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Acute Megakaryoblastic Leukemia with CBFA2T3-GLIS2

MedGen UID:
1389170
Concept ID:
C4329266
Neoplastic Process
Synonym: Acute Megakaryoblastic Leukemia with CBFA2T3::GLIS2

Definition

A non-Down syndrome acute megakaryoblastic leukemia that occurs in childhood. It is associated with CBFA2T3-GLIS2 chimeric oncogene and has an unfavorable prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Megakaryoblastic Leukemia with CBFA2T3-GLIS2

Recent clinical studies

Etiology

Du Y, Yang L, Qi S, Chen Z, Sun M, Wu M, Wu B, Tao F, Xiong H
J Pediatr Hematol Oncol 2024 Mar 1;46(2):96-103. Epub 2024 Feb 1 doi: 10.1097/MPH.0000000000002822. PMID: 38315896Free PMC Article
Chisholm KM, Smith J, Heerema-McKenney AE, Choi JK, Ries RE, Hirsch BA, Raimondi SC, Wang YC, Dang A, Alonzo TA, Sung L, Aplenc R, Gamis AS, Meshinchi S, Kahwash SB
Pediatr Blood Cancer 2023 May;70(5):e30251. Epub 2023 Feb 15 doi: 10.1002/pbc.30251. PMID: 36789545Free PMC Article
Lalonde E, Rentas S, Wertheim G, Cao K, Surrey LF, Lin F, Zhao X, Obstfeld A, Aplenc R, Luo M, Li MM
Cold Spring Harb Mol Case Stud 2021 Apr;7(2) Epub 2021 Apr 8 doi: 10.1101/mcs.a005975. PMID: 33832921Free PMC Article
Masetti R, Guidi V, Ronchini L, Bertuccio NS, Locatelli F, Pession A
Crit Rev Oncol Hematol 2019 Jun;138:132-138. Epub 2019 Apr 15 doi: 10.1016/j.critrevonc.2019.04.011. PMID: 31092368
Hara Y, Shiba N, Ohki K, Tabuchi K, Yamato G, Park MJ, Tomizawa D, Kinoshita A, Shimada A, Arakawa H, Saito AM, Kiyokawa N, Tawa A, Horibe K, Taga T, Adachi S, Taki T, Hayashi Y
Genes Chromosomes Cancer 2017 May;56(5):394-404. Epub 2017 Feb 14 doi: 10.1002/gcc.22444. PMID: 28063190

Diagnosis

Gress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, Lisi V, Khakipoor B, Rouette A, Farah A, Théret L, Aubert L, Fatima F, Audemard É, Thibault P, Bonneil É, Chagraoui J, Laramée L, Gendron P, Jouan L, Jammali S, Paré B, Simpson SM, Tran TH, Duval M, Teira P, Bittencourt H, Santiago R, Barabé F, Sauvageau G, Smith MA, Hébert J, Roux PP, Gruber TA, Lavallée VP, Wilhelm BT, Cellot S
Blood Adv 2024 Jan 9;8(1):112-129. doi: 10.1182/bloodadvances.2022008899. PMID: 37729615Free PMC Article
Neault M, Lebert-Ghali CÉ, Fournier M, Capdevielle C, Garfinkle EAR, Obermayer A, Cotton A, Boulay K, Sawchyn C, St-Amand S, Nguyen KH, Assaf B, Mercier FE, Delisle JS, Drobetsky EA, Hulea L, Shaw TI, Zuber J, Gruber TA, Melichar HJ, Mallette FA
Cell Rep 2023 Sep 26;42(9):113084. Epub 2023 Sep 15 doi: 10.1016/j.celrep.2023.113084. PMID: 37716355
Le Q, Hadland B, Smith JL, Leonti A, Huang BJ, Ries R, Hylkema TA, Castro S, Tang TT, McKay CN, Perkins L, Pardo L, Sarthy J, Beckman AK, Williams R, Idemmili R, Furlan S, Ishida T, Call L, Srivastava S, Loeb AM, Milano F, Imren S, Morris SM, Pakiam F, Olson JM, Loken MR, Brodersen L, Riddell SR, Tarlock K, Bernstein ID, Loeb KR, Meshinchi S
J Clin Invest 2022 Nov 15;132(22) doi: 10.1172/JCI157101. PMID: 36136600Free PMC Article
Masetti R, Bertuccio SN, Pession A, Locatelli F
Br J Haematol 2019 Feb;184(3):337-347. Epub 2018 Dec 28 doi: 10.1111/bjh.15725. PMID: 30592296Free PMC Article
de Rooij JD, Branstetter C, Ma J, Li Y, Walsh MP, Cheng J, Obulkasim A, Dang J, Easton J, Verboon LJ, Mulder HL, Zimmermann M, Koss C, Gupta P, Edmonson M, Rusch M, Lim JY, Reinhardt K, Pigazzi M, Song G, Yeoh AE, Shih LY, Liang DC, Halene S, Krause DS, Zhang J, Downing JR, Locatelli F, Reinhardt D, van den Heuvel-Eibrink MM, Zwaan CM, Fornerod M, Gruber TA
Nat Genet 2017 Mar;49(3):451-456. Epub 2017 Jan 23 doi: 10.1038/ng.3772. PMID: 28112737Free PMC Article

Therapy

Jetten AM
Trends Cancer 2019 Sep;5(9):547-557. Epub 2019 Aug 20 doi: 10.1016/j.trecan.2019.07.005. PMID: 31474360Free PMC Article
Masetti R, Bertuccio SN, Astolfi A, Chiarini F, Lonetti A, Indio V, De Luca M, Bandini J, Serravalle S, Franzoni M, Pigazzi M, Martelli AM, Basso G, Locatelli F, Pession A
J Hematol Oncol 2017 Jan 21;10(1):26. doi: 10.1186/s13045-017-0396-0. PMID: 28109323Free PMC Article

Prognosis

Gillam J, Catic A, Paulraj P, Dalton J, Lai G, Jackson-Cook C, Turner S, Ferreira-Gonzalez A, Barrie E
Genes Chromosomes Cancer 2022 Aug;61(8):491-496. Epub 2022 Mar 30 doi: 10.1002/gcc.23039. PMID: 35294081Free PMC Article
Masetti R, Guidi V, Ronchini L, Bertuccio NS, Locatelli F, Pession A
Crit Rev Oncol Hematol 2019 Jun;138:132-138. Epub 2019 Apr 15 doi: 10.1016/j.critrevonc.2019.04.011. PMID: 31092368
Masetti R, Bertuccio SN, Pession A, Locatelli F
Br J Haematol 2019 Feb;184(3):337-347. Epub 2018 Dec 28 doi: 10.1111/bjh.15725. PMID: 30592296Free PMC Article
Dang J, Nance S, Ma J, Cheng J, Walsh MP, Vogel P, Easton J, Song G, Rusch M, Gedman AL, Koss C, Downing JR, Gruber TA
Leukemia 2017 Oct;31(10):2228-2234. Epub 2017 Feb 8 doi: 10.1038/leu.2017.51. PMID: 28174417Free PMC Article
Gruber TA, Downing JR
Blood 2015 Aug 20;126(8):943-9. Epub 2015 Jul 17 doi: 10.1182/blood-2015-05-567859. PMID: 26186939Free PMC Article

Clinical prediction guides

Chisholm KM, Smith J, Heerema-McKenney AE, Choi JK, Ries RE, Hirsch BA, Raimondi SC, Wang YC, Dang A, Alonzo TA, Sung L, Aplenc R, Gamis AS, Meshinchi S, Kahwash SB
Pediatr Blood Cancer 2023 May;70(5):e30251. Epub 2023 Feb 15 doi: 10.1002/pbc.30251. PMID: 36789545Free PMC Article
Gillam J, Catic A, Paulraj P, Dalton J, Lai G, Jackson-Cook C, Turner S, Ferreira-Gonzalez A, Barrie E
Genes Chromosomes Cancer 2022 Aug;61(8):491-496. Epub 2022 Mar 30 doi: 10.1002/gcc.23039. PMID: 35294081Free PMC Article
Dang J, Nance S, Ma J, Cheng J, Walsh MP, Vogel P, Easton J, Song G, Rusch M, Gedman AL, Koss C, Downing JR, Gruber TA
Leukemia 2017 Oct;31(10):2228-2234. Epub 2017 Feb 8 doi: 10.1038/leu.2017.51. PMID: 28174417Free PMC Article
Masetti R, Bertuccio SN, Astolfi A, Chiarini F, Lonetti A, Indio V, De Luca M, Bandini J, Serravalle S, Franzoni M, Pigazzi M, Martelli AM, Basso G, Locatelli F, Pession A
J Hematol Oncol 2017 Jan 21;10(1):26. doi: 10.1186/s13045-017-0396-0. PMID: 28109323Free PMC Article
de Rooij JD, Masetti R, van den Heuvel-Eibrink MM, Cayuela JM, Trka J, Reinhardt D, Rasche M, Sonneveld E, Alonzo TA, Fornerod M, Zimmermann M, Pigazzi M, Pieters R, Meshinchi S, Zwaan CM, Locatelli F
Blood 2016 Jun 30;127(26):3424-30. Epub 2016 Apr 25 doi: 10.1182/blood-2016-01-695551. PMID: 27114462Free PMC Article

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