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Carcinoma of pancreas

MedGen UID:
65917
•Concept ID:
C0235974
•
Neoplastic Process
Synonyms: Exocrine pancreatic carcinoma; PANCREATIC ACINAR CARCINOMA; Pancreatic cancer, somatic; PANCREATIC CARCINOMA; Pancreatic carcinoma, somatic
SNOMED CT: Carcinoma of pancreas (372142002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Genes (locations): ACVR1B (12q13.13); KRAS (12p12.1); SMAD4 (18q21.2); STK11 (19p13.3); TP53 (17p13.1)
 
Monarch Initiative: MONDO:0005192
OMIM®: 260350
Orphanet: ORPHA217074

Definition

A carcinoma arising from the exocrine pancreas. The overwhelming majority of pancreatic carcinomas are adenocarcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
Follow this link to review classifications for Carcinoma of pancreas in Orphanet.

Professional guidelines

PubMed

Efficacy of carcinogenic embryonic antigen in differential diagnosis of diseases of pancreas and liver--a comparative study in a tertiary care hospital of Western Nepal.
Mittal A, Farooqui SM, Pyrtuh S, Poudel B, Sathian B, Yadav SK
Asian Pac J Cancer Prev 2012;13(1):275-7. doi: 10.7314/apjcp.2012.13.1.275. PMID: 22502684
Evaluation & management of clinically labeled carcinoma head of the pancreas--a prospective study of 60 patients.
Ali M, Zafar SM, Das BC, Rabbi H, Fazal NM, Roy S, Imam NA, Islam MM
Bangladesh Med Res Counc Bull 2003 Apr;29(1):29-37. PMID: 14674618
Influence of multimodality therapy on the management of pancreas carcinoma.
Jessup JM, Posner M, Huberman M
Semin Surg Oncol 1993 Jan-Feb;9(1):27-32. doi: 10.1002/ssu.2980090106. PMID: 8356381

Curated

Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

Recent clinical studies

Etiology

A case of primary squamous cell carcinoma of the pancreas with gastric invasion, and a review of the literature.
Chen J, Wang C, Ma R, Wan S, Wang B
Ann Ital Chir 2023 Mar 6;12 PMID: 36924068
Malignancies in spondyloarthritis with and without concomitant psoriasis, and the effect of disease modifying anti-rheumatic drugs.
Chung HY, Chan SCW, Chui ETF, Yau T, Lau CS
Clin Exp Rheumatol 2022 May;40(5):913-920. Epub 2021 Jul 24 doi: 10.55563/clinexprheumatol/o3rgv1. PMID: 34369368
Efficacy of carcinogenic embryonic antigen in differential diagnosis of diseases of pancreas and liver--a comparative study in a tertiary care hospital of Western Nepal.
Mittal A, Farooqui SM, Pyrtuh S, Poudel B, Sathian B, Yadav SK
Asian Pac J Cancer Prev 2012;13(1):275-7. doi: 10.7314/apjcp.2012.13.1.275. PMID: 22502684
Evidence of decreased risk of cancer in individuals with fragile X.
Schultz-Pedersen S, Hasle H, Olsen JH, Friedrich U
Am J Med Genet 2001 Oct 15;103(3):226-30. PMID: 11745995
Multifactorial analysis of prognostic factors in emergency abdominal surgery in patients above 80 years. Analysis of 154 consecutive cases.
Reiss R, Deutsch AA, Nudelman I, Gutman H
Int Surg 1989 Apr-Jun;74(2):93-6. PMID: 2753629

Diagnosis

Mixed neuroendocrine non-neuroendocrine neoplasm: a case report and review.
Hiroi S, Yamamoto R, Hamaoka M, Hoshino M, Sasaki T, Matsugu Y, Nishisaka T, Nakahara H, Itamoto T
Clin J Gastroenterol 2022 Feb;15(1):244-255. Epub 2021 Nov 18 doi: 10.1007/s12328-021-01552-x. PMID: 34796444
Malignancies in spondyloarthritis with and without concomitant psoriasis, and the effect of disease modifying anti-rheumatic drugs.
Chung HY, Chan SCW, Chui ETF, Yau T, Lau CS
Clin Exp Rheumatol 2022 May;40(5):913-920. Epub 2021 Jul 24 doi: 10.55563/clinexprheumatol/o3rgv1. PMID: 34369368
4H12, a Murine Monoclonal Antibody Directed against Myosin Heavy Chain-9 Expressed on Acinar Cell Carcinoma of Pancreas with Potential Therapeutic Application.
Balouchi-Anaraki S, Ahmadvand S, Safaei A, Ghaderi A
Iran Biomed J 2021 Sep 1;25(5):310-22. doi: 10.52547/ibj.25.5.310. [Epub ahead of print] PMID: 34425650Free PMC Article
Cytological, histological, and molecular characteristics of pure invasive micropapillary carcinoma of pancreas: A case report.
Lee SJ, Bae HI, Yoon G, Cho CM, Kwon HJ, Park J, Cho SH, Seo AN
Medicine (Baltimore) 2020 Jun 12;99(24):e20668. doi: 10.1097/MD.0000000000020668. PMID: 32541511Free PMC Article
Undifferentiated Carcinoma of the Pancreas - a Case Report.
Kašperová B, Jurišová S, Macúch J, Bumberová M, Janega P, Dolinský J, Mego M
Klin Onkol 2018 Winter;31(6):453-456. doi: 10.14735/amko2018453. PMID: 31035768

Therapy

Malignancies in spondyloarthritis with and without concomitant psoriasis, and the effect of disease modifying anti-rheumatic drugs.
Chung HY, Chan SCW, Chui ETF, Yau T, Lau CS
Clin Exp Rheumatol 2022 May;40(5):913-920. Epub 2021 Jul 24 doi: 10.55563/clinexprheumatol/o3rgv1. PMID: 34369368
4H12, a Murine Monoclonal Antibody Directed against Myosin Heavy Chain-9 Expressed on Acinar Cell Carcinoma of Pancreas with Potential Therapeutic Application.
Balouchi-Anaraki S, Ahmadvand S, Safaei A, Ghaderi A
Iran Biomed J 2021 Sep 1;25(5):310-22. doi: 10.52547/ibj.25.5.310. [Epub ahead of print] PMID: 34425650Free PMC Article
Undifferentiated Carcinoma of the Pancreas - a Case Report.
Kašperová B, Jurišová S, Macúch J, Bumberová M, Janega P, Dolinský J, Mego M
Klin Onkol 2018 Winter;31(6):453-456. doi: 10.14735/amko2018453. PMID: 31035768
The current status of preoperative biliary drainage for patients who receive pancreaticoduodenectomy for periampullary carcinoma: a comprehensive review.
Lai EC, Lau SH, Lau WY
Surgeon 2014 Oct;12(5):290-6. Epub 2014 Mar 17 doi: 10.1016/j.surge.2014.02.004. PMID: 24650759
A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer.
Zhou Q, Gustafson D, Nallapareddy S, Diab S, Leong S, Lewis K, Gore L, Messersmith WA, Treston AM, Eckhardt SG, Sidor C, Camidge DR
Invest New Drugs 2011 Apr;29(2):340-6. Epub 2010 Jan 19 doi: 10.1007/s10637-009-9383-9. PMID: 20084425Free PMC Article

Prognosis

4H12, a Murine Monoclonal Antibody Directed against Myosin Heavy Chain-9 Expressed on Acinar Cell Carcinoma of Pancreas with Potential Therapeutic Application.
Balouchi-Anaraki S, Ahmadvand S, Safaei A, Ghaderi A
Iran Biomed J 2021 Sep 1;25(5):310-22. doi: 10.52547/ibj.25.5.310. [Epub ahead of print] PMID: 34425650Free PMC Article
Undifferentiated Carcinoma of the Pancreas - a Case Report.
Kašperová B, Jurišová S, Macúch J, Bumberová M, Janega P, Dolinský J, Mego M
Klin Onkol 2018 Winter;31(6):453-456. doi: 10.14735/amko2018453. PMID: 31035768
Efficacy of carcinogenic embryonic antigen in differential diagnosis of diseases of pancreas and liver--a comparative study in a tertiary care hospital of Western Nepal.
Mittal A, Farooqui SM, Pyrtuh S, Poudel B, Sathian B, Yadav SK
Asian Pac J Cancer Prev 2012;13(1):275-7. doi: 10.7314/apjcp.2012.13.1.275. PMID: 22502684
Evidence of decreased risk of cancer in individuals with fragile X.
Schultz-Pedersen S, Hasle H, Olsen JH, Friedrich U
Am J Med Genet 2001 Oct 15;103(3):226-30. PMID: 11745995
Pancreatic carcinoma.
Ajao OG, Abioye AA
J Natl Med Assoc 1980 Jun;72(6):589-90. PMID: 7392077Free PMC Article

Clinical prediction guides

Malignancies in spondyloarthritis with and without concomitant psoriasis, and the effect of disease modifying anti-rheumatic drugs.
Chung HY, Chan SCW, Chui ETF, Yau T, Lau CS
Clin Exp Rheumatol 2022 May;40(5):913-920. Epub 2021 Jul 24 doi: 10.55563/clinexprheumatol/o3rgv1. PMID: 34369368
Undifferentiated Carcinoma of the Pancreas - a Case Report.
Kašperová B, Jurišová S, Macúch J, Bumberová M, Janega P, Dolinský J, Mego M
Klin Onkol 2018 Winter;31(6):453-456. doi: 10.14735/amko2018453. PMID: 31035768
A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer.
Zhou Q, Gustafson D, Nallapareddy S, Diab S, Leong S, Lewis K, Gore L, Messersmith WA, Treston AM, Eckhardt SG, Sidor C, Camidge DR
Invest New Drugs 2011 Apr;29(2):340-6. Epub 2010 Jan 19 doi: 10.1007/s10637-009-9383-9. PMID: 20084425Free PMC Article
Relative frequency and morphology of cancers in carriers of germline TP53 mutations.
Birch JM, Alston RD, McNally RJ, Evans DG, Kelsey AM, Harris M, Eden OB, Varley JM
Oncogene 2001 Aug 2;20(34):4621-8. doi: 10.1038/sj.onc.1204621. PMID: 11498785
Multifactorial analysis of prognostic factors in emergency abdominal surgery in patients above 80 years. Analysis of 154 consecutive cases.
Reiss R, Deutsch AA, Nudelman I, Gutman H
Int Surg 1989 Apr-Jun;74(2):93-6. PMID: 2753629

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    Curated

    • AHRQ, 2013
      Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

    Consumer resources

    Reviews

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      Related information in NCBI Gene
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      Related information in GTR
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      Clinical tests in GTR
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