma (1293125002)

Definition

A capillary hemangioma that may regress spontaneously. It occurs in infants and children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfantile Hemangioma

Professional guidelines

PubMed

Infantile hemangioma. Part 2: Management.
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
PHACE Syndrome: Consensus-Derived Diagnosis and Care Recommendations.
Garzon MC, Epstein LG, Heyer GL, Frommelt PC, Orbach DB, Baylis AL, Blei F, Burrows PE, Chamlin SL, Chun RH, Hess CP, Joachim S, Johnson K, Kim W, Liang MG, Maheshwari M, McCoy GN, Metry DW, Monrad PA, Pope E, Powell J, Shwayder TA, Siegel DH, Tollefson MM, Vadivelu S, Lew SM, Frieden IJ, Drolet BA
J Pediatr 2016 Nov;178:24-33.e2. Epub 2016 Sep 19 doi: 10.1016/j.jpeds.2016.07.054. PMID: 27659028Free PMC Article
Diagnosis and management of infantile hemangiomas.
Püttgen KB
Pediatr Clin North Am 2014 Apr;61(2):383-402. Epub 2014 Feb 18 doi: 10.1016/j.pcl.2013.11.010. PMID: 24636652

Recent clinical studies

Etiology

Infantile hemangioma. Part 2: Management.
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
Efficacy and Safety of Topical Timolol for the Treatment of Infantile Hemangioma in the Early Proliferative Stage: A Randomized Clinical Trial.
Muñoz-Garza FZ, Ríos M, Roé-Crespo E, Bernabeu-Wittel J, Montserrat-García MT, Puig L, Gich I, Baselga E
JAMA Dermatol 2021 May 1;157(5):583-587. doi: 10.1001/jamadermatol.2021.0596. PMID: 33825828Free PMC Article
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
PHACE Syndrome: Consensus-Derived Diagnosis and Care Recommendations.
Garzon MC, Epstein LG, Heyer GL, Frommelt PC, Orbach DB, Baylis AL, Blei F, Burrows PE, Chamlin SL, Chun RH, Hess CP, Joachim S, Johnson K, Kim W, Liang MG, Maheshwari M, McCoy GN, Metry DW, Monrad PA, Pope E, Powell J, Shwayder TA, Siegel DH, Tollefson MM, Vadivelu S, Lew SM, Frieden IJ, Drolet BA
J Pediatr 2016 Nov;178:24-33.e2. Epub 2016 Sep 19 doi: 10.1016/j.jpeds.2016.07.054. PMID: 27659028Free PMC Article
Infantile hemangioma.
Holland KE, Drolet BA
Pediatr Clin North Am 2010 Oct;57(5):1069-83. Epub 2010 Aug 21 doi: 10.1016/j.pcl.2010.07.008. PMID: 20888458

Diagnosis

Infantile hemangioma. Part 1: Epidemiology, pathogenesis, clinical presentation and assessment.
Rodríguez Bandera AI, Sebaratnam DF, Wargon O, Wong LF
J Am Acad Dermatol 2021 Dec;85(6):1379-1392. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.019. PMID: 34419524
Infantile hemangioma. Part 2: Management.
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
Guidance Document for Hepatic Hemangioma (Infantile and Congenital) Evaluation and Monitoring.
Iacobas I, Phung TL, Adams DM, Trenor CC 3rd, Blei F, Fishman DS, Hammill A, Masand PM, Fishman SJ
J Pediatr 2018 Dec;203:294-300.e2. Epub 2018 Sep 21 doi: 10.1016/j.jpeds.2018.08.012. PMID: 30244993
PHACE Syndrome: Consensus-Derived Diagnosis and Care Recommendations.
Garzon MC, Epstein LG, Heyer GL, Frommelt PC, Orbach DB, Baylis AL, Blei F, Burrows PE, Chamlin SL, Chun RH, Hess CP, Joachim S, Johnson K, Kim W, Liang MG, Maheshwari M, McCoy GN, Metry DW, Monrad PA, Pope E, Powell J, Shwayder TA, Siegel DH, Tollefson MM, Vadivelu S, Lew SM, Frieden IJ, Drolet BA
J Pediatr 2016 Nov;178:24-33.e2. Epub 2016 Sep 19 doi: 10.1016/j.jpeds.2016.07.054. PMID: 27659028Free PMC Article

Therapy

Infantile hemangioma: the common and enigmatic vascular tumor.
Holm A, Mulliken JB, Bischoff J
J Clin Invest 2024 Apr 15;134(8) doi: 10.1172/JCI172836. PMID: 38618963Free PMC Article
Infantile Hemangiomas.
Hasbani DJ, Hamie L
Dermatol Clin 2022 Oct;40(4):383-392. Epub 2022 Sep 16 doi: 10.1016/j.det.2022.06.004. PMID: 36243426
Infantile hemangioma. Part 2: Management.
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
Efficacy and Safety of Topical Timolol for the Treatment of Infantile Hemangioma in the Early Proliferative Stage: A Randomized Clinical Trial.
Muñoz-Garza FZ, Ríos M, Roé-Crespo E, Bernabeu-Wittel J, Montserrat-García MT, Puig L, Gich I, Baselga E
JAMA Dermatol 2021 May 1;157(5):583-587. doi: 10.1001/jamadermatol.2021.0596. PMID: 33825828Free PMC Article
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034

Prognosis

Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
Pediatric Congenital Cerebrovascular Anomalies.
Goyal P, Mangla R, Gupta S, Malhotra A, Almast J, Sapire J, Kolar B
J Neuroimaging 2019 Mar;29(2):165-181. Epub 2018 Oct 31 doi: 10.1111/jon.12575. PMID: 30378722
Guidance Document for Hepatic Hemangioma (Infantile and Congenital) Evaluation and Monitoring.
Iacobas I, Phung TL, Adams DM, Trenor CC 3rd, Blei F, Fishman DS, Hammill A, Masand PM, Fishman SJ
J Pediatr 2018 Dec;203:294-300.e2. Epub 2018 Sep 21 doi: 10.1016/j.jpeds.2018.08.012. PMID: 30244993
Head and neck vascular lesions.
Hoff SR, Rastatter JC, Richter GT
Otolaryngol Clin North Am 2015 Feb;48(1):29-45. doi: 10.1016/j.otc.2014.09.004. PMID: 25439548
Infantile hemangioma.
Holland KE, Drolet BA
Pediatr Clin North Am 2010 Oct;57(5):1069-83. Epub 2010 Aug 21 doi: 10.1016/j.pcl.2010.07.008. PMID: 20888458

Clinical prediction guides

Efficacy and Safety of Topical Timolol for the Treatment of Infantile Hemangioma in the Early Proliferative Stage: A Randomized Clinical Trial.
Muñoz-Garza FZ, Ríos M, Roé-Crespo E, Bernabeu-Wittel J, Montserrat-García MT, Puig L, Gich I, Baselga E
JAMA Dermatol 2021 May 1;157(5):583-587. doi: 10.1001/jamadermatol.2021.0596. PMID: 33825828Free PMC Article
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
Does hypoxia play a role in infantile hemangioma?
de Jong S, Itinteang T, Withers AH, Davis PF, Tan ST
Arch Dermatol Res 2016 May;308(4):219-27. Epub 2016 Mar 3 doi: 10.1007/s00403-016-1635-x. PMID: 26940670
Infantile hemangiomas: current management.
Hochman M
Facial Plast Surg Clin North Am 2014 Nov;22(4):509-21. Epub 2014 Aug 21 doi: 10.1016/j.fsc.2014.07.003. PMID: 25444725
Infantile hemangioma.
Holland KE, Drolet BA
Pediatr Clin North Am 2010 Oct;57(5):1069-83. Epub 2010 Aug 21 doi: 10.1016/j.pcl.2010.07.008. PMID: 20888458

Recent systematic reviews

Skin sequelae in patients with infantile hemangioma: a systematic review.
Li W, Kang J, Bai S, Yuan L, Liu J, Bi Y, Sun J, He Y
Eur J Pediatr 2023 Feb;182(2):479-488. Epub 2022 Nov 24 doi: 10.1007/s00431-022-04688-1. PMID: 36434402
Propranolol Therapy in Infantile Hemangioma: It Is Not Just About the Beta.
Lee JC, Modiri O, England RW, Shawber CJ, Wu JK
Plast Reconstr Surg 2021 Apr 1;147(4):875-885. doi: 10.1097/PRS.0000000000007699. PMID: 33776033
The Role of Topical Timolol in the Treatment of Infantile Hemangiomas: A Systematic Review and Meta-analysis.
Khan M, Boyce A, Prieto-Merino D, Svensson Å, Wedgeworth E, Flohr C
Acta Derm Venereol 2017 Nov 15;97(10):1167-1171. doi: 10.2340/00015555-2681. PMID: 28421234
Laser treatment of infantile hemangioma: A systematic review.
Chinnadurai S, Sathe NA, Surawicz T
Lasers Surg Med 2016 Mar;48(3):221-33. Epub 2015 Dec 29 doi: 10.1002/lsm.22455. PMID: 26711436
Propranolol versus corticosteroids in the treatment of infantile hemangioma: a systematic review and meta-analysis.
Izadpanah A, Izadpanah A, Kanevsky J, Belzile E, Schwarz K
Plast Reconstr Surg 2013 Mar;131(3):601-613. doi: 10.1097/PRS.0b013e31827c6fab. PMID: 23142941

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