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Abnormal inflammatory response

MedGen UID:
868411
•Concept ID:
C4022805
•
Pathologic Function
HPO: HP:0012647

Definition

Any anomaly of the inflammatory response, a response to injury or infection characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal inflammatory response

Professional guidelines

PubMed

COPD and biologic treatment: state of the art.
Ferri S, Paoletti G, Pelaia C, Heffler E, Canonica GW, Puggioni F
Curr Opin Allergy Clin Immunol 2023 Aug 1;23(4):309-318. Epub 2023 Jun 20 doi: 10.1097/ACI.0000000000000920. PMID: 37357768
Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Pandit NG, Zaman M, Minkoff NZ, Tanner-Smith EE, Gomez-Duarte OG, Acra S, Nicholson MR
Cochrane Database Syst Rev 2023 Apr 25;4(4):CD012774. doi: 10.1002/14651858.CD012774.pub3. PMID: 37094824Free PMC Article
Chronic obstructive pulmonary disease - diagnosis and management of stable disease; a personalized approach to care, using the treatable traits concept based on clinical phenotypes. Position paper of the Czech Pneumological and Phthisiological Society.
Zatloukal J, Brat K, Neumannova K, Volakova E, Hejduk K, Kocova E, Kudela O, Kopecky M, Plutinsky M, Koblizek V
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2020 Dec;164(4):325-356. doi: 10.5507/bp.2020.056. PMID: 33325455

Recent clinical studies

Etiology

Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Pandit NG, Zaman M, Minkoff NZ, Tanner-Smith EE, Gomez-Duarte OG, Acra S, Nicholson MR
Cochrane Database Syst Rev 2023 Apr 25;4(4):CD012774. doi: 10.1002/14651858.CD012774.pub3. PMID: 37094824Free PMC Article
Pediatric sarcoidosis with diagnostic and therapeutical insights.
Sergi CM
Curr Opin Pulm Med 2021 Sep 1;27(5):472-477. doi: 10.1097/MCP.0000000000000814. PMID: 34397614
Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine.
Brandsma CA, Van den Berge M, Hackett TL, Brusselle G, Timens W
J Pathol 2020 Apr;250(5):624-635. Epub 2019 Dec 3 doi: 10.1002/path.5364. PMID: 31691283Free PMC Article
Copd.
McIvor RA, Tunks M, Todd DC
BMJ Clin Evid 2011 Jun 6;2011 PMID: 21639960Free PMC Article
Copd.
Kerstjens HA, Postma DS, Ten Hacken N
BMJ Clin Evid 2008 Dec 15;2008 PMID: 19445783Free PMC Article

Diagnosis

COPD and biologic treatment: state of the art.
Ferri S, Paoletti G, Pelaia C, Heffler E, Canonica GW, Puggioni F
Curr Opin Allergy Clin Immunol 2023 Aug 1;23(4):309-318. Epub 2023 Jun 20 doi: 10.1097/ACI.0000000000000920. PMID: 37357768
Pediatric sarcoidosis with diagnostic and therapeutical insights.
Sergi CM
Curr Opin Pulm Med 2021 Sep 1;27(5):472-477. doi: 10.1097/MCP.0000000000000814. PMID: 34397614
Chronic obstructive pulmonary disease - diagnosis and management of stable disease; a personalized approach to care, using the treatable traits concept based on clinical phenotypes. Position paper of the Czech Pneumological and Phthisiological Society.
Zatloukal J, Brat K, Neumannova K, Volakova E, Hejduk K, Kocova E, Kudela O, Kopecky M, Plutinsky M, Koblizek V
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2020 Dec;164(4):325-356. doi: 10.5507/bp.2020.056. PMID: 33325455
Nonesophageal Eosinophilic Gastrointestinal Disorders: Clinical Care and Future Directions.
Naramore S, Gupta SK
J Pediatr Gastroenterol Nutr 2018 Sep;67(3):318-321. doi: 10.1097/MPG.0000000000002040. PMID: 29851758Free PMC Article
Biomarkers in COPD.
Tzortzaki EG, Lambiri I, Vlachaki E, Siafakas NM
Curr Med Chem 2007;14(9):1037-48. doi: 10.2174/092986707780362943. PMID: 17439401

Therapy

Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway.
Yang Y, Tang X, Yao T, Zhang Y, Zhong Y, Wu S, Wang Y, Pan Z
Sci Rep 2024 Jan 16;14(1):1447. doi: 10.1038/s41598-024-51990-z. PMID: 38228655Free PMC Article
COPD and biologic treatment: state of the art.
Ferri S, Paoletti G, Pelaia C, Heffler E, Canonica GW, Puggioni F
Curr Opin Allergy Clin Immunol 2023 Aug 1;23(4):309-318. Epub 2023 Jun 20 doi: 10.1097/ACI.0000000000000920. PMID: 37357768
Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Pandit NG, Zaman M, Minkoff NZ, Tanner-Smith EE, Gomez-Duarte OG, Acra S, Nicholson MR
Cochrane Database Syst Rev 2023 Apr 25;4(4):CD012774. doi: 10.1002/14651858.CD012774.pub3. PMID: 37094824Free PMC Article
Vitamin D Modulates Intestinal Microbiota in Inflammatory Bowel Diseases.
Battistini C, Ballan R, Herkenhoff ME, Saad SMI, Sun J
Int J Mol Sci 2020 Dec 31;22(1) doi: 10.3390/ijms22010362. PMID: 33396382Free PMC Article
Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine.
Brandsma CA, Van den Berge M, Hackett TL, Brusselle G, Timens W
J Pathol 2020 Apr;250(5):624-635. Epub 2019 Dec 3 doi: 10.1002/path.5364. PMID: 31691283Free PMC Article

Prognosis

The prognostic value of systematic genetic screening in amyotrophic lateral sclerosis patients.
He D, Liu Y, Dong S, Shen D, Yang X, Hao M, Yin X, He X, Li Y, Wang Y, Liu M, Wang J, Chen X, Cui L
J Neurol 2024 Mar;271(3):1385-1396. Epub 2023 Nov 19 doi: 10.1007/s00415-023-12079-1. PMID: 37980296
Poly zinc finger protein ZFP14 suppresses lymphomagenesis and abnormal inflammatory response via the HOXA gene cluster.
Mohibi S, Chen M, Chen X, Zhang J
Biochim Biophys Acta Mol Basis Dis 2023 Jan 1;1869(1):166587. Epub 2022 Oct 28 doi: 10.1016/j.bbadis.2022.166587. PMID: 36349645Free PMC Article
Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review.
Maiese A, Scatena A, Costantino A, Chiti E, Occhipinti C, La Russa R, Di Paolo M, Turillazzi E, Frati P, Fineschi V
Int J Mol Sci 2022 Aug 19;23(16) doi: 10.3390/ijms23169354. PMID: 36012630Free PMC Article
The Role of IgG4 in Autoimmunity and Rheumatic Diseases.
Maslinska M, Dmowska-Chalaba J, Jakubaszek M
Front Immunol 2021;12:787422. Epub 2022 Jan 25 doi: 10.3389/fimmu.2021.787422. PMID: 35145508Free PMC Article
Chronic obstructive pulmonary disease - diagnosis and management of stable disease; a personalized approach to care, using the treatable traits concept based on clinical phenotypes. Position paper of the Czech Pneumological and Phthisiological Society.
Zatloukal J, Brat K, Neumannova K, Volakova E, Hejduk K, Kocova E, Kudela O, Kopecky M, Plutinsky M, Koblizek V
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2020 Dec;164(4):325-356. doi: 10.5507/bp.2020.056. PMID: 33325455

Clinical prediction guides

Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway.
Yang Y, Tang X, Yao T, Zhang Y, Zhong Y, Wu S, Wang Y, Pan Z
Sci Rep 2024 Jan 16;14(1):1447. doi: 10.1038/s41598-024-51990-z. PMID: 38228655Free PMC Article
Inflammation and vascular dysfunction: The negative synergistic combination of diabetes and COVID-19.
Bolla AM, Loretelli C, Montefusco L, Finzi G, Abdi R, Ben Nasr M, Lunati ME, Pastore I, Bonventre JV, Nebuloni M, Rusconi S, Santus P, Zuccotti G, Galli M, D'Addio F, Fiorina P
Diabetes Metab Res Rev 2022 Oct;38(7):e3565. Epub 2022 Jul 22 doi: 10.1002/dmrr.3565. PMID: 35830597Free PMC Article
Pediatric sarcoidosis with diagnostic and therapeutical insights.
Sergi CM
Curr Opin Pulm Med 2021 Sep 1;27(5):472-477. doi: 10.1097/MCP.0000000000000814. PMID: 34397614
Epidemiological and clinical aspects of Guillain-Barré syndrome and its variants.
Oliveira DRDCAB, Fernandez RNM, Grippe TC, Baião FS, Duarte RL, Fernandez DJ
Arq Neuropsiquiatr 2021 Jun;79(6):497-503. doi: 10.1590/0004-282X-ANP-2020-0314. PMID: 34320055Free PMC Article
Copd.
McIvor RA, Tunks M, Todd DC
BMJ Clin Evid 2011 Jun 6;2011 PMID: 21639960Free PMC Article

Recent systematic reviews

Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Pandit NG, Zaman M, Minkoff NZ, Tanner-Smith EE, Gomez-Duarte OG, Acra S, Nicholson MR
Cochrane Database Syst Rev 2023 Apr 25;4(4):CD012774. doi: 10.1002/14651858.CD012774.pub3. PMID: 37094824Free PMC Article
Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review.
Maiese A, Scatena A, Costantino A, Chiti E, Occhipinti C, La Russa R, Di Paolo M, Turillazzi E, Frati P, Fineschi V
Int J Mol Sci 2022 Aug 19;23(16) doi: 10.3390/ijms23169354. PMID: 36012630Free PMC Article
Copd.
McIvor RA, Tunks M, Todd DC
BMJ Clin Evid 2011 Jun 6;2011 PMID: 21639960Free PMC Article
Genome-wide transcription profiling of human sepsis: a systematic review.
Tang BM, Huang SJ, McLean AS
Crit Care 2010;14(6):R237. Epub 2010 Dec 29 doi: 10.1186/cc9392. PMID: 21190579Free PMC Article
Copd.
Kerstjens HA, Postma DS, Ten Hacken N
BMJ Clin Evid 2008 Dec 15;2008 PMID: 19445783Free PMC Article

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