U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Increased CD4:CD8 ratio

MedGen UID:
1614673
•Concept ID:
C0920173
•
Finding
Synonyms: Increased CD4+/CD8+ ratio; Increased CD4+:CD8+ ratio
 
HPO: HP:0033221

Definition

An abnormal elevation of the relative proportion of CD4+ to CD8+ T cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased CD4:CD8 ratio

Conditions with this feature

Autoimmune disease, multisystem, infantile-onset, 2
MedGen UID:
934735
•Concept ID:
C4310768
•
Disease or Syndrome
Any autoimmune disease, multisystem, infantile-onset in which the cause of the disease is a mutation in the ZAP70 gene.
See: Condition Record
Proteasome-associated autoinflammatory syndrome 2
MedGen UID:
1648482
•Concept ID:
C4747989
•
Disease or Syndrome
Proteasome-associated autoinflammatory syndrome-2 (PRAAS2) is an autosomal dominant disorder with onset in early infancy. Affected individuals develop severe inflammatory neutrophilic dermatitis, autoimmunity, and variable immunodeficiency (summary by Poli et al., 2018). For a discussion of genetic heterogeneity of PRAAS, see PRAAS1 (256040).
See: Condition Record
Autoimmune disease, multisystem, infantile-onset, 2
Proteasome-associated autoinflammatory syndrome 2

Professional guidelines

PubMed

A retrospective clinical study of dolutegravir- versus efavirenz-based regimen in treatment-naïve patients with advanced HIV infection in Nanjing, China.
Zhong M, Li M, Qi M, Su Y, Yu N, Lv R, Ye Z, Zhang X, Xu X, Cheng C, Chen C, Wei H
Front Immunol 2022;13:1033098. Epub 2023 Jan 9 doi: 10.3389/fimmu.2022.1033098. PMID: 36700216Free PMC Article
CD4/CD8 ratio improvement in HIV-1-infected patients receiving dual antiretroviral treatment.
Monsalvo M, Vallejo A, Fontecha M, Vivancos MJ, Vizcarra P, Casado JL
Int J STD AIDS 2019 Jun;30(7):656-662. Epub 2019 Apr 8 doi: 10.1177/0956462419834129. PMID: 30961467
Telbivudine in the treatment of hepatitis B-associated cryoglobulinemia.
Boglione L, D'Avolio A, Cariti G, Di Perri G
J Clin Virol 2013 Feb;56(2):167-9. Epub 2012 Nov 20 doi: 10.1016/j.jcv.2012.10.014. PMID: 23182457

Recent clinical studies

Etiology

Probiotics to HIV-Infected Immunological Nonresponders: Altered Mucosal Immunity and Microbial Diversity Restricted to Ileum.
Meyer-Myklestad MH, Medhus AW, Stiksrud B, Lorvik KB, Seljeflot I, Hansen SH, Holm K, Hov JR, Kvale D, Dyrhol-Riise AM, Kummen M, Trøseid M, Reikvam DH
J Acquir Immune Defic Syndr 2022 Jan 1;89(1):77-86. doi: 10.1097/QAI.0000000000002817. PMID: 34878437
Increased CD4 : CD8 ratio normalization with implementation of current ART management guidelines.
Zhabokritsky A, Szadkowski L, Cooper C, Loutfy M, Wong A, McClean A, Hogg RS, Walmsley SL; Canadian Observational Cohort (CANOC) Collaboration
J Antimicrob Chemother 2021 Feb 11;76(3):729-737. doi: 10.1093/jac/dkaa484. PMID: 33249444Free PMC Article
Immune Abnormalities in Patients With Single Ventricle Circulation Precede the Fontan Procedure.
Kovacikova L, Krasnanova V, Skrak P, Zahorec M, Kantorova A, Semberova J, Bacharova L
World J Pediatr Congenit Heart Surg 2017 Nov;8(6):672-682. doi: 10.1177/2150135117732529. PMID: 29187105
Effects of cyanocobalamin on immunity in patients with pernicious anemia.
Erkurt MA, Aydogdu I, Dikilitaş M, Kuku I, Kaya E, Bayraktar N, Ozhan O, Ozkan I, Sonmez A
Med Princ Pract 2008;17(2):131-5. Epub 2008 Feb 19 doi: 10.1159/000112967. PMID: 18287797
Bronchoalveolar lavage in rheumatoid arthritis.
Kolarz G, Scherak O, Popp W, Ritschka L, Thumb N, Wottawa A, Zwick H
Br J Rheumatol 1993 Jul;32(7):556-61. doi: 10.1093/rheumatology/32.7.556. PMID: 8339125

Diagnosis

Folliculotropic Mycosis Fungoides In A Child: A Rare Case.
Zahoor F, Junaid S, Afzal G
J Pak Med Assoc 2023 Nov;73(11):2260-2262. doi: 10.47391/JPMA.8348. PMID: 38013542
Pulmonary sarcoid-like granulomatosis induced by nivolumab.
Montaudié H, Pradelli J, Passeron T, Lacour JP, Leroy S
Br J Dermatol 2017 Apr;176(4):1060-1063. Epub 2016 Dec 19 doi: 10.1111/bjd.14808. PMID: 27291635
BAL fluid cells in newly diagnosed pulmonary sarcoidosis with different clinical activity.
Danila E, Jurgauskiene L, Norkuniene J, Malickaite R
Ups J Med Sci 2009;114(1):26-31. doi: 10.1080/03009730802579729. PMID: 19242869Free PMC Article
Sex-specific manifestations of Löfgren's syndrome.
Grunewald J, Eklund A
Am J Respir Crit Care Med 2007 Jan 1;175(1):40-4. Epub 2006 Oct 5 doi: 10.1164/rccm.200608-1197OC. PMID: 17023727Free PMC Article
Bronchoalveolar lavage in rheumatoid arthritis.
Kolarz G, Scherak O, Popp W, Ritschka L, Thumb N, Wottawa A, Zwick H
Br J Rheumatol 1993 Jul;32(7):556-61. doi: 10.1093/rheumatology/32.7.556. PMID: 8339125

Therapy

CD4+/CD8+ improvement after switch from a second-generation integrase inhibitor regimen to long-acting cabotegravir and rilpivirine.
Muccini C, Gianotti N, Lolatto R, Nozza S, Diotallevi S, Castagna A
AIDS 2024 Nov 1;38(13):1890-1892. Epub 2024 Sep 26 doi: 10.1097/QAD.0000000000003984. PMID: 39325006
Increased CD4 : CD8 ratio normalization with implementation of current ART management guidelines.
Zhabokritsky A, Szadkowski L, Cooper C, Loutfy M, Wong A, McClean A, Hogg RS, Walmsley SL; Canadian Observational Cohort (CANOC) Collaboration
J Antimicrob Chemother 2021 Feb 11;76(3):729-737. doi: 10.1093/jac/dkaa484. PMID: 33249444Free PMC Article
Pulmonary sarcoid-like granulomatosis induced by nivolumab.
Montaudié H, Pradelli J, Passeron T, Lacour JP, Leroy S
Br J Dermatol 2017 Apr;176(4):1060-1063. Epub 2016 Dec 19 doi: 10.1111/bjd.14808. PMID: 27291635
Antiretroviral therapy in HIV-infected elite controllers: impact on gut immunology, microbial translocation, and biomarkers of serious non-AIDS conditions.
Kim CJ, Kovacs C, Chun TW, Kandel G, Osborne BJ, Huibner S, Shahabi K, Yue FY, Benko E, Ostowski M, Kaul R
J Acquir Immune Defic Syndr 2014 Dec 15;67(5):514-8. doi: 10.1097/QAI.0000000000000359. PMID: 25393939Free PMC Article
Can the CD4+/CD8+ ratio predict the outcome of interferon-alpha therapy for renal cell carcinoma?
Hernberg M, Muhonen T, Pyrhönen S
Ann Oncol 1997 Jan;8(1):71-7. doi: 10.1023/a:1008293117223. PMID: 9093710

Prognosis

Pulmonary sarcoid-like granulomatosis induced by nivolumab.
Montaudié H, Pradelli J, Passeron T, Lacour JP, Leroy S
Br J Dermatol 2017 Apr;176(4):1060-1063. Epub 2016 Dec 19 doi: 10.1111/bjd.14808. PMID: 27291635
Immune cells and prognosis in HPV-associated oropharyngeal squamous cell carcinomas: Review of the literature.
Saber CN, Grønhøj Larsen C, Dalianis T, von Buchwald C
Oral Oncol 2016 Jul;58:8-13. Epub 2016 May 7 doi: 10.1016/j.oraloncology.2016.04.004. PMID: 27311396
Antiretroviral therapy in HIV-infected elite controllers: impact on gut immunology, microbial translocation, and biomarkers of serious non-AIDS conditions.
Kim CJ, Kovacs C, Chun TW, Kandel G, Osborne BJ, Huibner S, Shahabi K, Yue FY, Benko E, Ostowski M, Kaul R
J Acquir Immune Defic Syndr 2014 Dec 15;67(5):514-8. doi: 10.1097/QAI.0000000000000359. PMID: 25393939Free PMC Article
Unfavorable clinical implications of circulating CD44+ lymphocytes in patients with nasopharyngeal carcinoma undergoing radiochemotherapy.
Hu FJ, Ge MH, Li P, Wang CC, Ling YT, Mao WM, Ling ZQ
Clin Chim Acta 2012 Jan 18;413(1-2):213-8. Epub 2011 Sep 29 doi: 10.1016/j.cca.2011.09.026. PMID: 21983162
T-cell markers in tumor-infiltrating lymphocytes of head and neck cancer.
Snyderman CH, Heo DS, Chen K, Whiteside TL, Johnson JT
Head Neck 1989 Jul-Aug;11(4):331-6. doi: 10.1002/hed.2880110408. PMID: 2502505

Clinical prediction guides

CD4+/CD8+ improvement after switch from a second-generation integrase inhibitor regimen to long-acting cabotegravir and rilpivirine.
Muccini C, Gianotti N, Lolatto R, Nozza S, Diotallevi S, Castagna A
AIDS 2024 Nov 1;38(13):1890-1892. Epub 2024 Sep 26 doi: 10.1097/QAD.0000000000003984. PMID: 39325006
Impact of switching to raltegravir and/or adding losartan in lymphoid tissue fibrosis and inflammation in people living with HIV. A randomized clinical trial.
Torres B, Guardo AC, Squarcia M, Diaz A, Fabra A, Caballero M, Ugarte A, Leal L, Gatell JM, Plana M, Garcia F
HIV Med 2021 Sep;22(8):674-681. Epub 2021 Jul 20 doi: 10.1111/hiv.13114. PMID: 34288357
Increased CD4 : CD8 ratio normalization with implementation of current ART management guidelines.
Zhabokritsky A, Szadkowski L, Cooper C, Loutfy M, Wong A, McClean A, Hogg RS, Walmsley SL; Canadian Observational Cohort (CANOC) Collaboration
J Antimicrob Chemother 2021 Feb 11;76(3):729-737. doi: 10.1093/jac/dkaa484. PMID: 33249444Free PMC Article
Immune Abnormalities in Patients With Single Ventricle Circulation Precede the Fontan Procedure.
Kovacikova L, Krasnanova V, Skrak P, Zahorec M, Kantorova A, Semberova J, Bacharova L
World J Pediatr Congenit Heart Surg 2017 Nov;8(6):672-682. doi: 10.1177/2150135117732529. PMID: 29187105
Common variants of T-cells contribute differently to phenotypic variation in sarcoidosis.
Rivera NV, Hagemann-Jensen M, Ferreira MAR, Kullberg S, Eklund A, Martin NG, Padyukov L, Grunewald J
Sci Rep 2017 Jul 17;7(1):5623. doi: 10.1038/s41598-017-05754-7. PMID: 28717140Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...