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Abnormal proportion of naive T cells

MedGen UID:
1611359
•Concept ID:
C4531153
•
Finding
Synonyms: Abnormal naive T cell proportion; Abnormal proportion of naive thymus-derived, alpha-beta T cells
 
HPO: HP:0031396

Definition

Any abnormality in the proportion of naive T cells relative to the total number of T cells. [from HPO]

Professional guidelines

PubMed

Protein-losing Enteropathy as a Complication and/or Differential Diagnosis of Common Variable Immunodeficiency.
Sanges S, Germain N, Vignes S, Séguy D, Stabler S, Etienne N, Terriou L, Launay D, Hachulla É, Huglo D, Dubucquoi S, Labalette M, Lefèvre G
J Clin Immunol 2022 Oct;42(7):1461-1472. Epub 2022 Jun 23 doi: 10.1007/s10875-022-01299-1. PMID: 35737255
Long-lasting decrease of CD4+/CD45RA+ T cells in HCL patients after 2-chlorodeoxyadenosine (2-CdA) treatment.
Raspadori D, Rondelli D, Birtolo S, Lenoci M, Nardi G, Scalia G, Sestigiani C, Tozzi M, Marotta G, Lauria F
Leukemia 1999 Aug;13(8):1254-7. doi: 10.1038/sj.leu.2401476. PMID: 10450754

Recent clinical studies

Etiology

Associations between immune cell traits and autoimmune thyroid diseases: a bidirectional two-sample mendelian randomization study.
Cao Z, Huang J, Long X
Immunogenetics 2024 Aug;76(4):219-231. Epub 2024 Jun 28 doi: 10.1007/s00251-024-01345-9. PMID: 38940861
Adenoid lymphocyte heterogeneity in pediatric adenoid hypertrophy and obstructive sleep apnea.
Zhu Y, Wang S, Yang Y, Shen B, Wang A, Zhang X, Zhang X, Li N, Gao Z, Liu Y, Zhu J, Wei Z, Guan J, Su K, Liu F, Gu M, Yin S
Front Immunol 2023;14:1186258. Epub 2023 May 22 doi: 10.3389/fimmu.2023.1186258. PMID: 37283767Free PMC Article
Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Accelerated Maturation, Exhaustion, and Senescence of T cells in 22q11.2 Deletion Syndrome.
Smetanova J, Milota T, Rataj M, Bloomfield M, Sediva A, Klocperk A
J Clin Immunol 2022 Feb;42(2):274-285. Epub 2021 Oct 29 doi: 10.1007/s10875-021-01154-9. PMID: 34716533
T-cell abnormalities in common variable immunodeficiency: the hidden defect.
Wong GK, Huissoon AP
J Clin Pathol 2016 Aug;69(8):672-6. Epub 2016 May 6 doi: 10.1136/jclinpath-2015-203351. PMID: 27153873Free PMC Article

Diagnosis

Associations between immune cell traits and autoimmune thyroid diseases: a bidirectional two-sample mendelian randomization study.
Cao Z, Huang J, Long X
Immunogenetics 2024 Aug;76(4):219-231. Epub 2024 Jun 28 doi: 10.1007/s00251-024-01345-9. PMID: 38940861
Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus.
Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Protein-losing Enteropathy as a Complication and/or Differential Diagnosis of Common Variable Immunodeficiency.
Sanges S, Germain N, Vignes S, Séguy D, Stabler S, Etienne N, Terriou L, Launay D, Hachulla É, Huglo D, Dubucquoi S, Labalette M, Lefèvre G
J Clin Immunol 2022 Oct;42(7):1461-1472. Epub 2022 Jun 23 doi: 10.1007/s10875-022-01299-1. PMID: 35737255
Long-Term Follow-Up of Newborns with 22q11 Deletion Syndrome and Low TRECs.
Framme JL, Lundqvist C, Lundell AC, van Schouwenburg PA, Lemarquis AL, Thörn K, Lindgren S, Gudmundsdottir J, Lundberg V, Degerman S, Zetterström RH, Borte S, Hammarström L, Telemo E, Hultdin M, van der Burg M, Fasth A, Oskarsdóttir S, Ekwall O
J Clin Immunol 2022 Apr;42(3):618-633. Epub 2022 Jan 26 doi: 10.1007/s10875-021-01201-5. PMID: 35080750Free PMC Article
The Imbalance of Circulating Follicular T Helper Cell Subsets in Primary Sjögren's Syndrome Associates With Serological Alterations and Abnormal B-Cell Distribution.
Szabó K, Jámbor I, Szántó A, Horváth IF, Tarr T, Nakken B, Szodoray P, Papp G
Front Immunol 2021;12:639975. Epub 2021 Mar 19 doi: 10.3389/fimmu.2021.639975. PMID: 33815392Free PMC Article

Therapy

Unveiling immunological signatures and predictors of response to immunosuppressive therapy in acquired aplastic anemia.
Gupta M, Shanmukhaiah C, Vundinti BR, Jose A, Tiwari S, Bhowmick A, Madkaikar M
Clin Exp Immunol 2024 Nov 12;218(3):291-299. doi: 10.1093/cei/uxae076. PMID: 39136361Free PMC Article
Associations between immune cell traits and autoimmune thyroid diseases: a bidirectional two-sample mendelian randomization study.
Cao Z, Huang J, Long X
Immunogenetics 2024 Aug;76(4):219-231. Epub 2024 Jun 28 doi: 10.1007/s00251-024-01345-9. PMID: 38940861
Comprehensive immunophenotypic analysis reveals the pathological involvement of Th17 cells in Graves' disease.
Torimoto K, Okada Y, Nakayamada S, Kubo S, Kurozumi A, Narisawa M, Tanaka Y
Sci Rep 2022 Oct 7;12(1):16880. doi: 10.1038/s41598-022-19556-z. PMID: 36207336Free PMC Article
Abnormal Shift in B Memory Cell Profile Is Associated With the Expansion of Circulating T Follicular Helper Cells via ICOS Signaling During Acute HIV-1 Infection.
Lu X, Zhang X, Cheung AKL, Moog C, Xia H, Li Z, Wang R, Ji Y, Xia W, Liu Z, Yuan L, Wang X, Wu H, Zhang T, Su B
Front Immunol 2022;13:837921. Epub 2022 Feb 10 doi: 10.3389/fimmu.2022.837921. PMID: 35222430Free PMC Article
Efficacy of tocilizumab therapy in a patient with severe pancytopenia associated with a STAT3 gain-of-function mutation.
Wang W, Liu L, Hui X, Wang Y, Ying W, Zhou Q, Hou J, Yang M, Sun B, Sun J, Wang X
BMC Immunol 2021 Mar 17;22(1):19. doi: 10.1186/s12865-021-00411-1. PMID: 33731004Free PMC Article

Prognosis

The profile and prognostic significance of bone marrow T-cell differentiation subsets in adult AML at diagnosis.
Sun K, Shi ZY, Wang YZ, Xie DH, Liu YR, Jiang Q, Jiang H, Huang XJ, Qin YZ
Front Immunol 2024;15:1418792. Epub 2024 Jul 19 doi: 10.3389/fimmu.2024.1418792. PMID: 39100667Free PMC Article
Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus.
Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Regulatory T and B cells in transient hypogammaglobulinemia of infancy.
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Long-Term Follow-Up of Newborns with 22q11 Deletion Syndrome and Low TRECs.
Framme JL, Lundqvist C, Lundell AC, van Schouwenburg PA, Lemarquis AL, Thörn K, Lindgren S, Gudmundsdottir J, Lundberg V, Degerman S, Zetterström RH, Borte S, Hammarström L, Telemo E, Hultdin M, van der Burg M, Fasth A, Oskarsdóttir S, Ekwall O
J Clin Immunol 2022 Apr;42(3):618-633. Epub 2022 Jan 26 doi: 10.1007/s10875-021-01201-5. PMID: 35080750Free PMC Article

Clinical prediction guides

Human umbilical cord-derived mesenchymal stem cell transplantation improves the long COVID.
Tang Y, Zou X, Liu P, Dai Y, Wang S, Su X, Yu Y, Tang W, Zhou J, Li C, Mei H, Xiao N, Ou Y, Wang J, Lu G, Lin G, Cheng L
J Med Virol 2024 Jun;96(6):e29757. doi: 10.1002/jmv.29757. PMID: 38899432
Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Regulatory T and B cells in transient hypogammaglobulinemia of infancy.
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Abnormalities of bone marrow B cells and plasma cells in primary immune thrombocytopenia.
Yu TS, Wang HY, Zhao YJ, Yu YF, Hou Y, Liu S, Han PP, Ni XF, Ji XB, Peng J, Liu XG, Hou M
Blood Adv 2021 Oct 26;5(20):4087-4101. doi: 10.1182/bloodadvances.2020003860. PMID: 34507351Free PMC Article
CD8(+) T cell subpopulations and pro-inflammatory cytokines in neuromyelitis optica spectrum disorder.
Shi Z, Qiu Y, Zhao Z, Wen D, Chen H, Du Q, Zhang Y, Wang J, Yan C, Yang M, Zhou H
Ann Clin Transl Neurol 2021 Jan;8(1):43-53. Epub 2020 Nov 24 doi: 10.1002/acn3.51241. PMID: 33231379Free PMC Article

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