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Advanced Hypopharyngeal Squamous Cell Carcinoma

MedGen UID:
1654832
•Concept ID:
C4727686
•
Neoplastic Process
Synonym: Advanced Squamous Cell Carcinoma of the Hypopharynx

Definition

A squamous cell carcinoma of the hypopharynx that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Hypopharyngeal Squamous Cell Carcinoma

Professional guidelines

PubMed

Distinct Failure Patterns in Hypopharyngeal Cancer Patients Receiving Surgery-Based Versus Radiation-Based Treatment.
Lin YH, Hsiao JR, Wu YH, Chang JS, Ou CY, Lee WT, Huang CC, Chang CC, Lai YH, Tsai ST, Hsueh WT, Yen CJ, Lin CL, Chen YS, Jiang SS, Su YC, Wu SY
Ann Surg Oncol 2023 Feb;30(2):1169-1181. Epub 2022 Nov 6 doi: 10.1245/s10434-022-12744-1. PMID: 36336733Free PMC Article
Is Increased Time From Diagnosis to Treatment in Advanced Hypopharynx Cancer Associated With Poorer Outcomes: A Single-Centre Analysis.
Santos M, Monteiro E
Ear Nose Throat J 2021 Jul;100(6):454-459. Epub 2019 Sep 30 doi: 10.1177/0145561319878926. PMID: 31569981
Treatment patterns and survival outcomes of advanced hypopharyngeal squamous cell carcinoma.
Tsai YT, Chen WC, Chien CY, Hsu CM, Lee YC, Tsai MS, Lin MH, Lai CH, Chang KP
World J Surg Oncol 2020 May 1;18(1):82. doi: 10.1186/s12957-020-01866-z. PMID: 32357934Free PMC Article

Recent clinical studies

Etiology

Induction chemotherapy of modified docetaxel, cisplatin, 5-fluorouracil for laryngeal preservation in locally advanced hypopharyngeal squamous cell carcinoma.
Li R, Ye L, Zhu Y, Ding H, Wang S, Ying H, Wu C, Zhou L, Wang X, Tian S
Head Neck 2022 Sep;44(9):2018-2029. doi: 10.1002/hed.27119. PMID: 35915867
Nomograms predicting prognosis for locally advanced hypopharyngeal squamous cell carcinoma.
Yang H, Zeng M, Cao S, Jin L
Eur Arch Otorhinolaryngol 2022 Jun;279(6):3041-3052. Epub 2021 Oct 14 doi: 10.1007/s00405-021-07109-5. PMID: 34648051
Presurgical platelet-lymphocyte ratio for prognosis in advanced hypopharyngeal squamous cell carcinoma in individuals undergoing radical resection.
Chen H, Song S, Li A, Ma D, Lin C, Qian X, Gao X, Shen X
Acta Otolaryngol 2021 May;141(5):537-543. Epub 2021 Apr 19 doi: 10.1080/00016489.2021.1891456. PMID: 33872102
Utility of Esophagrams to Detect Prevertebral Invasion in Hypopharyngeal Squamous Cell Carcinoma.
Kaffenberger TM, Eichar B, Traylor KS, Kubik MW, Branstetter BF 4th
Laryngoscope 2021 Apr;131(4):800-805. Epub 2020 Aug 17 doi: 10.1002/lary.29011. PMID: 33270244
Treatment patterns and survival outcomes of advanced hypopharyngeal squamous cell carcinoma.
Tsai YT, Chen WC, Chien CY, Hsu CM, Lee YC, Tsai MS, Lin MH, Lai CH, Chang KP
World J Surg Oncol 2020 May 1;18(1):82. doi: 10.1186/s12957-020-01866-z. PMID: 32357934Free PMC Article

Diagnosis

Oncological outcomes from surgical vs. non-surgical treatments for advanced hypopharyngeal squamous cell carcinoma: a surveillance, epidemiology, and end results-based study.
Fan Y, Li S, Xia X, Yu S, Zhu X, Zhu Y, Diao W, Chen X
Clin Transl Oncol 2022 Dec;24(12):2379-2387. Epub 2022 Jul 27 doi: 10.1007/s12094-022-02890-z. PMID: 35882729
Presurgical platelet-lymphocyte ratio for prognosis in advanced hypopharyngeal squamous cell carcinoma in individuals undergoing radical resection.
Chen H, Song S, Li A, Ma D, Lin C, Qian X, Gao X, Shen X
Acta Otolaryngol 2021 May;141(5):537-543. Epub 2021 Apr 19 doi: 10.1080/00016489.2021.1891456. PMID: 33872102
Utility of Esophagrams to Detect Prevertebral Invasion in Hypopharyngeal Squamous Cell Carcinoma.
Kaffenberger TM, Eichar B, Traylor KS, Kubik MW, Branstetter BF 4th
Laryngoscope 2021 Apr;131(4):800-805. Epub 2020 Aug 17 doi: 10.1002/lary.29011. PMID: 33270244
Prognostic values of preoperative platelet-to-lymphocyte ratio and platelet-related indices in advanced hypopharyngeal squamous cell carcinoma.
Lau HC, Hsueh CY, Chen Q, Tao L, Zhou L, Deng W, Zhang M
Clin Otolaryngol 2020 Mar;45(2):221-230. Epub 2020 Jan 3 doi: 10.1111/coa.13497. PMID: 31850682
Fibrinogen and Neutrophil-to-lymphocyte Ratio Predicts Survival in Patients with Advanced Hypopharyngeal Squamous Cell Carcinoma.
Kuwahara T, Takahashi H, Sano D, Matsuoka M, Hyakusoku H, Hatano T, Hiiragi Y, Oridate N
Anticancer Res 2018 Sep;38(9):5321-5330. doi: 10.21873/anticanres.12859. PMID: 30194184

Therapy

Induction chemotherapy of modified docetaxel, cisplatin, 5-fluorouracil for laryngeal preservation in locally advanced hypopharyngeal squamous cell carcinoma.
Li R, Ye L, Zhu Y, Ding H, Wang S, Ying H, Wu C, Zhou L, Wang X, Tian S
Head Neck 2022 Sep;44(9):2018-2029. doi: 10.1002/hed.27119. PMID: 35915867
Nomograms predicting prognosis for locally advanced hypopharyngeal squamous cell carcinoma.
Yang H, Zeng M, Cao S, Jin L
Eur Arch Otorhinolaryngol 2022 Jun;279(6):3041-3052. Epub 2021 Oct 14 doi: 10.1007/s00405-021-07109-5. PMID: 34648051
Patterns of regional lymph node failure of locally advanced hypopharyngeal squamous cell carcinoma after first-line treatment with surgery and/or intensity-modulated radiotherapy.
Wang D, Yu S, Zhai L, Xu J, Li B
BMC Cancer 2020 Apr 6;20(1):283. doi: 10.1186/s12885-020-06793-6. PMID: 32252691Free PMC Article
Definitive Chemoradiation in Locally Advanced Squamous Cell Carcinoma of the Hypopharynx: Long-term Outcomes and Toxicity.
Juloori A, Koyfman SA, Geiger JL, Joshi NP, Woody NM, Burkey BB, Scharpf J, Lamarre EL, Prendes B, Adelstein DJ, Greskovich JF, Keller L
Anticancer Res 2018 Jun;38(6):3543-3549. doi: 10.21873/anticanres.12626. PMID: 29848708
Prognostic factors in patients with advanced hypopharyngeal squamous cell carcinoma treated with concurrent chemoradiotherapy.
Krstevska V, Stojkovski I, Zafirova-Ivanovska B, Crvenkova S
J BUON 2012 Apr-Jun;17(2):327-36. PMID: 22740214

Prognosis

Nomograms predicting prognosis for locally advanced hypopharyngeal squamous cell carcinoma.
Yang H, Zeng M, Cao S, Jin L
Eur Arch Otorhinolaryngol 2022 Jun;279(6):3041-3052. Epub 2021 Oct 14 doi: 10.1007/s00405-021-07109-5. PMID: 34648051
Presurgical platelet-lymphocyte ratio for prognosis in advanced hypopharyngeal squamous cell carcinoma in individuals undergoing radical resection.
Chen H, Song S, Li A, Ma D, Lin C, Qian X, Gao X, Shen X
Acta Otolaryngol 2021 May;141(5):537-543. Epub 2021 Apr 19 doi: 10.1080/00016489.2021.1891456. PMID: 33872102
Utility of Esophagrams to Detect Prevertebral Invasion in Hypopharyngeal Squamous Cell Carcinoma.
Kaffenberger TM, Eichar B, Traylor KS, Kubik MW, Branstetter BF 4th
Laryngoscope 2021 Apr;131(4):800-805. Epub 2020 Aug 17 doi: 10.1002/lary.29011. PMID: 33270244
Treatment patterns and survival outcomes of advanced hypopharyngeal squamous cell carcinoma.
Tsai YT, Chen WC, Chien CY, Hsu CM, Lee YC, Tsai MS, Lin MH, Lai CH, Chang KP
World J Surg Oncol 2020 May 1;18(1):82. doi: 10.1186/s12957-020-01866-z. PMID: 32357934Free PMC Article
Definitive Chemoradiation in Locally Advanced Squamous Cell Carcinoma of the Hypopharynx: Long-term Outcomes and Toxicity.
Juloori A, Koyfman SA, Geiger JL, Joshi NP, Woody NM, Burkey BB, Scharpf J, Lamarre EL, Prendes B, Adelstein DJ, Greskovich JF, Keller L
Anticancer Res 2018 Jun;38(6):3543-3549. doi: 10.21873/anticanres.12626. PMID: 29848708

Clinical prediction guides

Nomograms predicting prognosis for locally advanced hypopharyngeal squamous cell carcinoma.
Yang H, Zeng M, Cao S, Jin L
Eur Arch Otorhinolaryngol 2022 Jun;279(6):3041-3052. Epub 2021 Oct 14 doi: 10.1007/s00405-021-07109-5. PMID: 34648051
Presurgical platelet-lymphocyte ratio for prognosis in advanced hypopharyngeal squamous cell carcinoma in individuals undergoing radical resection.
Chen H, Song S, Li A, Ma D, Lin C, Qian X, Gao X, Shen X
Acta Otolaryngol 2021 May;141(5):537-543. Epub 2021 Apr 19 doi: 10.1080/00016489.2021.1891456. PMID: 33872102
Utility of Esophagrams to Detect Prevertebral Invasion in Hypopharyngeal Squamous Cell Carcinoma.
Kaffenberger TM, Eichar B, Traylor KS, Kubik MW, Branstetter BF 4th
Laryngoscope 2021 Apr;131(4):800-805. Epub 2020 Aug 17 doi: 10.1002/lary.29011. PMID: 33270244
Prognostic values of preoperative platelet-to-lymphocyte ratio and platelet-related indices in advanced hypopharyngeal squamous cell carcinoma.
Lau HC, Hsueh CY, Chen Q, Tao L, Zhou L, Deng W, Zhang M
Clin Otolaryngol 2020 Mar;45(2):221-230. Epub 2020 Jan 3 doi: 10.1111/coa.13497. PMID: 31850682
Fibrinogen and Neutrophil-to-lymphocyte Ratio Predicts Survival in Patients with Advanced Hypopharyngeal Squamous Cell Carcinoma.
Kuwahara T, Takahashi H, Sano D, Matsuoka M, Hyakusoku H, Hatano T, Hiiragi Y, Oridate N
Anticancer Res 2018 Sep;38(9):5321-5330. doi: 10.21873/anticanres.12859. PMID: 30194184

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