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Acquired Macrocephaly

MedGen UID:
164085
Concept ID:
C0877523
Disease or Syndrome
Synonyms: Acquired Megacephaly; Acquired Megalocephaly

Definition

A non-congenital condition in which the head circumference is two standard deviations greater than the mean. Causes include infection, intraventricular hemorrhage, subdural hematoma, and arachnoid cysts. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Aldana PR, Beier AD, Ranalli NJ, Sisk B, Ragheb JR
Clin Pediatr (Phila) 2020 Sep;59(9-10):902-909. Epub 2020 May 30 doi: 10.1177/0009922820928060. PMID: 32475161

Recent clinical studies

Etiology

Lai D, Gade M, Yang E, Koh HY, Lu J, Walley NM, Buckley AF, Sands TT, Akman CI, Mikati MA, McKhann GM, Goldman JE, Canoll P, Alexander AL, Park KL, Von Allmen GK, Rodziyevska O, Bhattacharjee MB, Lidov HGW, Vogel H, Grant GA, Porter BE, Poduri AH, Crino PB, Heinzen EL
Brain 2022 Aug 27;145(8):2704-2720. doi: 10.1093/brain/awac117. PMID: 35441233Free PMC Article
Leonard CG, Ranguis S, Lynn Cushing S, Blaser S, James A
J Int Adv Otol 2022 Mar;18(2):139-144. doi: 10.5152/iao.2022.21309. PMID: 35418362Free PMC Article
Epilepsy Phenome/Genome Project, Epi4K Consortium
Epilepsia 2021 Apr;62(4):973-983. Epub 2021 Apr 5 doi: 10.1111/epi.16854. PMID: 33818783Free PMC Article
Hollink IHIM, van den Ouweland AMW, Beverloo HB, Arentsen-Peters STCJM, Zwaan CM, Wagner A
J Med Genet 2017 Dec;54(12):805-808. Epub 2017 Apr 21 doi: 10.1136/jmedgenet-2017-104574. PMID: 28432085
Leviton A, Gilles F
Pediatr Neurol 1996 Sep;15(2):127-36. doi: 10.1016/0887-8994(96)00157-9. PMID: 8888047

Diagnosis

Lazea C, Vulturar R, Chiș A, Encica S, Horvat M, Belizna C, Damian LO
Int J Mol Sci 2024 May 20;25(10) doi: 10.3390/ijms25105567. PMID: 38791606Free PMC Article
Epilepsy Phenome/Genome Project, Epi4K Consortium
Epilepsia 2021 Apr;62(4):973-983. Epub 2021 Apr 5 doi: 10.1111/epi.16854. PMID: 33818783Free PMC Article
Jansen AC, Keymolen K
Handb Clin Neurol 2019;162:105-132. doi: 10.1016/B978-0-444-64029-1.00005-9. PMID: 31324307
Tan AP, Mankad K, Gonçalves FG, Talenti G, Alexia E
Top Magn Reson Imaging 2018 Aug;27(4):197-217. doi: 10.1097/RMR.0000000000000170. PMID: 30086108
Kahle KT, Kulkarni AV, Limbrick DD Jr, Warf BC
Lancet 2016 Feb 20;387(10020):788-99. Epub 2015 Aug 6 doi: 10.1016/S0140-6736(15)60694-8. PMID: 26256071

Therapy

Ostendorf AP, Wong M
CNS Drugs 2015 Feb;29(2):91-9. doi: 10.1007/s40263-014-0223-x. PMID: 25633849Free PMC Article
Galanopoulou AS, Gorter JA, Cepeda C
Epilepsia 2012 Jul;53(7):1119-30. Epub 2012 May 11 doi: 10.1111/j.1528-1167.2012.03506.x. PMID: 22578218Free PMC Article
Riffaud L, Moughty C, Henaux PL, Haegelen C, Morandi X
Pediatr Neurosurg 2008;44(3):229-33. Epub 2008 Mar 20 doi: 10.1159/000121381. PMID: 18354264
Durán-McKinster C, Moises C, Rodríguez-Jurado R, Tamayo-Sánchez L, Orozco-Covarrubias L, Ruiz-Maldonado R
Pediatr Dermatol 2002 Sep-Oct;19(5):423-5. doi: 10.1046/j.1525-1470.2002.00119.x. PMID: 12383100

Prognosis

Joung J, Gallison K, Sollee JJ, Vigilante N, Cooper H, Liu GW, Ballester L, Faig W, Waldman AT
J Child Neurol 2023 Dec;38(13-14):672-678. Epub 2023 Nov 3 doi: 10.1177/08830738231210040. PMID: 37920915
Kölker S, Valayannopoulos V, Burlina AB, Sykut-Cegielska J, Wijburg FA, Teles EL, Zeman J, Dionisi-Vici C, Barić I, Karall D, Arnoux JB, Avram P, Baumgartner MR, Blasco-Alonso J, Boy SP, Rasmussen MB, Burgard P, Chabrol B, Chakrapani A, Chapman K, Cortès I Saladelafont E, Couce ML, de Meirleir L, Dobbelaere D, Furlan F, Gleich F, González MJ, Gradowska W, Grünewald S, Honzik T, Hörster F, Ioannou H, Jalan A, Häberle J, Haege G, Langereis E, de Lonlay P, Martinelli D, Matsumoto S, Mühlhausen C, Murphy E, de Baulny HO, Ortez C, Pedrón CC, Pintos-Morell G, Pena-Quintana L, Ramadža DP, Rodrigues E, Scholl-Bürgi S, Sokal E, Summar ML, Thompson N, Vara R, Pinera IV, Walter JH, Williams M, Lund AM, Garcia-Cazorla A
J Inherit Metab Dis 2015 Nov;38(6):1059-74. Epub 2015 Apr 15 doi: 10.1007/s10545-015-9840-x. PMID: 25875216
Leviton A, Gilles F
Pediatr Neurol 1996 Sep;15(2):127-36. doi: 10.1016/0887-8994(96)00157-9. PMID: 8888047
Rapin I, Mattis S, Rowan AJ, Golden GG
Dev Med Child Neurol 1977 Apr;19(2):197-207. PMID: 870358

Clinical prediction guides

Lazea C, Vulturar R, Chiș A, Encica S, Horvat M, Belizna C, Damian LO
Int J Mol Sci 2024 May 20;25(10) doi: 10.3390/ijms25105567. PMID: 38791606Free PMC Article
Joung J, Gallison K, Sollee JJ, Vigilante N, Cooper H, Liu GW, Ballester L, Faig W, Waldman AT
J Child Neurol 2023 Dec;38(13-14):672-678. Epub 2023 Nov 3 doi: 10.1177/08830738231210040. PMID: 37920915
Berland S, Jareld J, Hickson N, Schlecht H, Houge G, Douzgou S
Cold Spring Harb Mol Case Stud 2021 Dec;7(6) Epub 2021 Dec 9 doi: 10.1101/mcs.a006121. PMID: 34887308Free PMC Article
Kölker S, Valayannopoulos V, Burlina AB, Sykut-Cegielska J, Wijburg FA, Teles EL, Zeman J, Dionisi-Vici C, Barić I, Karall D, Arnoux JB, Avram P, Baumgartner MR, Blasco-Alonso J, Boy SP, Rasmussen MB, Burgard P, Chabrol B, Chakrapani A, Chapman K, Cortès I Saladelafont E, Couce ML, de Meirleir L, Dobbelaere D, Furlan F, Gleich F, González MJ, Gradowska W, Grünewald S, Honzik T, Hörster F, Ioannou H, Jalan A, Häberle J, Haege G, Langereis E, de Lonlay P, Martinelli D, Matsumoto S, Mühlhausen C, Murphy E, de Baulny HO, Ortez C, Pedrón CC, Pintos-Morell G, Pena-Quintana L, Ramadža DP, Rodrigues E, Scholl-Bürgi S, Sokal E, Summar ML, Thompson N, Vara R, Pinera IV, Walter JH, Williams M, Lund AM, Garcia-Cazorla A
J Inherit Metab Dis 2015 Nov;38(6):1059-74. Epub 2015 Apr 15 doi: 10.1007/s10545-015-9840-x. PMID: 25875216
Galanopoulou AS, Gorter JA, Cepeda C
Epilepsia 2012 Jul;53(7):1119-30. Epub 2012 May 11 doi: 10.1111/j.1528-1167.2012.03506.x. PMID: 22578218Free PMC Article

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