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Steroid-Refractory Pneumonitis

MedGen UID:
1655674
•Concept ID:
C4744972
•
Disease or Syndrome

Definition

Pneumonitis that does not respond to corticosteroid therapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSteroid-Refractory Pneumonitis

Professional guidelines

PubMed

Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice recommendations for the management of immune-related adverse events: pulmonary toxicity.
Shannon VR, Anderson R, Blidner A, Choi J, Cooksley T, Dougan M, Glezerman I, Ginex P, Girotra M, Gupta D, Johnson DB, Suarez-Almazor ME, Rapoport BL
Support Care Cancer 2020 Dec;28(12):6145-6157. Epub 2020 Sep 3 doi: 10.1007/s00520-020-05708-2. PMID: 32880733Free PMC Article

Recent clinical studies

Etiology

Long-Term Clinical, Radiological, and Mortality Outcomes Following Pneumonitis in Nonsmall Cell Lung Cancer Patients Receiving Immune Checkpoint Inhibitors: A Retrospective Analysis.
Soto-Lanza F, Glick L, Chan C, Zhong L, Wilson N, Faiz S, Gandhi S, Naing A, Heymach JV, Shannon VR, Franco-Vega M, Liao Z, Lin SH, Palaskas NL, Wu J, Shroff GS, Altan M, Sheshadri A
Clin Lung Cancer 2024 Nov;25(7):624-633.e2. Epub 2024 Aug 3 doi: 10.1016/j.cllc.2024.07.017. PMID: 39183094
Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice recommendations for the management of immune-related adverse events: pulmonary toxicity.
Shannon VR, Anderson R, Blidner A, Choi J, Cooksley T, Dougan M, Glezerman I, Ginex P, Girotra M, Gupta D, Johnson DB, Suarez-Almazor ME, Rapoport BL
Support Care Cancer 2020 Dec;28(12):6145-6157. Epub 2020 Sep 3 doi: 10.1007/s00520-020-05708-2. PMID: 32880733Free PMC Article

Diagnosis

Prevalence and outcome of steroid-resistant/refractory pneumonitis induced by immune checkpoint inhibitors.
Camard M, Besse B, Cariou PL, Massayke S, Laparra A, Noel N, Michot JM, Ammari S, Pavec JL, Lambotte O
Respir Med Res 2022 Nov;82:100969. Epub 2022 Nov 9 doi: 10.1016/j.resmer.2022.100969. PMID: 36370683
Pulse corticosteroid therapy in the treatment of steroid-refractory immune checkpoint inhibitor-related pneumonitis: Case report and review.
Lai KC, Hsiao YH, Chen SC
Front Immunol 2022;13:994064. Epub 2022 Aug 31 doi: 10.3389/fimmu.2022.994064. PMID: 36119082Free PMC Article
Pneumonitis From Anti-PD-1/ PD-L1 Therapy.
Balaji A, Verde F, Suresh K, Naidoo J
Oncology (Williston Park) 2017 Oct 15;31(10):739-46, 754. PMID: 29083466

Therapy

Long-Term Clinical, Radiological, and Mortality Outcomes Following Pneumonitis in Nonsmall Cell Lung Cancer Patients Receiving Immune Checkpoint Inhibitors: A Retrospective Analysis.
Soto-Lanza F, Glick L, Chan C, Zhong L, Wilson N, Faiz S, Gandhi S, Naing A, Heymach JV, Shannon VR, Franco-Vega M, Liao Z, Lin SH, Palaskas NL, Wu J, Shroff GS, Altan M, Sheshadri A
Clin Lung Cancer 2024 Nov;25(7):624-633.e2. Epub 2024 Aug 3 doi: 10.1016/j.cllc.2024.07.017. PMID: 39183094
Prevalence and outcome of steroid-resistant/refractory pneumonitis induced by immune checkpoint inhibitors.
Camard M, Besse B, Cariou PL, Massayke S, Laparra A, Noel N, Michot JM, Ammari S, Pavec JL, Lambotte O
Respir Med Res 2022 Nov;82:100969. Epub 2022 Nov 9 doi: 10.1016/j.resmer.2022.100969. PMID: 36370683
Pulse corticosteroid therapy in the treatment of steroid-refractory immune checkpoint inhibitor-related pneumonitis: Case report and review.
Lai KC, Hsiao YH, Chen SC
Front Immunol 2022;13:994064. Epub 2022 Aug 31 doi: 10.3389/fimmu.2022.994064. PMID: 36119082Free PMC Article
Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice recommendations for the management of immune-related adverse events: pulmonary toxicity.
Shannon VR, Anderson R, Blidner A, Choi J, Cooksley T, Dougan M, Glezerman I, Ginex P, Girotra M, Gupta D, Johnson DB, Suarez-Almazor ME, Rapoport BL
Support Care Cancer 2020 Dec;28(12):6145-6157. Epub 2020 Sep 3 doi: 10.1007/s00520-020-05708-2. PMID: 32880733Free PMC Article
Pneumonitis From Anti-PD-1/ PD-L1 Therapy.
Balaji A, Verde F, Suresh K, Naidoo J
Oncology (Williston Park) 2017 Oct 15;31(10):739-46, 754. PMID: 29083466

Prognosis

Long-Term Clinical, Radiological, and Mortality Outcomes Following Pneumonitis in Nonsmall Cell Lung Cancer Patients Receiving Immune Checkpoint Inhibitors: A Retrospective Analysis.
Soto-Lanza F, Glick L, Chan C, Zhong L, Wilson N, Faiz S, Gandhi S, Naing A, Heymach JV, Shannon VR, Franco-Vega M, Liao Z, Lin SH, Palaskas NL, Wu J, Shroff GS, Altan M, Sheshadri A
Clin Lung Cancer 2024 Nov;25(7):624-633.e2. Epub 2024 Aug 3 doi: 10.1016/j.cllc.2024.07.017. PMID: 39183094

Clinical prediction guides

Prevalence and outcome of steroid-resistant/refractory pneumonitis induced by immune checkpoint inhibitors.
Camard M, Besse B, Cariou PL, Massayke S, Laparra A, Noel N, Michot JM, Ammari S, Pavec JL, Lambotte O
Respir Med Res 2022 Nov;82:100969. Epub 2022 Nov 9 doi: 10.1016/j.resmer.2022.100969. PMID: 36370683

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