Gingival fibromatosis-5 (GINGF5) is an autosomal dominant benign overgrowth disorder characterized by slowly progressive fibrous enlargement of the keratinized gingival tissues. Affected individuals may have diastema, malposition of the teeth, and prolonged retention of primary teeth. Onset is in the first decade. Treatment by surgical resection is generally followed by regrowth of the gingival tissues (summary by Pehlivan et al., 2009).
For a general phenotypic description and a discussion of genetic heterogeneity of hereditary gingival fibromatosis, see GINGF1 (135300). [from
OMIM]