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Abnormal leukocyte morphology

MedGen UID:: 508852
•Concept ID:: C0152009
•: Finding

Synonym:	Abnormal leukocyte function
SNOMED CT:	Abnormal white blood cell (24827003); Abnormal leukocyte (24827003); White blood cell abnormality (134199001); White blood cell abnormality (24827003)

HPO:	HP:0001881

Definition

An abnormality of leukocytes. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal leukocyte morphology

Phenotypic abnormality
- Abnormality of the immune system
  - Abnormal immune system morphology
    - Abnormal cellular immune system morphology
      - Abnormal leukocyte morphology
        Abnormal leukocyte count
        Abnormal dendritic cell count
        Abnormal granulocyte count
        Abnormal basophil count
        Abnormal eosinophil count
        Abnormal neutrophil count
        Granulocytopenia
        Granulocytosis
        Abnormal lymphocyte count
        Abnormal B cell count
        Abnormal T cell count
        Infection-associated lymphopenia
        Lymphocytosis
        Lymphopenia
        Increased peripheral blast count
        Leukocytosis
        Leukemoid reaction
        Leukopenia
        Agranulocytosis
        Abnormal lymphocyte morphology
        Abnormal B cell morphology
        Abnormal plasma cell count
        Abnormal natural killer cell morphology
        Abnormal natural killer cell count
        Abnormal T cell morphology
        Abnormal alpha-beta T cell morphology
        Decreased FOXP3-expressing T cell count
        Decreased T-cell ZAP-70 protein expression in CD4-positive T cells
        Absent microvilli on the surface of peripheral blood lymphocytes
        Impaired lymphocyte transformation with phytohemagglutinin
        Plasmacytosis
        Vacuolated lymphocytes
        PAS-positive lymphocyte vacuolization
        Abnormal myeloid leukocyte morphology
        Abnormal granulocyte morphology
        Abnormal basophil morphology
        Abnormal eosinophil morphology
        Abnormal mast cell morphology
        Abnormality of neutrophils
        Abnormal macrophage morphology
        Abnormal macrophage count
        Bone-marrow foam cells
        Granulomatosis
        Hemophagocytosis
        Histiocytosis
        Michaelis-Gutmann bodies
        Sea-blue histiocyte syndrome
        Abnormal monocyte morphology
        Abnormal monocyte count

Professional guidelines

PubMed

Chronic myelomonocytic leukemia: 2024 update on diagnosis, risk stratification and management.

Patnaik MM, Tefferi A
Am J Hematol 2024 Jun;99(6):1142-1165. Epub 2024 Mar 7 doi: 10.1002/ajh.27271. PMID: 38450850 Free PMC Article

Primary and secondary defects of the thymus.

Dinges SS, Amini K, Notarangelo LD, Delmonte OM
Immunol Rev 2024 Mar;322(1):178-211. Epub 2024 Jan 16 doi: 10.1111/imr.13306. PMID: 38228406 Free PMC Article

Hyperleukocytosis and leukostasis: management of a medical emergency.

Giammarco S, Chiusolo P, Piccirillo N, Di Giovanni A, Metafuni E, Laurenti L, Sica S, Pagano L
Expert Rev Hematol 2017 Feb;10(2):147-154. Epub 2016 Dec 26 doi: 10.1080/17474086.2017.1270754. PMID: 27967252

See all (264)

Recent clinical studies

Etiology

Primary and secondary defects of the thymus.

Dinges SS, Amini K, Notarangelo LD, Delmonte OM
Immunol Rev 2024 Mar;322(1):178-211. Epub 2024 Jan 16 doi: 10.1111/imr.13306. PMID: 38228406 Free PMC Article

Computational analysis of peripheral blood smears detects disease-associated cytomorphologies.

de Almeida JG, Gudgin E, Besser M, Dunn WG, Cooper J, Haferlach T, Vassiliou GS, Gerstung M
Nat Commun 2023 Jul 20;14(1):4378. doi: 10.1038/s41467-023-39676-y. PMID: 37474506 Free PMC Article

Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Peripheral Mononuclear Cells in Patients With Ankylosing Spondylitis.

Xu H, Yu H, Liu L, Wu H, Zhang C, Cai W, Hong X, Liu D, Tang D, Dai Y
Front Immunol 2021;12:760381. Epub 2021 Nov 22 doi: 10.3389/fimmu.2021.760381. PMID: 34880858 Free PMC Article

Histopathology of laryngomalacia.

Gan RWC, Moustafa A, Turner K, Knight L
Acta Otolaryngol 2021 Jan;141(1):85-88. Epub 2020 Oct 14 doi: 10.1080/00016489.2020.1821246. PMID: 33393421

Role of Neutrophils in Psoriasis.

Wang WM, Jin HZ
J Immunol Res 2020;2020:3709749. Epub 2020 Jun 5 doi: 10.1155/2020/3709749. PMID: 32587871 Free PMC Article

See all (3204)

Diagnosis

Primary and secondary defects of the thymus.

Dinges SS, Amini K, Notarangelo LD, Delmonte OM
Immunol Rev 2024 Mar;322(1):178-211. Epub 2024 Jan 16 doi: 10.1111/imr.13306. PMID: 38228406 Free PMC Article

POEMS Syndrome: Diagnosis and Investigative Work-up.

Dispenzieri A, Kourelis T, Buadi F
Hematol Oncol Clin North Am 2018 Feb;32(1):119-139. doi: 10.1016/j.hoc.2017.09.010. PMID: 29157614

Nuclear medicine imaging of bone infections.

Love C, Palestro CJ
Clin Radiol 2016 Jul;71(7):632-46. Epub 2016 Feb 17 doi: 10.1016/j.crad.2016.01.003. PMID: 26897336

How to approach chronic anemia.

Koury MJ, Rhodes M
Hematology Am Soc Hematol Educ Program 2012;2012:183-90. doi: 10.1182/asheducation-2012.1.183. PMID: 23233579

Why does my patient have leukocytosis?

Cerny J, Rosmarin AG
Hematol Oncol Clin North Am 2012 Apr;26(2):303-19, viii. Epub 2012 Feb 17 doi: 10.1016/j.hoc.2012.01.001. PMID: 22463829

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Therapy

NK cell-based cancer immunotherapy: from basic biology to clinical development.

Liu S, Galat V, Galat Y, Lee YKA, Wainwright D, Wu J
J Hematol Oncol 2021 Jan 6;14(1):7. doi: 10.1186/s13045-020-01014-w. PMID: 33407739 Free PMC Article

Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia.

Wang J, Xu Y, Chen Z, Liang J, Lin Z, Liang H, Xu Y, Wu Q, Guo X, Nie J, Lu B, Huang B, Xian H, Wang X, Wu Q, Zeng J, Chai C, Zhang M, Lin Y, Zhang L, Zhao S, Tong Y, Zeng L, Gu X, Chen ZG, Yi S, Zhang T, Delfouneso D, Zhang Y, Nutt SL, Lew AM, Lu L, Bai F, Xia H, Wen Z, Zhang Y
Cell 2020 Dec 23;183(7):1867-1883.e26. Epub 2020 Nov 27 doi: 10.1016/j.cell.2020.10.048. PMID: 33248023

B Cell Abnormalities in Systemic Lupus Erythematosus and Lupus Nephritis-Role in Pathogenesis and Effect of Immunosuppressive Treatments.

Yap DYH, Chan TM
Int J Mol Sci 2019 Dec 10;20(24) doi: 10.3390/ijms20246231. PMID: 31835612 Free PMC Article

Biliary atresia: A comprehensive review.

Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637

Chediak-Higashi syndrome.

Barak Y, Nir E
Am J Pediatr Hematol Oncol 1987 Spring;9(1):42-55. doi: 10.1097/00043426-198721000-00008. PMID: 3296821

See all (2001)

Prognosis

Computational analysis of peripheral blood smears detects disease-associated cytomorphologies.

de Almeida JG, Gudgin E, Besser M, Dunn WG, Cooper J, Haferlach T, Vassiliou GS, Gerstung M
Nat Commun 2023 Jul 20;14(1):4378. doi: 10.1038/s41467-023-39676-y. PMID: 37474506 Free PMC Article

Neutropenia and leukemia development: genetic risk factors and prognosis.

Shahrabi S, Maleknia M, Tavakolifar Y, D Zayeri Z, Saki N
Leuk Lymphoma 2019 Dec;60(14):3363-3374. Epub 2019 Jun 19 doi: 10.1080/10428194.2019.1630622. PMID: 31213100

A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer.

Wagner J, Rapsomaniki MA, Chevrier S, Anzeneder T, Langwieder C, Dykgers A, Rees M, Ramaswamy A, Muenst S, Soysal SD, Jacobs A, Windhager J, Silina K, van den Broek M, Dedes KJ, Rodríguez Martínez M, Weber WP, Bodenmiller B
Cell 2019 May 16;177(5):1330-1345.e18. Epub 2019 Apr 11 doi: 10.1016/j.cell.2019.03.005. PMID: 30982598 Free PMC Article

Biliary atresia: A comprehensive review.

Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637

Peripheral T cell lymphoma in Asia.

Park S, Ko YH
Int J Hematol 2014 Mar;99(3):227-39. Epub 2014 Jan 31 doi: 10.1007/s12185-014-1520-3. PMID: 24481942

See all (2189)

Clinical prediction guides

Computational analysis of peripheral blood smears detects disease-associated cytomorphologies.

de Almeida JG, Gudgin E, Besser M, Dunn WG, Cooper J, Haferlach T, Vassiliou GS, Gerstung M
Nat Commun 2023 Jul 20;14(1):4378. doi: 10.1038/s41467-023-39676-y. PMID: 37474506 Free PMC Article

Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Peripheral Mononuclear Cells in Patients With Ankylosing Spondylitis.

Xu H, Yu H, Liu L, Wu H, Zhang C, Cai W, Hong X, Liu D, Tang D, Dai Y
Front Immunol 2021;12:760381. Epub 2021 Nov 22 doi: 10.3389/fimmu.2021.760381. PMID: 34880858 Free PMC Article

Artificial intelligence and leukocyte epigenomics: Evaluation and prediction of late-onset Alzheimer's disease.

Bahado-Singh RO, Vishweswaraiah S, Aydas B, Yilmaz A, Metpally RP, Carey DJ, Crist RC, Berrettini WH, Wilson GD, Imam K, Maddens M, Bisgin H, Graham SF, Radhakrishna U
PLoS One 2021;16(3):e0248375. Epub 2021 Mar 31 doi: 10.1371/journal.pone.0248375. PMID: 33788842 Free PMC Article

Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring.

Collins MH, Martin LJ, Alexander ES, Boyd JT, Sheridan R, He H, Pentiuk S, Putnam PE, Abonia JP, Mukkada VA, Franciosi JP, Rothenberg ME
Dis Esophagus 2017 Feb 1;30(3):1-8. doi: 10.1111/dote.12470. PMID: 26857345 Free PMC Article

Hematological complications of alcoholism.

Ballard HS
Alcohol Clin Exp Res 1989 Oct;13(5):706-20. doi: 10.1111/j.1530-0277.1989.tb00408.x. PMID: 2688472

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Recent systematic reviews

Single cell analysis in systemic sclerosis - A systematic review.

Fukasawa T, Yoshizaki-Ogawa A, Enomoto A, Yamashita T, Miyagawa K, Sato S, Yoshizaki A
Immunol Med 2024 Sep;47(3):118-129. Epub 2024 May 31 doi: 10.1080/25785826.2024.2360690. PMID: 38818750

Neutropenia in patients with hyperthyroidism: Systematic review and meta-analysis.

Scappaticcio L, Maiorino MI, Maio A, Esposito K, Bellastella G
Clin Endocrinol (Oxf) 2021 Mar;94(3):473-483. Epub 2020 Sep 1 doi: 10.1111/cen.14313. PMID: 32799342

Cellular models to study bipolar disorder: A systematic review.

Viswanath B, Jose SP, Squassina A, Thirthalli J, Purushottam M, Mukherjee O, Vladimirov V, Patrinos GP, Del Zompo M, Jain S
J Affect Disord 2015 Sep 15;184:36-50. Epub 2015 May 28 doi: 10.1016/j.jad.2015.05.037. PMID: 26070045

Variability in diagnostic criteria for eosinophilic esophagitis: a systematic review.

Dellon ES, Aderoju A, Woosley JT, Sandler RS, Shaheen NJ
Am J Gastroenterol 2007 Oct;102(10):2300-13. Epub 2007 Jul 7 doi: 10.1111/j.1572-0241.2007.01396.x. PMID: 17617209

The influence of diabetes on the periodontal tissues.

Ryan ME, Carnu O, Kamer A
J Am Dent Assoc 2003 Oct;134 Spec No:34S-40S. doi: 10.14219/jada.archive.2003.0370. PMID: 18196671

See all (17)

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Abnormal leukocyte morphology

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Genetic Testing Registry

Clinical resources

Practice guidelines

Consumer resources

Reviews

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