U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Childhood acute myeloid leukemia

MedGen UID:
65075
•Concept ID:
C0220621
•
Neoplastic Process
Synonyms: acute myeloid leukaemia of childhood; acute myeloid leukemia of childhood; childhood acute granulocytic leukaemia; childhood acute granulocytic leukemia; childhood acute myeloblastic leukaemia; Childhood Acute Myeloblastic Leukemia; childhood acute myeloblastic leukemia; childhood acute myelocytic leukaemia; childhood acute myelocytic leukemia; childhood acute myelogenous leukaemia; Childhood Acute Myelogenous Leukemia; childhood acute myelogenous leukemia; Childhood Acute Myeloid Leukemia; childhood acute myeloid leukemia; Childhood AML; childhood AML; paediatric acute myeloblastic leukaemia; paediatric acute myelocytic leukaemia; paediatric acute myelogenous leukaemia; paediatric acute myeloid leukaemia; paediatric AML; Pediatric Acute Myeloblastic Leukemia; pediatric acute myeloblastic leukemia; pediatric acute myelocytic leukemia; Pediatric Acute Myelogenous Leukemia; pediatric acute myelogenous leukemia; Pediatric Acute Myeloid Leukemia; pediatric acute myeloid leukemia; Pediatric AML; pediatric AML
 
Monarch Initiative: MONDO:0004996

Definition

Acute myeloid leukemia occurring in childhood. [from NCI]

Professional guidelines

PubMed

Current and emerging pharmacotherapy for the treatment of childhood acute myeloid leukemia.
Cuglievan B, McCall D, Robusto L, Mireles ME, Gettys SC
Expert Opin Pharmacother 2022 Dec;23(17):1915-1925. Epub 2022 Nov 13 doi: 10.1080/14656566.2022.2145186. PMID: 36346029
Treatment of Childhood Acute Myeloid Leukemia in Bulgaria.
Burnusuzov HA, Yordanova MN, Avramova BE, Yurukova NN, Bachvarov KN, Muchinova AB, Vlahova IH, Stoyanova AA, Mumdzhiev IN, Ivanova LR, Spasov NY, Peteva ET, Belcheva MI, Hristozova H, Spasova MI, Kaleva VI, Bobev D, Konstantinov DN
Folia Med (Plovdiv) 2018 Jun 1;60(2):234-240. doi: 10.1515/folmed-2017-0090. PMID: 30355812
Current Management of Childhood Acute Myeloid Leukemia.
Rubnitz JE
Paediatr Drugs 2017 Feb;19(1):1-10. doi: 10.1007/s40272-016-0200-6. PMID: 27785777

Recent clinical studies

Etiology

Acute kidney injury and childhood acute myeloid leukemia.
Limratchapong C, Sophark P, Vachvanichsanong P, McNeil EB, Chotsampancharoen T
Pediatr Nephrol 2022 Nov;37(11):2765-2770. Epub 2022 Mar 7 doi: 10.1007/s00467-022-05506-4. PMID: 35257241
Genomic architecture and treatment outcome in pediatric acute myeloid leukemia: a Children's Oncology Group report.
Vujkovic M, Attiyeh EF, Ries RE, Goodman EK, Ding Y, Kavcic M, Alonzo TA, Wang YC, Gerbing RB, Sung L, Hirsch B, Raimondi S, Gamis AS, Meshinchi S, Aplenc R
Blood 2017 Jun 8;129(23):3051-3058. Epub 2017 Apr 14 doi: 10.1182/blood-2017-03-772384. PMID: 28411282Free PMC Article
Socioeconomic status (SES) and childhood acute myeloid leukemia (AML) mortality risk: Analysis of SEER data.
Knoble NB, Alderfer MA, Hossain MJ
Cancer Epidemiol 2016 Oct;44:101-108. Epub 2016 Aug 17 doi: 10.1016/j.canep.2016.07.007. PMID: 27543948Free PMC Article
Improved survival outcome of childhood acute myeloid leukemia with intensified chemotherapy in Chinese children.
Zhai XW, Cheng FW, Lee V, Leung WK, Ng MH, Tsang KS, Shing MK, Li CK
Pediatr Hematol Oncol 2011 May;28(4):269-78. Epub 2011 Feb 23 doi: 10.3109/08880018.2010.533249. PMID: 21345081
Drug resistance in childhood acute myeloid leukemia.
Styczynski J
Curr Pharm Biotechnol 2007 Apr;8(2):59-75. doi: 10.2174/138920107780487465. PMID: 17430154

Diagnosis

Right femoral vein and right dorsal artery thrombosis in childhood acute myeloid leukemia: A case report.
Ni J, Chen M, Su Y, Gao Q, Liu L, Lu X
Medicine (Baltimore) 2023 Oct 13;102(41):e35121. doi: 10.1097/MD.0000000000035121. PMID: 37832057Free PMC Article
Acute kidney injury and childhood acute myeloid leukemia.
Limratchapong C, Sophark P, Vachvanichsanong P, McNeil EB, Chotsampancharoen T
Pediatr Nephrol 2022 Nov;37(11):2765-2770. Epub 2022 Mar 7 doi: 10.1007/s00467-022-05506-4. PMID: 35257241
Analysis of class I and II aberrations in Iraqi childhood acute myeloid leukemia using filter paper cards.
Al-Kzayer LF, Uyen le TN, Al-Jadiry MF, Al-Hadad SA, Al-Badri SA, Ghali HH, Ameen NA, Liu T, Matsuda K, Abdulkadhim JM, Al-Shujairi TA, Matti ZI, Hasan JG, Al-Abdullah HM, Al-Ani MH, Saber PA, Khalil HM, Inoshita T, Kamata M, Koike K, Sakashita K
Ann Hematol 2014 Jun;93(6):949-55. Epub 2014 Jan 25 doi: 10.1007/s00277-014-2007-2. PMID: 24464319
Epidemiology of childhood acute myeloid leukemia.
Puumala SE, Ross JA, Aplenc R, Spector LG
Pediatr Blood Cancer 2013 May;60(5):728-33. Epub 2013 Jan 9 doi: 10.1002/pbc.24464. PMID: 23303597Free PMC Article
FLT3-TKD mutation in childhood acute myeloid leukemia.
Liang DC, Shih LY, Hung IJ, Yang CP, Chen SH, Jaing TH, Liu HC, Wang LY, Chang WH
Leukemia 2003 May;17(5):883-6. doi: 10.1038/sj.leu.2402928. PMID: 12750701

Therapy

Genomic architecture and treatment outcome in pediatric acute myeloid leukemia: a Children's Oncology Group report.
Vujkovic M, Attiyeh EF, Ries RE, Goodman EK, Ding Y, Kavcic M, Alonzo TA, Wang YC, Gerbing RB, Sung L, Hirsch B, Raimondi S, Gamis AS, Meshinchi S, Aplenc R
Blood 2017 Jun 8;129(23):3051-3058. Epub 2017 Apr 14 doi: 10.1182/blood-2017-03-772384. PMID: 28411282Free PMC Article
Current Management of Childhood Acute Myeloid Leukemia.
Rubnitz JE
Paediatr Drugs 2017 Feb;19(1):1-10. doi: 10.1007/s40272-016-0200-6. PMID: 27785777
Improved survival outcome of childhood acute myeloid leukemia with intensified chemotherapy in Chinese children.
Zhai XW, Cheng FW, Lee V, Leung WK, Ng MH, Tsang KS, Shing MK, Li CK
Pediatr Hematol Oncol 2011 May;28(4):269-78. Epub 2011 Feb 23 doi: 10.3109/08880018.2010.533249. PMID: 21345081
Curing childhood acute myeloid leukemia (AML) at the half-way point: promises to keep and miles to go before we sleep.
Woods WG
Pediatr Blood Cancer 2006 May 1;46(5):565-9. doi: 10.1002/pbc.20646. PMID: 16261562
Glutathione S-transferase polymorphisms and outcome of chemotherapy in childhood acute myeloid leukemia.
Davies SM, Robison LL, Buckley JD, Tjoa T, Woods WG, Radloff GA, Ross JA, Perentesis JP
J Clin Oncol 2001 Mar 1;19(5):1279-87. doi: 10.1200/JCO.2001.19.5.1279. PMID: 11230469

Prognosis

Late outcomes in survivors of childhood acute myeloid leukemia: a report from the St. Jude Lifetime Cohort Study.
Bhatt NS, Baassiri MJ, Liu W, Bhakta N, Chemaitilly W, Ehrhardt MJ, Inaba H, Krull K, Ness KK, Rubnitz JE, Srivastava D, Robison LL, Hudson MM, Mulrooney DA
Leukemia 2021 Aug;35(8):2258-2273. Epub 2021 Jan 25 doi: 10.1038/s41375-021-01134-3. PMID: 33495497Free PMC Article
Genomic architecture and treatment outcome in pediatric acute myeloid leukemia: a Children's Oncology Group report.
Vujkovic M, Attiyeh EF, Ries RE, Goodman EK, Ding Y, Kavcic M, Alonzo TA, Wang YC, Gerbing RB, Sung L, Hirsch B, Raimondi S, Gamis AS, Meshinchi S, Aplenc R
Blood 2017 Jun 8;129(23):3051-3058. Epub 2017 Apr 14 doi: 10.1182/blood-2017-03-772384. PMID: 28411282Free PMC Article
Socioeconomic status (SES) and childhood acute myeloid leukemia (AML) mortality risk: Analysis of SEER data.
Knoble NB, Alderfer MA, Hossain MJ
Cancer Epidemiol 2016 Oct;44:101-108. Epub 2016 Aug 17 doi: 10.1016/j.canep.2016.07.007. PMID: 27543948Free PMC Article
Drug resistance in childhood acute myeloid leukemia.
Styczynski J
Curr Pharm Biotechnol 2007 Apr;8(2):59-75. doi: 10.2174/138920107780487465. PMID: 17430154
Glutathione S-transferase polymorphisms and outcome of chemotherapy in childhood acute myeloid leukemia.
Davies SM, Robison LL, Buckley JD, Tjoa T, Woods WG, Radloff GA, Ross JA, Perentesis JP
J Clin Oncol 2001 Mar 1;19(5):1279-87. doi: 10.1200/JCO.2001.19.5.1279. PMID: 11230469

Clinical prediction guides

Neurocognitive deficits in survivors of childhood acute myeloid leukemia.
Takahashi S, Sato S, Igarashi S, Dairoku H, Takiguchi Y, Takimoto T
BMC Pediatr 2022 May 21;22(1):298. doi: 10.1186/s12887-022-03369-0. PMID: 35597905Free PMC Article
Genomic architecture and treatment outcome in pediatric acute myeloid leukemia: a Children's Oncology Group report.
Vujkovic M, Attiyeh EF, Ries RE, Goodman EK, Ding Y, Kavcic M, Alonzo TA, Wang YC, Gerbing RB, Sung L, Hirsch B, Raimondi S, Gamis AS, Meshinchi S, Aplenc R
Blood 2017 Jun 8;129(23):3051-3058. Epub 2017 Apr 14 doi: 10.1182/blood-2017-03-772384. PMID: 28411282Free PMC Article
Global characteristics of childhood acute promyelocytic leukemia.
Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
Blood Rev 2015 Mar;29(2):101-25. Epub 2014 Sep 30 doi: 10.1016/j.blre.2014.09.013. PMID: 25445717Free PMC Article
Late effects of treatment in survivors of childhood acute myeloid leukemia.
Leung W, Hudson MM, Strickland DK, Phipps S, Srivastava DK, Ribeiro RC, Rubnitz JE, Sandlund JT, Kun LE, Bowman LC, Razzouk BI, Mathew P, Shearer P, Evans WE, Pui CH
J Clin Oncol 2000 Sep 15;18(18):3273-9. doi: 10.1200/JCO.2000.18.18.3273. PMID: 10986060
Late effects of intensive treatment for acute myeloid leukemia and myelodysplasia in childhood.
Liesner RJ, Leiper AD, Hann IM, Chessells JM
J Clin Oncol 1994 May;12(5):916-24. doi: 10.1200/JCO.1994.12.5.916. PMID: 8164042

Recent systematic reviews

Maternal fetal loss history and increased acute leukemia subtype risk in subsequent offspring: a systematic review and meta-analysis.
Karalexi MA, Dessypris N, Skalkidou A, Biniaris-Georgallis S-, Kalogirou ΕΙ, Thomopoulos TP, Herlenius E, Spector LG, Loutradis D, Chrousos GP, Petridou ET
Cancer Causes Control 2017 Jun;28(6):599-624. Epub 2017 Apr 11 doi: 10.1007/s10552-017-0890-2. PMID: 28401353
Maternal alcohol consumption during pregnancy and risk of childhood leukemia: systematic review and meta-analysis.
Latino-Martel P, Chan DS, Druesne-Pecollo N, Barrandon E, Hercberg S, Norat T
Cancer Epidemiol Biomarkers Prev 2010 May;19(5):1238-60. doi: 10.1158/1055-9965.EPI-09-1110. PMID: 20447918

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...