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Abnormal circulating beta globulin level

MedGen UID:
1392085
•Concept ID:
C4476797
•
Finding
HPO: HP:0025465

Definition

A deviation from the normal concentration of beta globulin. The beta globulins are a group of globular (globe-shaped) proteins in blood. [from HPO]

Professional guidelines

PubMed

MANAGEMENT OF ENDOCRINE DISEASE Hyperandrogenic states in women: pitfalls in laboratory diagnosis.
Pugeat M, Plotton I, de la Perrière AB, Raverot G, Déchaud H, Raverot V
Eur J Endocrinol 2018 Apr;178(4):R141-R154. Epub 2018 Feb 16 doi: 10.1530/EJE-17-0776. PMID: 29453202
Estradiol levels in men with congenital hypogonadotropic hypogonadism and the effects of different modalities of hormonal treatment.
Trabado S, Maione L, Salenave S, Baron S, Galland F, Bry-Gauillard H, Guiochon-Mantel A, Chanson P, Pitteloud N, Sinisi AA, Brailly-Tabard S, Young J
Fertil Steril 2011 Jun;95(7):2324-9, 2329.e1-3. Epub 2011 May 4 doi: 10.1016/j.fertnstert.2011.03.091. PMID: 21536274
Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574

Recent clinical studies

Etiology

Reproductive endocrinology of adolescent polycystic ovary syndrome.
Shayya R, Chang RJ
BJOG 2010 Jan;117(2):150-5. doi: 10.1111/j.1471-0528.2009.02421.x. PMID: 20002395
Complement mutation-associated de novo thrombotic microangiopathy following kidney transplantation.
Le Quintrec M, Lionet A, Kamar N, Karras A, Barbier S, Buchler M, Fakhouri F, Provost F, Fridman WH, Thervet E, Legendre C, Zuber J, Frémeaux-Bacchi V
Am J Transplant 2008 Aug;8(8):1694-701. Epub 2008 Jun 28 doi: 10.1111/j.1600-6143.2008.02297.x. PMID: 18557729
Soluble HLA-DR molecules in patients with HLA class II versus class I associated disorders.
Weyand CM, Jendro M, Goronzy JJ
Autoimmunity 1991;8(4):281-7. doi: 10.3109/08916939109007635. PMID: 1932512
Hormones in male breast cancer.
Ballerini P, Recchione C, Cavalleri A, Moneta R, Saccozzi R, Secreto G
Tumori 1990 Feb 28;76(1):26-8. doi: 10.1177/030089169007600106. PMID: 2321270
Diabetes, a hypercoagulable state? Hemostatic variables in newly diagnosed type 2 diabetic patients.
Hughes A, McVerry BA, Wilkinson L, Goldstone AH, Lewis D, Bloom A
Acta Haematol 1983;69(4):254-9. doi: 10.1159/000206901. PMID: 6219531

Diagnosis

MANAGEMENT OF ENDOCRINE DISEASE Hyperandrogenic states in women: pitfalls in laboratory diagnosis.
Pugeat M, Plotton I, de la Perrière AB, Raverot G, Déchaud H, Raverot V
Eur J Endocrinol 2018 Apr;178(4):R141-R154. Epub 2018 Feb 16 doi: 10.1530/EJE-17-0776. PMID: 29453202
C3 glomerulonephritis associated with a missense mutation in the factor H gene.
Sugimoto K, Fujita S, Miyazaki K, Okada M, Takemura T
Tohoku J Exp Med 2012 Jul;227(3):211-5. doi: 10.1620/tjem.227.211. PMID: 22790979
Serum androgen bioactivity in cryptorchid and noncryptorchid boys during the postnatal reproductive hormone surge.
Raivio T, Toppari J, Kaleva M, Virtanen H, Haavisto AM, Dunkel L, Jänne OA
J Clin Endocrinol Metab 2003 Jun;88(6):2597-9. doi: 10.1210/jc.2002-021676. PMID: 12788861
Clinical and biochemical investigations to evolve early diagnosis in workers involved in the manufacture of hexachlorocyclohexane.
Nigam SK, Karnik AB, Chattopadhyay P, Lakkad BC, Venkaiah K, Kashyap SK
Int Arch Occup Environ Health 1993;65(1 Suppl):S193-6. doi: 10.1007/BF00381339. PMID: 7691758
Diabetes, a hypercoagulable state? Hemostatic variables in newly diagnosed type 2 diabetic patients.
Hughes A, McVerry BA, Wilkinson L, Goldstone AH, Lewis D, Bloom A
Acta Haematol 1983;69(4):254-9. doi: 10.1159/000206901. PMID: 6219531

Therapy

Atypical haemolytic uremic syndrome complicated by microangiopathic antiphospholipid-associated syndrome.
Meglic A, Grosek S, Benedik-Dolnicar M, Avcin T
Lupus 2008 Sep;17(9):842-5. doi: 10.1177/0961203308091634. PMID: 18755867
Complement mutation-associated de novo thrombotic microangiopathy following kidney transplantation.
Le Quintrec M, Lionet A, Kamar N, Karras A, Barbier S, Buchler M, Fakhouri F, Provost F, Fridman WH, Thervet E, Legendre C, Zuber J, Frémeaux-Bacchi V
Am J Transplant 2008 Aug;8(8):1694-701. Epub 2008 Jun 28 doi: 10.1111/j.1600-6143.2008.02297.x. PMID: 18557729
Clinical and biochemical investigations to evolve early diagnosis in workers involved in the manufacture of hexachlorocyclohexane.
Nigam SK, Karnik AB, Chattopadhyay P, Lakkad BC, Venkaiah K, Kashyap SK
Int Arch Occup Environ Health 1993;65(1 Suppl):S193-6. doi: 10.1007/BF00381339. PMID: 7691758
Renal effects of prostaglandin E1 in type 2 (non-insulin-dependent) diabetic patients with subclinical nephropathy.
Ninomiya Y, Arakawa M
Diabetes Res 1989 Mar;10(3):129-34. PMID: 2680226
Acute anaphylaxis associated with serum complement depletion.
Tannenbaum H, Ruddy S, Schur PH
J Allergy Clin Immunol 1975 Sep;56(3):226-34. doi: 10.1016/0091-6749(75)90094-9. PMID: 50336

Prognosis

Physiologic and genetic evidence links hemopexin to triglycerides in mice and humans.
Lawson HA, Zayed M, Wayhart JP, Fabbrini E, Love-Gregory L, Klein S, Semenkovich CF
Int J Obes (Lond) 2017 Apr;41(4):631-638. Epub 2017 Jan 25 doi: 10.1038/ijo.2017.19. PMID: 28119529Free PMC Article
Biomarkers of alcohol consumption and related liver disease.
Niemelä O, Alatalo P
Scand J Clin Lab Invest 2010 Sep;70(5):305-12. doi: 10.3109/00365513.2010.486442. PMID: 20470213
Atypical haemolytic uremic syndrome complicated by microangiopathic antiphospholipid-associated syndrome.
Meglic A, Grosek S, Benedik-Dolnicar M, Avcin T
Lupus 2008 Sep;17(9):842-5. doi: 10.1177/0961203308091634. PMID: 18755867
Reversal of fulminant hepatic failure using an extracorporeal liver assist device.
Sussman NL, Chong MG, Koussayer T, He DE, Shang TA, Whisennand HH, Kelly JH
Hepatology 1992 Jul;16(1):60-5. doi: 10.1002/hep.1840160112. PMID: 1618484
Effect of human chorionic gonadotropin on the plasma levels of testosterone, estradiol, sex hormone binding globuline and free testosterone in Klinefelter syndrome.
Attanasio A, Blank B, Rager K, Gupta D
Endokrinologie 1982 Oct;80(2):129-34. PMID: 6891632

Clinical prediction guides

Human serum beta2-microglobulin levels: correlation with total serum IgG and placental IgG transfer in HIV-infected and non-HIV infected individuals.
de Moraes-Pinto MI, Farhat CK, Fraser WD, Hart CA, Johnson PM
J Reprod Immunol 1999 Mar;42(2):167-74. doi: 10.1016/s0165-0378(98)00083-7. PMID: 10221738
Platelet ultra-structure study in Budd-Chiari syndrome.
Dayal S, Pati HP, Pande GK, Sharma P, Saraya AK
Eur J Haematol 1995 Nov;55(5):294-301. doi: 10.1111/j.1600-0609.1995.tb00700.x. PMID: 7493675
Ocular microangiopathic syndrome in patients with acquired immunodeficiency syndrome and its relationship to alterations in cell adhesion and in blood flow.
Geier SA, Klauss V, Goebel FD
Ger J Ophthalmol 1994 Nov;3(6):414-21. PMID: 7866262
Clinical and biochemical investigations to evolve early diagnosis in workers involved in the manufacture of hexachlorocyclohexane.
Nigam SK, Karnik AB, Chattopadhyay P, Lakkad BC, Venkaiah K, Kashyap SK
Int Arch Occup Environ Health 1993;65(1 Suppl):S193-6. doi: 10.1007/BF00381339. PMID: 7691758
Hormones in male breast cancer.
Ballerini P, Recchione C, Cavalleri A, Moneta R, Saccozzi R, Secreto G
Tumori 1990 Feb 28;76(1):26-8. doi: 10.1177/030089169007600106. PMID: 2321270

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