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Deep dermal perivascular inflammatory infiltrate

MedGen UID:
1611554
•Concept ID:
C4531289
•
Finding
Synonym: Deep perivascular inflammatory infiltrate
 
HPO: HP:0031191

Definition

Numerous lymphocytes surrounding blood vessels in the deep part of the dermis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDeep dermal perivascular inflammatory infiltrate

Conditions with this feature

Familial amyloid nephropathy with urticaria AND deafness
MedGen UID:
120634
•Concept ID:
C0268390
•
Disease or Syndrome
Muckle-Wells syndrome (MWS) is characterized by episodic skin rash, arthralgias, and fever associated with late-onset sensorineural deafness and renal amyloidosis (Dode et al., 2002).
See: Condition Record
Familial amyloid nephropathy with urticaria AND deafness

Professional guidelines

PubMed

Tumid lupus erythematosus: criteria for classification with immunohistochemical analysis.
Alexiades-Armenakas MR, Baldassano M, Bince B, Werth V, Bystryn JC, Kamino H, Soter NA, Franks AG Jr
Arthritis Rheum 2003 Aug 15;49(4):494-500. doi: 10.1002/art.11206. PMID: 12910555

Recent clinical studies

Etiology

Morphea after Silicone Implants.
Wollina U, Schönlebe J
Acta Dermatovenerol Croat 2023 Aug;31(1):45-47. PMID: 37843092
Idiopathic perniosis presenting as acral purpuric lesions: Clustering of cases before COVID-19 pandemic and their comparison with chilblain like lesions reported in the literature.
Jindal R, Chauhan P, Goyal D, Shirazi N
Dermatol Ther 2021 May;34(3):e14951. Epub 2021 Mar 27 doi: 10.1111/dth.14951. PMID: 33740317Free PMC Article
Histopathological Spectrum and Immunophenotypic Characterization of Symmetrical Drug-Related Intertriginous and Flexural Exanthema.
Muresan AM, Metze D, Böer-Auer A, Braun SA
Am J Dermatopathol 2021 Feb 1;43(2):103-111. doi: 10.1097/DAD.0000000000001722. PMID: 32618703
Angiolymphoid hyperplasia with eosinophilia treated with Mohs micrographic surgery.
Trivedi A, Norris I, DeWitt CM, Goldman GD
Dermatol Online J 2019 Dec 15;25(12) PMID: 32045167
Prolonged urticaria with purpura: the spectrum of clinical and histopathologic features in a prospective series of 22 patients exhibiting the clinical features of urticarial vasculitis.
Lee JS, Loh TH, Seow SC, Tan SH
J Am Acad Dermatol 2007 Jun;56(6):994-1005. doi: 10.1016/j.jaad.2006.10.962. PMID: 17504716

Diagnosis

Cutaneous erythematous lupus with acneiform presentation.
Caputo GC, Bartos CS, Pagliari C, Criado PR
Dermatol Online J 2023 Dec 15;29(6) doi: 10.5070/D329663001. PMID: 38478672
Morphea after Silicone Implants.
Wollina U, Schönlebe J
Acta Dermatovenerol Croat 2023 Aug;31(1):45-47. PMID: 37843092
Cutaneous Manifestations of Castleman Disease: Histopathological Characteristics and Review of Literature.
Zapata-Salazar NA, Gómez-Flores M, Ocampo-Candiani J, Chavez-Alvarez S
Am J Dermatopathol 2021 Dec 1;43(12):926-931. doi: 10.1097/DAD.0000000000001971. PMID: 33989215
Histopathological Spectrum and Immunophenotypic Characterization of Symmetrical Drug-Related Intertriginous and Flexural Exanthema.
Muresan AM, Metze D, Böer-Auer A, Braun SA
Am J Dermatopathol 2021 Feb 1;43(2):103-111. doi: 10.1097/DAD.0000000000001722. PMID: 32618703
Pityriasis Lichenoides: A Large Histopathological Case Series With a Focus on Adnexotropism.
Menzinger S, Frassati-Biaggi A, Leclerc-Mercier S, Bodemer C, Molina TJ, Fraitag S
Am J Dermatopathol 2020 Jan;42(1):1-10. doi: 10.1097/DAD.0000000000001448. PMID: 31880634

Therapy

Morphea after Silicone Implants.
Wollina U, Schönlebe J
Acta Dermatovenerol Croat 2023 Aug;31(1):45-47. PMID: 37843092
Imported fire ant envenomation: A clinicopathologic study of a recognizable form of arthropod assault reaction.
Villada G, Hafeez F, Ollague J, Nousari CH, Elgart GW
J Cutan Pathol 2017 Dec;44(12):1012-1017. Epub 2017 Sep 21 doi: 10.1111/cup.13036. PMID: 28873251
Prolonged urticaria with purpura: the spectrum of clinical and histopathologic features in a prospective series of 22 patients exhibiting the clinical features of urticarial vasculitis.
Lee JS, Loh TH, Seow SC, Tan SH
J Am Acad Dermatol 2007 Jun;56(6):994-1005. doi: 10.1016/j.jaad.2006.10.962. PMID: 17504716
Pseudoporphyria associated with Relafen therapy.
Magro CM, Crowson AN
J Cutan Pathol 1999 Jan;26(1):42-7. doi: 10.1111/j.1600-0560.1999.tb01789.x. PMID: 10189244
Studies on healing of Debrisan-treated wounds.
Jacobsson S, Jonsson L, Rank F, Rothman U
Scand J Plast Reconstr Surg 1976;10(2):97-101. doi: 10.3109/02844317609105196. PMID: 1019590

Prognosis

Histopathological Spectrum and Immunophenotypic Characterization of Symmetrical Drug-Related Intertriginous and Flexural Exanthema.
Muresan AM, Metze D, Böer-Auer A, Braun SA
Am J Dermatopathol 2021 Feb 1;43(2):103-111. doi: 10.1097/DAD.0000000000001722. PMID: 32618703
Sweet-like reaction due to arthropod bites: a histopathologic pitfall.
Battistella M, Bourrat E, Fardet L, Saada V, Janin A, Vignon-Pennamen MD
Am J Dermatopathol 2012 Jun;34(4):442-5. doi: 10.1097/DAD.0b013e3182313509. PMID: 22172958
Tumid lupus erythematosus: criteria for classification with immunohistochemical analysis.
Alexiades-Armenakas MR, Baldassano M, Bince B, Werth V, Bystryn JC, Kamino H, Soter NA, Franks AG Jr
Arthritis Rheum 2003 Aug 15;49(4):494-500. doi: 10.1002/art.11206. PMID: 12910555
Eosinophilic histiocytosis. Histopathology and immunohistochemistry.
Helton JL, Maize JC
Am J Dermatopathol 1996 Apr;18(2):111-7. doi: 10.1097/00000372-199604000-00002. PMID: 8739984
Cutaneous manifestations of the eosinophilia-myalgia syndrome.
Oursler JR, Farmer ER, Roubenoff R, Mogavero HS, Watson RM
Br J Dermatol 1992 Aug;127(2):138-46. doi: 10.1111/j.1365-2133.1992.tb08046.x. PMID: 1390142

Clinical prediction guides

Histopathological Spectrum and Immunophenotypic Characterization of Symmetrical Drug-Related Intertriginous and Flexural Exanthema.
Muresan AM, Metze D, Böer-Auer A, Braun SA
Am J Dermatopathol 2021 Feb 1;43(2):103-111. doi: 10.1097/DAD.0000000000001722. PMID: 32618703
Pityriasis Lichenoides: A Large Histopathological Case Series With a Focus on Adnexotropism.
Menzinger S, Frassati-Biaggi A, Leclerc-Mercier S, Bodemer C, Molina TJ, Fraitag S
Am J Dermatopathol 2020 Jan;42(1):1-10. doi: 10.1097/DAD.0000000000001448. PMID: 31880634
Sweet-like reaction due to arthropod bites: a histopathologic pitfall.
Battistella M, Bourrat E, Fardet L, Saada V, Janin A, Vignon-Pennamen MD
Am J Dermatopathol 2012 Jun;34(4):442-5. doi: 10.1097/DAD.0b013e3182313509. PMID: 22172958
Eosinophilic histiocytosis. Histopathology and immunohistochemistry.
Helton JL, Maize JC
Am J Dermatopathol 1996 Apr;18(2):111-7. doi: 10.1097/00000372-199604000-00002. PMID: 8739984
Studies on healing of Debrisan-treated wounds.
Jacobsson S, Jonsson L, Rank F, Rothman U
Scand J Plast Reconstr Surg 1976;10(2):97-101. doi: 10.3109/02844317609105196. PMID: 1019590

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