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Metastatic Pancreatic Carcinoma

MedGen UID:
1656445
•Concept ID:
C0854775
•
Neoplastic Process

Definition

A carcinoma that arises from the pancreas and has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Influcence of localization of primary tumor on effectiveness of 5-fluorouracil/leucovorin combined with irinotecan and oxaliplatin (FOLFIRINOX) in patients with metastatic pancreatic adenocarcinoma: a retrospective study.
Lorgis V, Chauffert B, Gentil J, Ghiringhelli F
Anticancer Res 2012 Sep;32(9):4125-30. PMID: 22993372
Gemcitabine alone versus combination of gemcitabine and cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: a retrospective analysis of multicenter study.
Inal A, Kos FT, Algin E, Yildiz R, Dikiltas M, Unek IT, Colak D, Elkiran ET, Helvaci K, Geredeli C, Dane F, Balakan O, Kaplan MA, Durnali AG, Harputoglu H, Goksel G, Ozdemir N, Buyukberber S, Gumus M, Kucukoner M, Ozkan M, Uncu D, Benekli M, Isikdogan A
Neoplasma 2012;59(3):297-301. doi: 10.4149/neo_2012_038. PMID: 22329849
Advanced pancreatic carcinoma: current treatment and future challenges.
Stathis A, Moore MJ
Nat Rev Clin Oncol 2010 Mar;7(3):163-72. Epub 2010 Jan 26 doi: 10.1038/nrclinonc.2009.236. PMID: 20101258

Recent clinical studies

Etiology

Positron emission tomography and computed tomography with [(68)Ga]Ga-fibroblast activation protein inhibitors improves tumor detection and staging in patients with pancreatic cancer.
Pang Y, Zhao L, Shang Q, Meng T, Zhao L, Feng L, Wang S, Guo P, Wu X, Lin Q, Wu H, Huang W, Sun L, Chen H
Eur J Nucl Med Mol Imaging 2022 Mar;49(4):1322-1337. Epub 2021 Oct 15 doi: 10.1007/s00259-021-05576-w. PMID: 34651226
Association between neutropenia and survival to nab-paclitaxel and gemcitabine in patients with metastatic pancreatic cancer.
Roviello G, Ramello M, Catalano M, D'Angelo A, Conca R, Gasperoni S, Dreoni L, Petrioli R, Ianza A, Nobili S, Aieta M, Mini E
Sci Rep 2020 Nov 6;10(1):19281. doi: 10.1038/s41598-020-76465-9. PMID: 33159172Free PMC Article
A 10-year review of survival among patients with metastatic gastrointestinal cancers: a population-based study.
Abdel-Rahman O
Int J Colorectal Dis 2020 May;35(5):911-920. Epub 2020 Mar 17 doi: 10.1007/s00384-020-03568-0. PMID: 32185469
Metastatic Pancreatic Carcinoma and Experience with FOLFIRINOX - a Cross Sectional Analysis From a Developing Country.
Zahir MN, Jabbar AA
Asian Pac J Cancer Prev 2015;16(14):6001-6. doi: 10.7314/apjcp.2015.16.14.6001. PMID: 26320487
A Phase II study of gemcitabine and docetaxel in patients with metastatic pancreatic carcinoma.
Ryan DP, Kulke MH, Fuchs CS, Grossbard ML, Grossman SR, Morgan JA, Earle CC, Shivdasani R, Kim H, Mayer RJ, Clark JW
Cancer 2002 Jan 1;94(1):97-103. doi: 10.1002/cncr.10202. PMID: 11815964

Diagnosis

A comprehensive analysis of GATA3 expression in carcinomas of various origins with emphasis on lung carcinomas.
Bota EC, Koumoundourou D, Ravazoula P, Zolota V, Psachoulia C, Kardari M, Karampitsakos T, Tzouvelekis A, Tzelepi V, Sampsonas F
Monaldi Arch Chest Dis 2023 Aug 29;94(2) doi: 10.4081/monaldi.2023.2641. PMID: 37667882
A 10-year review of survival among patients with metastatic gastrointestinal cancers: a population-based study.
Abdel-Rahman O
Int J Colorectal Dis 2020 May;35(5):911-920. Epub 2020 Mar 17 doi: 10.1007/s00384-020-03568-0. PMID: 32185469
An unusual presentation of multiple myeloma.
Schembri EL, Mifsud S, Gauci J, Mizzi A, Fsadni P
BMJ Case Rep 2018 Nov 28;11(1) doi: 10.1136/bcr-2018-226412. PMID: 30567104Free PMC Article
Metastatic Pancreatic Carcinoma and Experience with FOLFIRINOX - a Cross Sectional Analysis From a Developing Country.
Zahir MN, Jabbar AA
Asian Pac J Cancer Prev 2015;16(14):6001-6. doi: 10.7314/apjcp.2015.16.14.6001. PMID: 26320487
The pathology and genetics of metastatic pancreatic cancer.
Yachida S, Iacobuzio-Donahue CA
Arch Pathol Lab Med 2009 Mar;133(3):413-22. doi: 10.5858/133.3.413. PMID: 19260747

Therapy

Association between neutropenia and survival to nab-paclitaxel and gemcitabine in patients with metastatic pancreatic cancer.
Roviello G, Ramello M, Catalano M, D'Angelo A, Conca R, Gasperoni S, Dreoni L, Petrioli R, Ianza A, Nobili S, Aieta M, Mini E
Sci Rep 2020 Nov 6;10(1):19281. doi: 10.1038/s41598-020-76465-9. PMID: 33159172Free PMC Article
An unusual presentation of multiple myeloma.
Schembri EL, Mifsud S, Gauci J, Mizzi A, Fsadni P
BMJ Case Rep 2018 Nov 28;11(1) doi: 10.1136/bcr-2018-226412. PMID: 30567104Free PMC Article
Metastatic Pancreatic Carcinoma and Experience with FOLFIRINOX - a Cross Sectional Analysis From a Developing Country.
Zahir MN, Jabbar AA
Asian Pac J Cancer Prev 2015;16(14):6001-6. doi: 10.7314/apjcp.2015.16.14.6001. PMID: 26320487
Metastasized pancreatic carcinoma with neoadjuvant FOLFIRINOX therapy and R0 resection.
Schneitler S, Kröpil P, Riemer J, Antoch G, Knoefel WT, Häussinger D, Graf D
World J Gastroenterol 2015 May 28;21(20):6384-90. doi: 10.3748/wjg.v21.i20.6384. PMID: 26034375Free PMC Article
Advanced pancreatic carcinoma: current treatment and future challenges.
Stathis A, Moore MJ
Nat Rev Clin Oncol 2010 Mar;7(3):163-72. Epub 2010 Jan 26 doi: 10.1038/nrclinonc.2009.236. PMID: 20101258

Prognosis

Association between neutropenia and survival to nab-paclitaxel and gemcitabine in patients with metastatic pancreatic cancer.
Roviello G, Ramello M, Catalano M, D'Angelo A, Conca R, Gasperoni S, Dreoni L, Petrioli R, Ianza A, Nobili S, Aieta M, Mini E
Sci Rep 2020 Nov 6;10(1):19281. doi: 10.1038/s41598-020-76465-9. PMID: 33159172Free PMC Article
A 10-year review of survival among patients with metastatic gastrointestinal cancers: a population-based study.
Abdel-Rahman O
Int J Colorectal Dis 2020 May;35(5):911-920. Epub 2020 Mar 17 doi: 10.1007/s00384-020-03568-0. PMID: 32185469
Metastatic Pancreatic Carcinoma and Experience with FOLFIRINOX - a Cross Sectional Analysis From a Developing Country.
Zahir MN, Jabbar AA
Asian Pac J Cancer Prev 2015;16(14):6001-6. doi: 10.7314/apjcp.2015.16.14.6001. PMID: 26320487
Metastasized pancreatic carcinoma with neoadjuvant FOLFIRINOX therapy and R0 resection.
Schneitler S, Kröpil P, Riemer J, Antoch G, Knoefel WT, Häussinger D, Graf D
World J Gastroenterol 2015 May 28;21(20):6384-90. doi: 10.3748/wjg.v21.i20.6384. PMID: 26034375Free PMC Article
Advanced pancreatic carcinoma: current treatment and future challenges.
Stathis A, Moore MJ
Nat Rev Clin Oncol 2010 Mar;7(3):163-72. Epub 2010 Jan 26 doi: 10.1038/nrclinonc.2009.236. PMID: 20101258

Clinical prediction guides

Positron emission tomography and computed tomography with [(68)Ga]Ga-fibroblast activation protein inhibitors improves tumor detection and staging in patients with pancreatic cancer.
Pang Y, Zhao L, Shang Q, Meng T, Zhao L, Feng L, Wang S, Guo P, Wu X, Lin Q, Wu H, Huang W, Sun L, Chen H
Eur J Nucl Med Mol Imaging 2022 Mar;49(4):1322-1337. Epub 2021 Oct 15 doi: 10.1007/s00259-021-05576-w. PMID: 34651226
Anti-EGFR chimeric antigen receptor-modified T cells in metastatic pancreatic carcinoma: A phase I clinical trial.
Liu Y, Guo Y, Wu Z, Feng K, Tong C, Wang Y, Dai H, Shi F, Yang Q, Han W
Cytotherapy 2020 Oct;22(10):573-580. Epub 2020 Jun 9 doi: 10.1016/j.jcyt.2020.04.088. PMID: 32527643
A 10-year review of survival among patients with metastatic gastrointestinal cancers: a population-based study.
Abdel-Rahman O
Int J Colorectal Dis 2020 May;35(5):911-920. Epub 2020 Mar 17 doi: 10.1007/s00384-020-03568-0. PMID: 32185469
Patterns of EphA2 protein expression in primary and metastatic pancreatic carcinoma and correlation with genetic status.
Mudali SV, Fu B, Lakkur SS, Luo M, Embuscado EE, Iacobuzio-Donahue CA
Clin Exp Metastasis 2006;23(7-8):357-65. Epub 2006 Dec 5 doi: 10.1007/s10585-006-9045-7. PMID: 17146615Free PMC Article
Combining capecitabine and gemcitabine in patients with advanced pancreatic carcinoma: a phase I/II trial.
Hess V, Salzberg M, Borner M, Morant R, Roth AD, Ludwig C, Herrmann R
J Clin Oncol 2003 Jan 1;21(1):66-8. doi: 10.1200/JCO.2003.04.029. PMID: 12506172

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