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In Situ Mantle Cell Neoplasia

MedGen UID:
1613137
•Concept ID:
C4527429
•
Neoplastic Process
Synonyms: In Situ Mantle Cell Lymphoma; In situ mantle cell neoplasia; In Situ Mantle Cell Neoplasm
SNOMED CT: In situ mantle cell neoplasia (786860004)

Definition

A neoplastic lymphoid process characterized by the presence of cyclin D1 positive lymphoid cells, typically in the inner mantle zones of lymphoid tissue follicles, in cases that do not suggest the diagnosis of a mantle cell lymphoma. It is often found incidentally and has a low rate of progression. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIn Situ Mantle Cell Neoplasia

Professional guidelines

PubMed

Cytogenetics in the management of mature B-cell non-Hodgkin lymphomas: Guidelines from the Groupe Francophone de Cytogénétique Hematologique (GFCH).
Lefebvre C, Veronese L, Nadal N, Gaillard JB, Penther D, Daudignon A, Chauzeix J, Nguyen-Khac F, Chapiro E
Curr Res Transl Med 2023 Oct-Dec;71(4):103425. Epub 2023 Oct 23 doi: 10.1016/j.retram.2023.103425. PMID: 38016420
Ultrasensitive RNA In Situ Hybridization for Kappa and Lambda Light Chains Assists in the Differential Diagnosis of Nodular Lymphocyte-predominant Hodgkin Lymphoma.
Kaseb H, Wang Z, Cook JR
Am J Surg Pathol 2022 Aug 1;46(8):1078-1083. Epub 2022 Feb 24 doi: 10.1097/PAS.0000000000001881. PMID: 35195576
Mantle cell lymphoma: 2019 update on the diagnosis, pathogenesis, prognostication, and management.
Jain P, Wang M
Am J Hematol 2019 Jun;94(6):710-725. Epub 2019 Apr 19 doi: 10.1002/ajh.25487. PMID: 30963600

Recent clinical studies

Etiology

Lymphadenectomy Specimens in a Large Retrospective Cohort of Pediatric Patients Reveal No in situ Lymphomas but a Broad Spectrum of Reactive Changes.
Banz Y, Tzankov A, Dirnhofer S, Perren A, Hoeller S
Pathobiology 2017;84(3):139-143. Epub 2016 Nov 3 doi: 10.1159/000449253. PMID: 27806371

Diagnosis

Multifocal in situ mantle cell neoplasia of the ileocecal region: a case report with simultaneous nodal and extranodal involvement.
Joyon N, Kanaan C, Cotteret S, Sourrouille I, Scoazec JY, Dartigues P
Virchows Arch 2021 Nov;479(5):1037-1040. Epub 2021 Mar 1 doi: 10.1007/s00428-021-03065-x. PMID: 33650040
Early Events in Lymphoid Neoplasms and Indolent Follicular Lymphomas.
Perincheri S
Surg Pathol Clin 2019 Sep;12(3):719-731. Epub 2019 May 15 doi: 10.1016/j.path.2019.03.004. PMID: 31352984
Premalignant Clonal Hematopoietic Proliferations.
Nardi V, Kuo FC, Hasserjian RP
Am J Clin Pathol 2019 Aug 1;152(3):347-358. doi: 10.1093/ajcp/aqz079. PMID: 31305863
Follicular lymphoma with composite in situ mantle cell neoplasia.
Subtil A, Xu Z
Blood 2019 May 30;133(22):2460. doi: 10.1182/blood.2019000012. PMID: 31147376
In situ neoplasia in lymph node pathology.
Oishi N, Montes-Moreno S, Feldman AL
Semin Diagn Pathol 2018 Jan;35(1):76-83. Epub 2017 Nov 10 doi: 10.1053/j.semdp.2017.11.001. PMID: 29129357

Prognosis

Multifocal in situ mantle cell neoplasia of the ileocecal region: a case report with simultaneous nodal and extranodal involvement.
Joyon N, Kanaan C, Cotteret S, Sourrouille I, Scoazec JY, Dartigues P
Virchows Arch 2021 Nov;479(5):1037-1040. Epub 2021 Mar 1 doi: 10.1007/s00428-021-03065-x. PMID: 33650040
Early Events in Lymphoid Neoplasms and Indolent Follicular Lymphomas.
Perincheri S
Surg Pathol Clin 2019 Sep;12(3):719-731. Epub 2019 May 15 doi: 10.1016/j.path.2019.03.004. PMID: 31352984

Clinical prediction guides

Multifocal in situ mantle cell neoplasia of the ileocecal region: a case report with simultaneous nodal and extranodal involvement.
Joyon N, Kanaan C, Cotteret S, Sourrouille I, Scoazec JY, Dartigues P
Virchows Arch 2021 Nov;479(5):1037-1040. Epub 2021 Mar 1 doi: 10.1007/s00428-021-03065-x. PMID: 33650040
Lymphadenectomy Specimens in a Large Retrospective Cohort of Pediatric Patients Reveal No in situ Lymphomas but a Broad Spectrum of Reactive Changes.
Banz Y, Tzankov A, Dirnhofer S, Perren A, Hoeller S
Pathobiology 2017;84(3):139-143. Epub 2016 Nov 3 doi: 10.1159/000449253. PMID: 27806371

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